Gum ghatti based hydrogel: Microwave synthesis, characterization, 5-Fluorouracil encapsulation and ‘in vitro’ drug release evaluation

Pal, Pinki; Singh, Srikant Kumar; Mishra, Sumit; Pandey, Jay Prakash; Sen, Gautam

doi:10.1016/j.carbpol.2019.114979

Cited by 51 publications

(10 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many new technologies have been used to prepare hydrogel particles of different sizes, including microfluidics methods, emulsion, and nano molding techniques, where the size of the hydrogel particles can be controlled by controlling the gelation conditions or processing parameters [ 92 ]. The mesh size [ 93 ] and the mechanism of cross-linking of hydrogels determine how the drug diffuses through the hydrogel because they control the steric interactions between the drugs and the polymer network, which can be controlled by the concentration of polymer and crosslinker as well as external stimuli such as temperature and pH [ 91 , 94 ]. For example, semi-IPN [ 95 ] can more effectively maintain a fast dynamic response rate to pH or temperature with its unrestricted interpenetrating elastic network, and the main advantages of IPN [ 95 ] is that they can produce relatively dense hydrogel matrices with higher mechanical properties, more efficient drug loading, and controlled physical properties.…”

Section: Design Of Hydrogels For Bone Tissue Engineeringmentioning

confidence: 99%

Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

et al. 2020

View full text Add to dashboard Cite

Severe bone damage from diseases, including extensive trauma, fractures, and bone tumors, cannot self-heal, while traditional surgical treatment may bring side effects such as infection, inflammation, and pain. As a new biomaterial with controllable mechanical properties and biocompatibility, hydrogel is widely used in bone tissue engineering (BTE) as a scaffold for growth factor transport and cell adhesion. In order to make hydrogel more suitable for the local treatment of bone diseases, hydrogel preparation methods should be combined with synthetic materials with excellent properties and advanced technologies in different fields to better control drug release in time and orientation. It is necessary to establish a complete method to evaluate the hydrogel’s properties and biocompatibility with the human body. Moreover, establishment of standard animal models of bone defects helps in studying the therapeutic effect of hydrogels on bone repair, as well as to evaluate the safety and suitability of hydrogels. Thus, this review aims to systematically summarize current studies of hydrogels in BTE, including the mechanisms for promoting bone synthesis, design, and preparation; characterization and evaluation methods; as well as to explore future applications of hydrogels in BTE.

show abstract

Section: Design Of Hydrogels For Bone Tissue Engineeringmentioning

confidence: 99%

Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…SEM was used to examine the characteristics of GG, -o-MWCNTs GG, Gum ghatti-cl-poly(acrylic acid) and Gum ghatti-cl-poly(acrylic acid)/-o-MWCNT hydrogel. The granular shape of GG was visible in the SEM image, indicating that the biopolymer is amorphous 53,54 (Figure 3a). Because of the defective patches formed by oxidation, the surface of the oxidized MWCNTs appears rough (Figure 3b).…”

Section: Sem Study (Morphological Investigation)mentioning

confidence: 99%

Oxidized multiwalled carbon nanotube reinforced rheological examination on Gum ghatti‐cl‐poly(acrylic acid) hydrogels

Kamaliya

Dave

Macwan³

2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

The intention of the present study was to synthesize Gum ghatti-cl-poly(acrylic acid)/-o-MWCNT hydrogel by free radical copolymerization method where the role of various ingredients are as: Gum ghatti as biopolymer (GG), acrylic acid (AA) as a probe for synthetic monomer, ammonium persulfate as initiator and methylene bis-acrylamide (MBA) as a crosslinker. The oxidized multiwalled nanocarbon tubes (-o-MWCNT) with variable amounts (0-50 mg) were used as fillers. The as-prepared hydrogels were characterized by X-ray diffraction, scanning electron microscope and Fourier transform infrared spectroscopy.The rheological investigation of hydrogels revealed that the storage modulus (G 0 ) was always higher than the loss modulus (G 00 ) in the linear viscoelastic region over the entire frequency range. The persistent covalence crosslinking is responsible for the solid-like behavior and elastic nature (G 0 > G 00 ). Hydrogels containing Gum ghatti-cl-poly(acrylic acid)/-o-MWCNT increased with strain. The nonlinear oscillatory shear increases by the addition -o-MWCNT.The features shown highlight the potential of Gum ghatti-cl-poly(acrylic acid)/-o-MWCNT hydrogels for agricultural, medicinal, and pharmaceutical applications.

show abstract

“…Temperature was maintained at 37 ± 0.5°C with paddle speed of 50 rpm. At predetermined time intervals samples were removed and analyzed for Capecitabine release using UV visible spectrophotometer at pre‐scanned λ max (300 nm) 23,24 …”

Section: Characterizationmentioning

confidence: 99%

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Rehman

Sarfraz

Mahmood

et al. 2021

Polymers for Advanced Techs

View full text Add to dashboard Cite

This project was designed to develop pH responsive smart chitosan/agarose‐g‐poly (methacrylate) hydrogels using free radical polymerization for targeted delivery of Capecitabine (a prodrug of 5‐fluorouracil) for the treatment of colorectal cancer. Developed hydrogels were evaluated for drug loading efficiency, thermal stability, compatibility of components, morphology, swelling behavior, release kinetics and acute oral toxicity studies in rabbits. Moreover, pharmacokinetic parameters were also measured in healthy rabbits. Structural entanglement was confirmed via FTIR providing evidence of hydrogel formation. Loading of Capecitabine was in range from 60.35% to 62.57%. Hydrogels showed pH‐responsive behavior by providing maximum swelling of 93.84% at pH 7.4 identical to colon. Release of Capecitabine from hydrogels was in controlled pattern over a period of 36 h. Toxicity studies revealed no signs of ocular, dermal and oral toxicity providing safety evidence of hydrogels. In addition, pharmacokinetic evaluations of Capecitabine loaded hydrogels showed significant increase in plasma half‐life of 17 h and AUC of 57.65 μg.h/ml in comparison to pure Capecitabine solution. Therefore, these results strongly suggest that newly formed hydrogels are biocompatible, capable of providing sustained release at specific pH and can be employed as a cargo for colorectal delivery.

show abstract

Gum ghatti based hydrogel: Microwave synthesis, characterization, 5-Fluorouracil encapsulation and ‘in vitro’ drug release evaluation

Cited by 51 publications

References 35 publications

Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

Oxidized multiwalled carbon nanotube reinforced rheological examination on Gum ghatti‐cl‐poly(acrylic acid) hydrogels

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Contact Info

Product

Resources

About