Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation

Kokkiripati, Praveen K.; Bhakshu, Lepakshi Md.; Swathi, M; Padmasree, Kollipara; Row, Anupama T.; Raghavendra, Agepati S.; Tetali, Sarada D.

doi:10.1016/j.jep.2011.07.004

Cited by 44 publications

(17 citation statements)

References 23 publications

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“…This finding was similar to the finding of Kokkiripati et al . (), who reported that EBS and ABS extracts of B . serrata contained 9% (w/w) and 7.8% (w/w) AKBA, respectively.…”

Section: Discussionmentioning

confidence: 98%

“…B . serrata resin has potent antioxidant and immunomodulatory properties as proved by earlier published evidences (Ammon, ; Kokkiripati et al ., ; Hartmann et al ., ; Umar et al ., ). In an experimental model of acute ulcerative colitis, treatment with the extract of B .…”

Section: Discussionmentioning

confidence: 99%

“…Also, it has been shown that B . serrata resin possesses strong antioxidant and immunomodulatory properties (Ammon, ; Kokkiripati et al ., ).…”

Section: Introductionmentioning

confidence: 97%

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Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

Forouzanfar

Hosseinzadeh

Ebrahimzadeh‐Bideskan

et al. 2016

Phytotherapy Research

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Oxidative stress and cell apoptosis play major roles in neuronal injury after ischemia-reperfusion (I-R) injury. Boswellia serrata is a medicinal plant with antioxidant properties. Acetyl-11-keto-β-boswellic acid (AKBA) is an active triterpenoid compound from B. serrate. In the current study, the neuroprotective effects of aqueous and ethanolic extracts of B. serrata (named ABS and EBS, respectively) and AKBA were investigated against middle cerebral artery occlusion-induced cerebral I-R injury in rats. ABS and EBS with doses of 125, 250 and 500 and AKBA with a dose of 50 mg/kg were administered (intraperitoneally) just after middle cerebral artery occlusion induction for 30 min and reperfusion for 24 h. HPLC analysis suggested that ABS and EBS had AKBA of 8.8% and 9.5% (w/w), respectively. B. serrata and AKBA significantly improved neurological deficit and reduced brain infarction, neuronal cell loss and apoptosis and also attenuated lipid peroxidation while increasing glutathione content and superoxide dismutase activity in the cerebral cortex following a stroke. Apoptosis suppression was found to be mediated through regulating caspase-3 and bax/bcl-2 expressions. In conclusion, our results demonstrated that B. serrata and AKBA attenuate oxidative damage and inhibit cell apoptosis, subsequently protecting cerebral I-R injury in rats. Copyright © 2016 John Wiley & Sons, Ltd.

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“…This finding was similar to the finding of Kokkiripati et al . (), who reported that EBS and ABS extracts of B . serrata contained 9% (w/w) and 7.8% (w/w) AKBA, respectively.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

Forouzanfar

Hosseinzadeh

Ebrahimzadeh‐Bideskan

et al. 2016

Phytotherapy Research

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“…It shows antioxidative, antithrombotic, hemostatic, anti-inflammatory properties and cardiovascular health effects. [59] Gum resin of B. serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation. Addition of dietary fibers decreases serum cholesterol, triglycerides, increasing the high density lipoprotein cholesterol level, and the management of glycemic indices and obesity.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Untitled

Upadhyay

2017

IJGP

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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also used in food, pharmaceutical, paper textile, and other industries. The present review also explains various biological activities such as antidiarrheic, antitumor, anti-inflammatory, anti-arthritic, antiparasitic, gastrourinary, antitumor, antiparasitic, antioxidant, chemopreventive, and gastroprotective activity of plant gums. These reduce stomach inflammation, system cleansing or to settle the intestines. Other uses for mesquite gum include treatment for lice, sore throat, cough, laryngitis, fever reduction, painful gums, and hemorrhoids and it can be used as a purgative. Gum arabic is a water-soluble dietary fiber rich in Ca , and decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na + . Gums are used as adhesives, crystallization inhibitors, emulsifying agents, emulsion stabilizers, encapsulating agents, film formers, foam stabilizers, suspending agents, suspension stabilizers, or syneresis inhibitors and impart other specific properties. The gum is also used to a limited extent in polishes, contact insecticides and pesticides, photographic emulsions, and pharmaceuticals. This article suggests wider use of plant gums in generation of drug delivery system for cancer and brain tumor therapy. There is no doubt that chemical constituents of plant gums can be largely used for making therapeutic drugs because of their broadspectrum biological effectiveness.

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“…It has also been officially listed in the Chinese Pharmacopoeia that composes of 56 Chinese herbal formulas (Pharmacopoeia, 2010), due to significant effectiveness of its therapeutic effects. In recent years, it has been receiving increased attention for its extensive and beneficial bioactivities, such as anti-inflammatory, antinociceptive (Mothana, 2011), anti-tumor (Eichhorn et al, 2011, and antibacterial (Hasson et al, 2011) activities, as well as inhibition of platelet aggregation (Kokkiripati et al, 2011). It was also reported that European Medicines Agency (EMA) Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/jep granted the extracts of resin of Boswellia serrata gum as an 'orphan drug' for the treatment of peritumoral brain edema.…”

Section: Introductionmentioning

confidence: 99%

Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products

Pan

Liang

Niu

et al. 2015

Journal of Ethnopharmacology

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Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation

Cited by 44 publications

References 23 publications

Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

Aqueous and Ethanolic Extracts of Boswellia serrata Protect Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

Untitled

Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products

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