Gundelia tournefortii inhibits hepatocellular carcinoma progression by lowering gene expression of the cell cycle and hepatocyte proliferation in immunodeficient mice

Amer, Johnny; Ahmad, Saboor; Jaradat, Nidal; Abdallah, Samer; Aburas, Hanood; Hattab, Suhaib; Ghanim, Mustafa; Alqub, Malik

doi:10.1016/j.biopha.2022.113885

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…Another study on G. tournefortii anticancer potential based on hepatocellular carcinoma (HCC‐Hep3B injected into a mouse) animal model showed that aqueous extract inhibited the 3D multicellular tumor spheroids HCC formation as an anticancer (Table 3). [136] G. tournefortii suppressed hepatocellular carcinoma progression by reducing the expression of genes related to the cell cycle and hepatocyte proliferation [137] …”

Section: Resultsmentioning

confidence: 99%

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

Mehrzadeh,

Ziayeezadeh,

Pasdaran

et al. 2024

Chemistry & Biodiversity

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A comprehensive literature search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, the National Library of Medicine (NLM) catalog, and Google Scholar from January 1980 up until October 2023 on plants in the Gundelia genus. Gundelia L. (Asteraceae) has been treated as a monospecific genus with G. tournefortii L. (1753: 814) in most recent floras with wide variation in corolla color, but nowadays, the genus consists of 17 species. The unripe inflorescences of these species, especially Gundelia tournefortii L., are consumed in many ways. 'Akkoub' or 'akko' in Arabic, “Kangar” in Persian, and “Silifa” in Greek are the common names of G. tournefortii L., also known as tumble thistle in English. They have been used in traditional medicine to treat bronchitis, kidney stones, diarrhea, stomach pain, inflammation, liver and blood diseases, bacterial and fungal infections, and mumps. Based on recent studies, their extracts have exhibited hepatoprotective, hypolipidemic, antioxidant, anti‐inflammatory, and antimicrobial effects. Moreover, a variety of phytochemicals, including terpenoids, sterols, and fatty acids, as well as vitamins and minerals, have been identified in this genus. This study reviewed the ethnobotany, phytochemicals, and biological activities of the plants in the Gundelia genus as functional foods and herbal remedies.

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Section: Resultsmentioning

confidence: 99%

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

Mehrzadeh,

Ziayeezadeh,

Pasdaran

et al. 2024

Chemistry & Biodiversity

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“…Images of the formed spheroids/clusters were captured at 0 h and 24 h using an inverted microscope with a final magnification of 100×. The photographs of the spheroids were assessed and quantified using ImageJ software [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Anticancer Activity of Thiophene Carboxamide Derivatives as CA-4 Biomimetics: Synthesis, Biological Potency, 3D Spheroid Model, and Molecular Dynamics Simulation

et al. 2022

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The present study aimed to synthesize thiophene carboxamide derivatives, which are considered biomimetics of the anticancer medication Combretastatin A-4 (CA-4), and compare the similarity in the polar surface area (PSA) between the novel series and CA-4. Our results showed that the PSA of the most synthesized structures was biomimetic to CA-4, and similar chemical and biological properties were observed against Hep3B cancer cell line. Among the synthesized series 2b and 2e compounds were the most active molecules on Hep3B (IC50 = 5.46 and 12.58 µM, respectively). The 3D results revealed that both 2b and 2e structures confuse the surface of Hep3B cancer cell lines’ spheroid formation and force these cells to aggregate into a globular-shaped spheroid. The 2b and 2e showed a comparable interaction pattern to that observed for CA-4 and colchicine within the tubulin-colchicine-binding pocket. The thiophene ring, due to holding a high aromaticity character, participated critically in that observed interaction profile and showed additional advanced interactions over CA-4. The 2b and 2e tubulin complexes showed optimal dynamics trajectories within a time scale of 100 ns at 300 K temperature, which asserts their high stability and compactness. Together, these findings revealed the biomimetic role of 2b and 2e compounds in CA-4 in preventing cancer progression.

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“…[45] Aqueous extract of flowering buds was prepared and used to treat inflammation caused by implanted hepatocarcinoma cells in mice (reduction of F4/80 count). [46] Majorana syriaca Aerial parts EO was prepared and analyzed with GC-MS for chemical composition. Major compounds are shown in Fig.…”

Section: Table 1 Published Anti-inflammatory Activities Of the D-p In...mentioning

confidence: 99%

Top Edible Wild Plants of Eastern Mediterranean Region Part II: Anti-inflammatory Activity

Azab

2023

EJMP

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In the first part of this series of review articles, we presented the anticancer activities of the most important wild edible plants of eastern Mediterranean region, which we named as the “Deca-plants” (D-P). In this review article, we will present the anti-inflammatory activities of these very important plants. After a brief introduction, anti-inflammatory activities of the D-P will be introduced in both traditional medicine of the peoples of this region, and in published scientific literature. Methods of use will be presented in the first part, and methods of testing and results, for modern research. In both cases, some of the D-P have notable anti-inflammatory activities. In the extensive discussion section of this article, a major focus will be presented for anti-inflammatory activities of natural products contained in these plants, and some comparisons will be made with other plants. At this point, it is worth mentioning that the D-P have notably different number of anti-inflammatory activity reports, where on the top of them Foeniculum vulgare can be found. Contrary to that and to the best of our knowledge, Cyclamen persicum was not published for anti-inflammatory activity, even though some of its secondary metabolites are very well known for having this activity. Typical search methods were used for finding relevant literature. Finally, the conclusions of this article will be accompanied with recommendations for future research.

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Gundelia tournefortii inhibits hepatocellular carcinoma progression by lowering gene expression of the cell cycle and hepatocyte proliferation in immunodeficient mice

Cited by 6 publications

References 48 publications

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

Anticancer Activity of Thiophene Carboxamide Derivatives as CA-4 Biomimetics: Synthesis, Biological Potency, 3D Spheroid Model, and Molecular Dynamics Simulation

Top Edible Wild Plants of Eastern Mediterranean Region Part II: Anti-inflammatory Activity

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