Gut Bacterial Families Are Associated with Body Composition and Metabolic Risk Markers in School-Aged Children in Rural Mexico

Aguilar, Tania; Nava, Gerardo M.; Olvera-Ramírez, Andrea M.; Ronquillo, Dolores; Camacho, Mariela; Zavala, Gerardo; Caamaño, María del Carmen; Acevedo‐Whitehouse, Karina; Rosado, Jorge L.; Garcı́a, Olga

doi:10.1089/chi.2019.0312

Cited by 21 publications

(20 citation statements)

References 43 publications

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“…It is widely accepted that Lactobacillaceae at the family level and Lactobacillus at the genus level, considered as probiotics, are beneficial gut microbiota for improvement of human health, which play a crucial role in anti-inflammation, production of short-chain fatty acid, and prevention of obesity. − Recently and more strikingly, some works showed that a higher level of Lactobacillaceae was observed in obese mice and patients. , Furthermore, the high abundance of Lactobacillaceae showed positive association with obesity-related features. , Thereinto, Lactobacillus , a taxonomically complex flora that belonged to Lactobacillaceae , is composed of more than 170 species . A recent work showed that some Lactobacillus species such as Lactobacillus reuteri were associated with obesity .…”

Section: Discussionmentioning

confidence: 99%

“…59,60 Furthermore, the high abundance of Lactobacillaceae showed positive association with obesity-related features. 61,62 Thereinto, Lactobacillus, a taxonomically complex flora that belonged to Lactobacillaceae, is composed of more than 170 species. 63 A recent work showed that some Lactobacillus species such as Lactobacillus reuteri were associated with obesity.…”

Section: ■ Discussionmentioning

confidence: 99%

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Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota

Chen

Zhou

et al. 2021

J. Agric. Food Chem.

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There is growing evidence that prevention of metabolic syndrome (MS) by dietary fibers is intricately linked to gut microbiota. In the present work, the mice were fed a high-fat diet (HFD) and orally treated with yeast β-glucan to further examine the effects of β-glucan on MS and gut microbiota and the potential relationship between gut microbiota and its activity. After intervention for 10 weeks, it was found that the treatment of yeast β-glucan could significantly improve the HFD-induced MS. Furthermore, pro-inflammatory cytokines in plasma including IL-6 and IL-1β were decreased. Yeast β-glucan could regulate the diversity and composition of HFD-induced gut microbiota. Moreover, the relative abundances of Lactobacillus and Lactococcus, having significant positive correlation with metabolic changes, were decreased by β-glucan, which might play a critical role in attenuation of MS. Our findings suggest that yeast β-glucan shows promising application as a prebiotic for preventing MS and regulating gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota

Chen

Zhou

et al. 2021

J. Agric. Food Chem.

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“…Recent studies have reported higher levels of Lactobacillaceae in obese mice and patients ( 38 ). Moreover, a high abundance of lactic acid bacteria was positively correlated with obesity-related characteristics ( 39 ). A recent study suggests that some species of lactic acid bacteria, such as Lactobacillus reuteri , are associated with obesity ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Portulaca oleracea polysaccharides reduce serum lipid levels in aging rats by modulating intestinal microbiota and metabolites

Huang

Ding

et al. 2022

Front. Nutr.

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Metabolic diseases characterized by dyslipidemia are common health problems for elderly populations. Dietary fiber intake is inversely associated with the risk of dyslipidemia. This study investigated the effects of Portulaca oleracea polysaccharide (POP) on the intestinal microbiota and its metabolites in aging rats using 16S rRNA sequencing and metabolomics techniques. Our results showed that POPs reduced the ratio of Firmicutes/Bacteroidetes (F/B), relative abundance of Fusobacteria, and levels of triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), and gamma-glutamyl transferase (γ-GT) in the serum of aging rats. POP supplementation also reduced 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol, and vaccenic acid concentrations in lipids and lipoid-like molecules, while soyasapogenol E and monoacylglycerol (MG) (24:0/0:0/0:0) levels increased. This study demonstrated that POP’s beneficial effects on lipid levels in aging rats might be partially attributable to the modification of gut microbiota and related metabolites.

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“…These bacterial families could be considered as anti-obesity markers; for example, S24-7 , as an anti-obesity bacterium, could reduce the proportion of Firmicutes [ 44 ]. The lower abundance of Bacteroidaceae and Rikenellaceae were observed in obese people’s guts [ 45 , 46 ]. Most differentially abundant genera may be both indirectly and directly involved in lipid metabolism, such as Christensenella , SMB53 , and Blautia , having a significant association with host genes ALDH1L1 , GNA12 , and CD36 , which are involved in fatty acids metabolism [ 47 ], while Dorea , Epulopiscium Ruminococcus , and Butyricimonas were involved in fatty acids production [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Host Genotype, Intestinal Sites and Probiotics Supplementation on the Gut Microbiota Composition and Diversity in Sheep

Wang

Zhang

Wang

et al. 2021

Biology

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Three sampling strategies with a 16s rRNA high-throughput sequencing and gene expression assay (by RT-PCR) were designed, to better understand the host and probiotics effect on gut microbiota in sheep. Sampling: (1) colon contents and back-fat tissues from small-tailed Han sheep (SHS), big-tailed Hulun Buir sheep (BHBS), and short-tailed Steppe sheep (SHBS) (n = 12, 14, 12); (2) jejunum, cecum and colon contents, and feces from Tan sheep (TS, n = 6); (3) feces from TS at 4 time points (nonfeeding, 30 and 60 feeding days, and stop feeding 30 days) with probiotics supplementation (n = 7). The results indicated SHS had the highest Firmicutes abundance, the thinnest back-fat, and the lowest expression of C/EBPβ, C/EBPδ, ATGL, CFD, and SREBP1. Some bacteria orders and families could be potential biomarkers for sheep breeds with a distinct distribution of bacterial abundance, implying the host genotype is predominant in shaping unique microbiota under a shared environment. The microbiota diversity and Bifidobacterial populations significantly changed after 60 days of feeding but restored to its initial state, with mostly colonies, after 30 days ceased. The microbiota composition was greatly different between the small and large intestines, but somewhat different between the large intestine and feces; feces may be reliable for studying large intestinal microbiota in ruminants.

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Gut Bacterial Families Are Associated with Body Composition and Metabolic Risk Markers in School-Aged Children in Rural Mexico

Cited by 21 publications

References 43 publications

Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota

Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota

Portulaca oleracea polysaccharides reduce serum lipid levels in aging rats by modulating intestinal microbiota and metabolites

The Impact of Host Genotype, Intestinal Sites and Probiotics Supplementation on the Gut Microbiota Composition and Diversity in Sheep

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