Gut Colonization by Multidrug-Resistant Gram-Negative Bacteria Is an Independent Risk Factor for Development of Intestinal Acute Graft-versus-Host Disease

Perić, Zinaida; Vranješ, Violeta Rezo; Duraković, Nadira; Desnica, Lana; Mareković, Ivana; Serventi‐Seiwerth, Ranka; Nemet, Damir; Biliński, Jarosław; Basak, Grzegorz W.; Vrhovać, Radovan

doi:10.1016/j.bbmt.2017.03.025

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Finally, the role of healthy intestinal microbiota in the prevention of autoimmune diseases has become evident in recent years [52][53][54][55][56]. It seems that gut dysbiosis has an important role in GI GvHD, both in murine models and humans [57][58][59][60][61]. There is also an increasing evidence that intestinal microbiota modulates antitumor immunity [62][63][64][65][66][67].…”

Section: Discussionmentioning

confidence: 99%

Variability of nutritional practices in peritransplant period after allogeneic hematopoietic stem cell transplantation: a survey by the Complications and Quality of Life Working Party of the EBMT

Perić

Botti

Stringer

et al. 2018

Bone Marrow Transplant

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Recommendations on screening and nutritional support for patients undergoing hematopoietic stem cell transplantation (HSCT) have been presented by international nutritional societies, but nutritional practices remain poorly standardized. Following the general policy of the European Society for Blood and Marrow Transplantation (EBMT) to standardize transplantation procedures, the Complications and Quality of Life Working Party and Nursing Research Group carried out a survey among all EBMT centers about their current nutritional practices. The aim of this study was to better understand current practices, differences from available guidelines, and possible barriers for recommended nutritional therapy. Responses from 90 centers (19%) from 23 countries were received. We observed a marked variability in nutritional care between EBMT centers and a substantial lack of standardized operating procedures in screening patients for malnutrition and management of gastrointestinal GVHD. Furthermore, our study confirmed neutropenic diet as standard of care in most centers as well a preference for parenteral nutritional support over enteral. On the basis of these findings, future EBMT efforts will focus on better implementation of international nutritional guidelines into clinical practice.

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Section: Discussionmentioning

confidence: 99%

Variability of nutritional practices in peritransplant period after allogeneic hematopoietic stem cell transplantation: a survey by the Complications and Quality of Life Working Party of the EBMT

Perić

Botti

Stringer

et al. 2018

Bone Marrow Transplant

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“…Another emerging indication to perform fecal microbiota transplantation (FMT) is the gastrointestinal (GI) tract colonization by antibiotic-resistant bacteria (ARB), which is, according to the WHO, one of the biggest threats to global health, food security, and development today [ 197 – 202 ]. ARB gut colonization could be detrimental to the patient when causing infections with gut-colonizing organism or, even resulting in immunologic disorders being a marker of gut dysbiosis [ 203 , 204 ]. Bilinski et al first reported the high efficacy of FMT reaching 60–100% of different ARB decolonization rate after one month from FMT [ 198 , 205 ].…”

Section: Therapeutic Strategies In the Gut Microbiota Manipulationmentioning

confidence: 99%

Microbiota medicine: towards clinical revolution

Gebrayel¹,

et al. 2022

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The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiological functions such as enhancing the host immunity, participating in the nutrient absorption and protecting the body against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between gut microbiota and many organs within the human body such as the intestines, the lungs, the brain, and the skin. Large body of evidence demonstrated, more than a decade ago, that the gut microbial alteration is a key factor in the pathogenesis of many local and systemic disorders. In this regard, a deep understanding of the mechanisms involved in the gut microbial symbiosis/dysbiosis is crucial for the clinical and health field. We review the most recent studies on the involvement of gut microbiota in the pathogenesis of many diseases. We also elaborate the different strategies used to manipulate the gut microbiota in the prevention and treatment of disorders. The future of medicine is strongly related to the quality of our microbiota. Targeting microbiota dysbiosis will be a huge challenge.

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“…Colonisation by MDR organisms adversely impacts survival in early postallogeneic HCT period. 25 , 54 , 55 An Italian multicentre study showed CRE bacteraemia rates of 26% and 39% in CRE colonised autologous and allogenic HCT. 3 Preemptive detection of CRE colonisation is helpful in identifying patients who need early initiation of anti-CRE treatment during their febrile neutropenia episodes and may possibly benefit from gut microbiome restorative strategies before their HCT.…”

Section: Prevention and Treatment Of Cre In Bmt Unitmentioning

confidence: 99%

Prevention and management of carbapenem-resistant Enterobacteriaceae in haematopoietic cell transplantation

Sahitya

Jandiyal

Jain

et al. 2021

Therapeutic Advances in Infection

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Carbapenem-resistant Enterobacteriaceae (CRE) infections are associated with high morbidity and mortality rates in haematopoietic cell transplantation (HCT) recipients. Factors like mucositis, neutropenia, prolonged hospital stay, and frequent use of prophylactic antimicrobials make HCT recipients especially susceptible to CRE infections. Low culture positivity rates, delay in microbiological diagnosis, and resistance to empirical antimicrobial therapy for febrile neutropenia are responsible for high mortality rates in HCT recipients infected with CRE. In this review we discuss the epidemiology, diagnosis, and management of CRE infections with particular emphasis on patients undergoing HCT. We emphasise the need for preventive strategies like multidisciplinary antimicrobial stewardship, and pre-emptive screening for CRE colonisation in prospective HCT patients as measures to mitigate the adverse impact of CRE on HCT outcomes. Newer diagnostic tests like polymerase chain reaction and matrix-assisted laser desorption ionisation-time of flight (MALDI-TOF) assay that enable earlier and better identification of CRE isolates are discussed. Antimicrobial agents available against CRE, including newer agents like ceftazidime-avibactam and meropenem-vaborbactam, have been reviewed. We also discuss the data on promising experimental treatments against CRE: phage therapy and healthy donor faecal microbiota transplant. Finally, this review puts forth recommendations as per existing literature on diagnosis and management of CRE infections in blood and marrow transplant (BMT) unit.

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Gut Colonization by Multidrug-Resistant Gram-Negative Bacteria Is an Independent Risk Factor for Development of Intestinal Acute Graft-versus-Host Disease

Cited by 7 publications

References 9 publications

Variability of nutritional practices in peritransplant period after allogeneic hematopoietic stem cell transplantation: a survey by the Complications and Quality of Life Working Party of the EBMT

Variability of nutritional practices in peritransplant period after allogeneic hematopoietic stem cell transplantation: a survey by the Complications and Quality of Life Working Party of the EBMT

Microbiota medicine: towards clinical revolution

Prevention and management of carbapenem-resistant Enterobacteriaceae in haematopoietic cell transplantation

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