Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies

Wang, Yilun; Wei, Jie; Zhang, Weiya; Doherty, Michael; Zhang, Yuqing; Xie, Hui; Li, Wei; Wang, Ning; Lei, Guanghua; Zeng, Chao

doi:10.1016/j.ebiom.2022.104055

Cited by 67 publications

(49 citation statements)

References 91 publications

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“…These animal findings underscore the importance of the gut microbiome and mycobiome in SpA. In humans, a recently published systemic review and meta-analysis showed a high inconsistency of the intestinal microbial composition in SpA reported in different studies (47) Apart from bacterial microbiota, studies from IBD showed that fungal and viral microbiota are also important in regulating host immunity and maintaining gut homeostasis. A reduction of fungal diversity was observed in IBD patients (58).…”

Section: Gut Microbiome and Spamentioning

confidence: 73%

“…These animal findings underscore the importance of the gut microbiome and mycobiome in SpA. In humans, a recently published systemic review and meta-analysis showed a high inconsistency of the intestinal microbial composition in SpA reported in different studies ( 47 ). Costello et al first identified a distinct microbial composition in the terminal ileum of AS patients, with an increased abundance of 5 families of bacteria ( Lachnospiraceae, Ruminococcaceae, Rikenellacea, Porphyromonadaceae , and Bacteroidaceae ) and a decreased abundance of 2 families of bacteria ( Veillonellaceae and Prevotellaceae ) ( 51 ).…”

Section: Gut Microbiome and Spamentioning

confidence: 75%

“…Gut dysbiosis, an imbalance of microbiota, could increase gut permeability and trigger inflammatory responses, leading to auto-inflammatory diseases such as IBD and asthma ( 45 , 46 ). Alterations in the gut microbiome are also observed in rheumatic diseases ( 47 ). HLA-B27 transgenic germ-free rats fail to develop arthritis and colitis ( 48 ).…”

Section: Gut Microbiome and Spamentioning

confidence: 99%

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Spondyloarthritis: How far are we from precision medicine?

Craemer

Elewaut

et al. 2022

Front. Med.

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Spondyloarthritis (SpA) is a family of heterogenous diseases consisting of different phenotypes. The exact disease mechanism remains unclear but evidence shows the complex pathophysiology with interplay between genome, microbiome, and immunome. Biologic DMARDs have markedly improved patients' disease control and quality of life. However, treatment response varies among patients. There is a growing need to identify biomarkers for the diagnosis, prognosis, prevention, and treatment of SpA. Genomic studies have been the research focus in the past two decades and have identified important genes involved in SpA. In recent years, emerging evidence supports the link between gut and joint inflammation in SpA, in which the role of gut microbiome in SpA is of great interest. Herein, potential genetic and gut microbial biomarkers for predicting treatment response are discussed. Novel strategies targeting dysbiosis in SpA are also summarized. These results represent a significant step toward precision medicine for patients with SpA.

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Section: Gut Microbiome and Spamentioning

confidence: 73%

“…These animal findings underscore the importance of the gut microbiome and mycobiome in SpA. In humans, a recently published systemic review and meta-analysis showed a high inconsistency of the intestinal microbial composition in SpA reported in different studies ( 47 ). Costello et al first identified a distinct microbial composition in the terminal ileum of AS patients, with an increased abundance of 5 families of bacteria ( Lachnospiraceae, Ruminococcaceae, Rikenellacea, Porphyromonadaceae , and Bacteroidaceae ) and a decreased abundance of 2 families of bacteria ( Veillonellaceae and Prevotellaceae ) ( 51 ).…”

Section: Gut Microbiome and Spamentioning

confidence: 75%

Section: Gut Microbiome and Spamentioning

confidence: 99%

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Spondyloarthritis: How far are we from precision medicine?

Craemer

Elewaut

et al. 2022

Front. Med.

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“…However, this finding was only seen in rheumatoid arthritis, systemic lupus erythematosus and polymyalgia while in systemic sclerosis an increase was observed. Another common finding in rheumatoid arthritis, Sjögren’s syndrome and systemic lupus erythematosus was the depletion of anti-inflammatory butyrate-producing microbe (i.e., Faecalibacterium ) and the enrichment of pro-inflammatory microbe (i.e., Streptococcus ) [ 25 ]. The role of gut microbiota in the prototype of ILDs, the IPF is not adequately described.…”

Section: The Microbiome and The Lungmentioning

confidence: 99%

The Role of the Microbiome in Connective-Tissue-Associated Interstitial Lung Disease and Pulmonary Vasculitis

et al. 2022

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The microbiome can trigger and maintain immune-mediated diseases and is associated with the severity and prognosis of idiopathic pulmonary fibrosis, which is the prototype of interstitial lung diseases (ILDs). The latter can be a major cause of morbidity and mortality in patients with connective-tissue diseases (CTD). In the present review, we discuss the current evidence regarding microbiome in CTD-ILD and pulmonary vasculitis. In patients with rheumatoid arthritis (RA) the BAL microbiota is significantly less diverse and abundant, compared to healthy controls. These changes are associated with disease severity. In systemic sclerosis (SSc), gastrointestinal (GI)-dysbiosis is associated with ILD. Butyrate acid administration as a means of restoration of GI-microbiota has reduced the degree of lung fibrosis in animal models. Although related studies are scarce for SLE and Sjögren’s syndrome, studies of the gut, oral and ocular microbiome provide insights into the pathogenesis of these diseases. In ANCA-associated vasculitis, disease severity and relapses have been associated with disturbed nasal mucosa microbiota, with immunosuppressive treatment restoring the microbiome changes. The results of these studies suggest however no causal relation. More studies of the lung microbiome in CTD-ILDs are urgently needed, to provide a better understanding of the pathogenesis of these diseases.

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“…Essa relação pode se estender para alterações na composição das colônias microbianas intestinais, atingindo diversos gêneros bacterianos que podem estar intimamente ligados à patogênese e/ou a sua prevenção (Wang et al, 2022).…”

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Alterações intestinais em pessoas com artrite reumatoide

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Reis

et al. 2022

RSD

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Objetivo: Este estudo objetivou analisar as principais alterações intestinais em pessoas com Artrite Reumatoide (AR) e aspectos relacionados a elas, destacando a influência das alterações alimentares decorrentes dos sintomas intestinais (SI). Métodos: Foram coletados dados quantitativos referentes à faixa etária, ao tempo de diagnóstico da AR, ao perfil evacuatório, aos SI, à influência da alimentação nos sintomas e aos aspectos socioeconômicos através da implementação de um questionário adaptado validado (Souza et al., 2016) em grupos de redes sociais virtuais. Cruzamentos entre esses dados foram realizados para esclarecer melhor os principais fatores envolvidos nessa correlação. Os resultados foram calculados através do programa Statistical Packages of the Social Sciences®. Resultados: Participaram 91 pessoas com AR, com média de idade de 46,9 anos; 96,7% eram do sexo feminino e 3,3% do sexo masculino. Foi revelada uma ocorrência enfática de SI nos portadores de AR. Os principais sintomas relatados foram dor abdominal, náusea, flatulência, constipação e diarreia. Houve prevalência significativa de dor abdominal ao relacionar SI com faixa etária. 97,8% afirmaram usar medicamentos para tratar a AR e 2,2% negaram. Por decorrência dos SI, em que “constipação” e “náusea” foram estatisticamente significantes, 68% relataram mudanças na alimentação. Os resultados também mostraram independência entre SI e o perfil socioeconômico dos respondentes. Conclusão: Foi verificada a elevada prevalência de alterações intestinais em portadores de AR e mudanças alimentares em decorrência dos SI.

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Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies

Cited by 67 publications

References 91 publications

Spondyloarthritis: How far are we from precision medicine?

Spondyloarthritis: How far are we from precision medicine?

The Role of the Microbiome in Connective-Tissue-Associated Interstitial Lung Disease and Pulmonary Vasculitis

Alterações intestinais em pessoas com artrite reumatoide

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