Gut Hormones and Regulation of Food Intake in Birds

Honda, Kazuhisa; Saneyasu, Takaoki; Kamisoyama, Hiroshi

doi:10.2141/jpsa.0160100

Cited by 34 publications

(24 citation statements)

References 102 publications

(124 reference statements)

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“…However, the molecular mechanisms underlying the IGF-1-induced anorexia in chicks have not been investigated. Physiological and molecular mechanisms involved in the regulation of food intake in chickens have recently been investigated (Kuenzel, 1994, Richard andProszkowiec-Weglarz, 2007;Honda et al, 2017). In mammals and birds, two neuronal populations within the hypo-thalamus, namely, the orexigenic neuropeptide Y(NPY)/agoutirelated protein (AgRP) neurons and the anorexigenic proopiomelanocortin (POMC) neurons, are believed to be critical conduits via which peripheral signals are integrated to alter the drive to eat (Bungo et al, 2011;Sam et al, 2012;Zeltser et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

et al. 2019

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Insulin-like growth factor-1 (IGF-1) is a key regulator of muscle development and metabolism in chickens. Recently, we have demonstrated that intracerebroventricular administration of IGF-1 significantly decreased food intake in broiler chicks. However, the molecular mechanisms underlying the IGF-1-induced anorexia and the anorexigenic effect of IGF-1 in different strains of commercial chicks have not been investigated. Neuropeptide Y (NPY, a hypothalamic orexigenic neuropeptide), agouti-related protein (AgRP, a hypothalamic orexigenic neuropeptide), and proopiomelanocortin (POMC, the precursor of hypothalamic anorexigenic neuropeptides) play important roles in the regulation of food intake in both mammals and chickens. Evidence shows that several cell signaling pathways in the hypothalamus are involved in regulating the feeding behavior of mammals. In the present study, we first investigated the effects of IGF-1 on the expression of appetite-regulating neuropeptides and phosphorylation of signaling molecules in the hypothalamus of broiler chicks. Intracerebroventricular administration of IGF-1 significantly increased the mRNA levels of POMC, whereas the mRNA levels of NPY and AgRP were not significantly altered. IGF-1 also significantly induced the phosphorylation of v-Akt murine thymoma viral oncogene homolog 1 (AKT) in the hypothalamus of chicks, but did not influence the phosphorylation of forkhead box O1, S6 protein, AMP-activated protein kinase, and extracellular signal-regulated kinase 1/2. We also compared the effect of IGF-1 on food intake in broiler chicks (a hyperphagic strain of chickens) and layer chicks. Results demonstrated that the threshold of IGF-1-induced anorexia in broiler chicks was higher than that in layer chicks. Our observations suggest that hypothalamic POMC and AKT may be involved in the IGF-1-induced anorexigenic pathway and that high threshold of IGF-1-induced anorexia in broiler chicks might be one of the causes of hyperphagia in broiler chicks. Overall, it appears that IGF-1 plays important roles in the central regulation of feeding behavior in chicks.

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Section: Introductionmentioning

confidence: 99%

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

et al. 2019

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“…Therefore, gut mucosa plays a crucial role in bird's physiology since it must be permeable to nutrients, electrolytes and water, and at the same time is a barrier against bacteria and antigens translocation to the lamina propria. In addition, the small intestine also has an important immunological, endocrine and regulatory function (Scanes & Pierzchala-Koziec, 2014) which can deeply affect health status (Sugiharto, 2016), as well as feeding behaviour and overall energy homeostasis in the chickens (Honda, Saneyasu, & Kamisoyama, 2017).…”

Section: Introductionmentioning

confidence: 99%

Differences in productive performance and intestinal transcriptomic profile in two modern fast‐growing chicken hybrids

Zampiga

Bertocchi

Bosi

et al. 2018

Animal Physiology Nutrition

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This study aimed to characterize growth performance and ileum transcriptomic profile of two fast‐growing chicken hybrids (HA and HB). A total of 1,170 one‐day‐old female chicks (n = 585 per genotype) were weighed and randomly divided into 18 pens (9 replications/group). Both the groups received the same commercial diet (starter, 0–9 days; grower I, 10–21 days; grower II, 22–34 days; and finisher, 35–43 days). Body weight (BW), daily feed intake (DFI) and feed conversion ratio (FCR) were determined on a pen basis at the end of each feeding phase. At the processing (43 days), incidence of footpad dermatitis (FPD) was evaluated on all the birds and ileum mucosa was collected from 1 bird/replication. Total mRNA was extracted to perform microarray analysis (Chicken Gene 1.1ST Array Strip), and an exploratory pathway analysis was then conducted (Gene Set Enrichment Analysis software). The two genotypes showed different growth patterns throughout the study. HA birds exhibited higher BW and better FCR than HB after 9 days (228 vs. 217 g and 1.352 vs. 1.419, respectively, p < 0.05). At 21, 34 and 43 days, HB birds reported higher BW (807 vs. 772 g; 1,930 vs. 1,857 g and 2,734 vs. 2,607 g, respectively; p < 0.01), DFI (74.9 vs. 70.6 g bird−1 day−1, p < 0.01; 144.4 vs. 139.6 g bird−1 day−1, p = 0.06; and 196.5 vs. 182.4 g bird−1 day−1, p < 0.01) and similar FCR compared to HA ones. HB group showed a higher percentage of birds with no FPD (75% vs. 48%; p < 0.001). Transcriptomic analysis revealed enriched gene sets for mitochondria, cellular energy metabolism, and cell structure and integrity in ileum mucosa of HA broilers and enriched gene sets for immune system activation, cell signalling and inflammation in HB ones. In conclusion, these results indicated that the two chicken genotypes are characterized by different growth patterns, feeding behaviour and gene expression profiles in the intestinal mucosa.

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“…It stimulates insulin secretion from the pancreatic islets in mammalian species. The mRNA of proglucagon, which acts as the precursor of GLP-1, is highly expressed in the ileum of the chicken alimentary tract (Honda et al, 2017). In chickens, GLP-1 is stored in the secretory granules of L cells, which are mainly distributed in the distal ileum (Hiramatsu et al, 2003(Hiramatsu et al, , 2005Nishimura et al, 2013) and is secreted in response to dietary protein and amino acids (Monir et al, 2014a;Nishimura et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

et al. 2018

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Glucagon-like peptide (GLP)-1 is released from the intestinal L cells in response tofood ingestion and stimulates insulin secretion from the pancreatic B cells, by binding to its specific receptor (GLP-1R), which is expressed on the pancreatic B cells in the mammalian pancreas. Previously, we demonstrated that chicken GLP-1R was expressed on the pancreatic D cells by using a specific antibody against chicken GLP-1R. In the present study, we compared the localization of GLP-1R in the pancreases of three avian species; white leghorn chicken, northern bobwhite, and common ostrich, using the double immunofluorescence technique. We found that the types of pancreatic islets in the northern bobwhite pancreas were similar to those found

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Gut Hormones and Regulation of Food Intake in Birds

Cited by 34 publications

References 102 publications

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

Differences in productive performance and intestinal transcriptomic profile in two modern fast‐growing chicken hybrids

Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches

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