Gut microbial and short-chain fatty acid profiles in adults with chronic constipation before and after treatment with lubiprostone

Kang, Dae Wook; DiBaise, John K.; Ilhan, Zehra Esra; Crowell, Michael D.; Rideout, Jai Ram; Caporaso, J. Gregory; Rittmann, Bruce E.; Krajmalnik‐Brown, Rosa

doi:10.1016/j.anaerobe.2015.01.005

Cited by 52 publications

(46 citation statements)

References 82 publications

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“…Previous studies described the changes in the gut microbiota of patients with constipation, which are characterized by a relative decrease in the Bifidobacterium and Lactobacillus species and an increase in potentially pathogenic microorganisms [39]. Previous studies reported no significant differences in the microbial profiles of patients with constipation and healthy subjects [4]. The conflicting results might also relate to differences in the definition of constipation in the various studies.…”

Section: Discussionmentioning

confidence: 99%

“…Butyrate and other SCFAs have also been shown to provide protection against colon cancer [43]. Compared with other similar investigations, some have observed significantly higher levels of isobutyrate in samples from subjects with constipation than in those from healthy subjects [4], and others reported increases in butyrate levels [44]. These phenomena might be related to diet because SCFAs originate from the degradation of polysaccharides, which increases when the system operates with longer retention times [45].…”

Section: Discussionmentioning

confidence: 99%

“…Reports have shown that constipation and diarrhea are associated with gut microbes. The relative abundance of pathogens (methanogenic archaea [4] and clostridia [5]) increases in patient with constipation, and the relative abundance of enteropathogenic bacteria ( Salmonella , Shigella , enterotoxigenic Escherichia coli , or Vibrio cholera ) increases in patients with diarrhea [6,7], which disturbs the ecological balance in the intestines [8]. As research into the intestinal micro-ecology continues to develop, it is understandable to attempt treatment of constipation with intestinal micro-ecological therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical studies have shown that gut microbiota in constipation differs from that in healthy subjects [12,13] and is mainly manifested in the levels of Bifidobacterium , Lactobacillus and pathogenic bacteria. Most studies have shown that changes in the intestinal flora in the constipation group mainly involve a decrease in Bifidobacteria and Lactobacilli and an increase in pathogenic bacteria (methanogenic archaea [4] and clostridia [5]). Therefore, supplementation with probiotics has become a new method to treat constipation.…”

Section: Introductionmentioning

confidence: 99%

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Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Wang

et al. 2017

IJMS

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Constipation is one of the most common gastrointestinal complaints worldwide. This study was performed to determine whether Bifidobacterium adolescentis exerts inter-strain differences in alleviating constipation induced by loperamide in BALB/c mice and to analyze the main reasons for these differences. BALB/c mice underwent gavage with B. adolescentis (CCFM 626, 667, and 669) once per day for 17 days. The primary outcome measures included related constipation indicators, and the secondary outcome measures were the basic biological characteristics of the strains, the concentration changes of short-chain fatty acids in feces, and the changes in the fecal flora. B. adolescentis CCFM 669 and 667 relieved constipation symptoms by adhering to intestinal epithelial cells, growing quickly in vitro and increasing the concentrations of propionic and butyric acids. The effect of B. adolescentis on the gut microbiota in mice with constipation was investigated via 16S rRNA metagenomic analysis. The results revealed that the relative abundance of Lactobacillus increased and the amount of Clostridium decreased in the B. adolescentis CCFM 669 and 667 treatment groups. In conclusion, B. adolescentis exhibits strain-specific effects in the alleviation of constipation, mostly due to the strains’ growth rates, adhesive capacity and effects on the gut microbiome and microenvironment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Wang

et al. 2017

IJMS

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“…But the number of defecation alone is not a sufficient criterion. Amount of stool is also important as the number of defecation (2)(3)(4). Constipation is a very common gastrointestinal problem in the community (ranging from 2% to 28%) (2,5,6).…”

Section: Introductionmentioning

confidence: 99%

Turkish reliability of National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS®) constipation scale

Mamur¹,

Kayhan²,

Bilge³

et al. 2017

J Turgut Ozal Med Cent

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Objective: Scales can be used to determine the cause of constipation which is one of the gastrointestinal symptoms. In this study; our aim was to perform reliability study of the Turkish version of National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS®) Constipation Scale. Materiel and Methods: The Constipation scale was translated into Turkish by three researchers, and a consensus meeting was held after the translation process. The Turkish text on which the researchers agreed was translated into English by an independent professional translator. The researchers decided that there was no difference between the translated English text and the source text after they compared the two texts in terms of meaning and comprehensibility. As a result of this process, the researchers obtained the final version on which they agreed and the accuracy of which was proved by back translation. Results: A total of 63 patients took part in this study. 32 of them (50.8%) were male, 31 of them (49.2%) were female. mean age of participants was 40,25±16,18 years. Mean questionnaire score was 11,38 ± 2,95. Cronbach's alpha coefficient was found to be 0.758 for 9 scale question. Discussion: This study shows that Turkish version of PROMIS-Constipation scale is reliable. We believe that this scale may be used for the objective assessment of patients with constipation in clinical practice.

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Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice

Long

Liu

et al. 2020

Food Science & Nutrition

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Constipation is one of the most common functional gastrointestinal disorders accompanied with intestinal dysbiosis. Laxatives for constipation usually have side effects. Bee honey is a natural food with unique composition, antimicrobial properties, and bifidogenic effect. In order to assess whether honey can ameliorate loperamide‐induced constipation in BALB/c mice through the alteration of the gut microbiota, the present study was undertaken. Mice were given Jarrah honey (7.5 g/kg body weight) by gavage once per day for 5 days. Fecal water content, intestinal transit rate together with the colon concentrations of substance P (SP), vasoactive intestinal peptide (VIP), and serotonin (5‐hydroxytryptamine; 5‐HT) were evaluated. Furthermore, we determined the effect of honey treatment on gut microbiota in mice using stool genomic 16S rRNA sequencing. As a result, honey showed an obvious improvement in fecal water content and alleviated constipation by modulating the microbial composition of the microbiota, and this was highly associated with a proportional decrease in gut Desulfovibrio. In addition, we found that the colon level of neurotransmitters SP and VIP was significantly related to microbial variations. Our results indicate that gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice, and it could be considered as an evaluating parameter in constipation therapy strategies.

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Gut microbial and short-chain fatty acid profiles in adults with chronic constipation before and after treatment with lubiprostone

Cited by 52 publications

References 82 publications

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Turkish reliability of National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS®) constipation scale

Gut microbiota is involved in the alleviation of loperamide‐induced constipation by honey supplementation in mice

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