Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies

Costanzo, Margherita Di; Carucci, Laura R.; Canani, Roberto Berni; Biasucci, Giacomo

doi:10.3390/ijms21155275

Cited by 25 publications

(16 citation statements)

References 117 publications

(158 reference statements)

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“…The metabolism, homeostasis, and immune system of gut are maintained with the help of gut microbiome. When their populations or living conditions are “dysregulated”, it may lead to metabolic abnormalities; inflammation; and other diseases, such as obesity [ 7 ], type 2 diabetes mellitus [ 8 ], and food allergies [ 9 ]. Moreover, an increasing number of studies have shown that the gut microbiome plays an important role in tumorigenesis and tumor progression, such as breast cancer [ 10 ], prostate cancer [ 11 ], and colorectal cancer [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Integrated Analysis of the Fecal Metagenome and Metabolome in Bladder Cancer in a Chinese Population

Qin

Chen

Cao

et al. 2022

Genes

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Bladder cancer (BLCA) is a common malignancy of the urinary system. The gut microbiome produces various metabolites that play functional roles in tumorigenesis and tumor progression. However, the integrative analysis of the gut microbiome and metabolome in BLCA has still been lacking. Thus, the aim of this study was to identify microbial and functional characteristics and metabolites in BLCA in a Chinese population. Metagenomics, targeted metabolomics, bioinformatics, and integrative analysis were used in fecal samples of BLCA patients and healthy individuals. We found gut microbiomes were significantly dysregulated in BLCA patients, including Bifidobacterium, Lactobacillus, Streptococcus, Blautia, and Eubacterium. We also found 11Z-eicosenoic acid, 3-methoxytyrosine, abrine, aniline-2-sulfonate, arachidic acid, conjugated linoleic acids, elaidic acid, glycylleucine, glycylproline, leucyl-glycine, linoelaidic acid, linoleic acid, nicotinamide hypoxanthine dinucleotide, oleic acid, petroselinic acid, and ricinoleic acid to be significantly decreased, while cholesterol sulfate was significantly increased in BLCA patients. Integration of metagenomics and metabolomics revealed interactions between gut microbiota and metabolites and the host. We identified the alterations of gut microbiomes and metabolites in BLCA in a Chinese population. Moreover, we preliminarily revealed the associations between specific gut microbiomes and metabolites. These findings determined potential causative links among gut dysbiosis, dysregulated metabolites, and BLCA.

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Section: Introductionmentioning

confidence: 99%

Integrated Analysis of the Fecal Metagenome and Metabolome in Bladder Cancer in a Chinese Population

Qin

Chen

Cao

et al. 2022

Genes

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“…In addition, butyrate is the only SCFA produced exclusively by gut microbial fermentation, while others are influenced by host metabolism [186]. Recent findings support the hypothesis that butyrate might contribute to the development of immune oral tolerance and the prevention and treatment of food allergies [187][188][189].…”

Section: The Role Of (Oral And) Gut Microbiota In Food Allergymentioning

confidence: 68%

The Role of Early Life Microbiota Composition in the Development of Allergic Diseases

Tuniyazi

et al. 2022

Microorganisms

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Allergic diseases are becoming a major healthcare issue in many developed nations, where living environment and lifestyle are most predominantly distinct. Such differences include urbanized, industrialized living environments, overused hygiene products, antibiotics, stationary lifestyle, and fast-food-based diets, which tend to reduce microbial diversity and lead to impaired immune protection, which further increase the development of allergic diseases. At the same time, studies have also shown that modulating a microbiocidal community can ameliorate allergic symptoms. Therefore, in this paper, we aimed to review recent findings on the potential role of human microbiota in the gastrointestinal tract, surface of skin, and respiratory tract in the development of allergic diseases. Furthermore, we addressed a potential therapeutic or even preventive strategy for such allergic diseases by modulating human microbial composition.

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“…In addition, butyrate is the only SCFA produced exclusively by gut microbial fermentation, while others are influenced by host metabolism (159). Recent findings support the hypothesis that butyrate might contribute to the development of immune oral tolerance and in the prevention and treatment of food allergies (160)(161)(162).…”

Section: The Role Of (Oral And) Gut Microbiota In Food Allergymentioning

confidence: 69%

The Role of Early Life Gut Microbiota Composition in the Development of Allergic Diseases

Tuniyazi¹,

Li²,

Hu³

et al. 2022

Preprint

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Allergic diseases are becoming a major healthcare issue in many developed nations, where living environment and lifestyle are most predominantly distinct. Such differences include urbanized, industrialized living environments, overused hygiene products, antibiotics, stationary lifestyle, and fast-food based diets tend to reduce microbial diversity and lead to impared immune protection, which further increase the development of allergic diseases. In the same time, studies also showed that modulating microbiomes can ameliorate allergic symptoms. Therefore, in this paper, we aimed to review recent findings on the potential role of the human microbiome in the gastrointestinal tract, surface of skin and respiratory tract for the development of allergic diseases. Furthermore, we addressed a potential therapeutic or even preventive strategy for such allergic diseases by modulating the human microbial composition.

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Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies

Cited by 25 publications

References 117 publications

Integrated Analysis of the Fecal Metagenome and Metabolome in Bladder Cancer in a Chinese Population

Integrated Analysis of the Fecal Metagenome and Metabolome in Bladder Cancer in a Chinese Population

The Role of Early Life Microbiota Composition in the Development of Allergic Diseases

The Role of Early Life Gut Microbiota Composition in the Development of Allergic Diseases

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