2021
DOI: 10.35845/kmuj.2021.20739
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Gut Microbiome Profile in Zinc Deficient Infants Using Next Generation Sequencing

Abstract: neonates. The formula milk is concerned to impair the immune system of an infant and develops metabolic syndromes in 10 adult life. It is evident from literature that the breast milk microbiome varies from colostrum to late lactational phases, maternal health status and gestational 11 age. Few dominating genera in breast milk are Streptococcus, Staphylococcus,

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“…Specifically, in vitro reactors of the human colon microbiota demonstrated that ZnONP exposure at high concentrations significantly reduced the abundance of gut microbiota, as well as decreased bacterial biodiversity, SCFA production, and antibiotic resistance genes, which was associated with an increase in relative abundance of Bacteroidetes and a lower percentage of Firmicutes ( Zhang et al, 2021 ). A preliminary study in a cohort of Pakistani children demonstrated that formula-fed children with Zn deficiency are characterized by lower abundance of Escherichia , as well as decreased relative number of Veillonella, Streptococcus , Bacteroides , Leuconostoc, Subdoligranulum, Megaspheare, and Clostridia ( Durrani et al, 2021 ). However, correlation analysis did not reveal a strong association between serum Zn levels and intestinal bacteria ( Durrani et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
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“…Specifically, in vitro reactors of the human colon microbiota demonstrated that ZnONP exposure at high concentrations significantly reduced the abundance of gut microbiota, as well as decreased bacterial biodiversity, SCFA production, and antibiotic resistance genes, which was associated with an increase in relative abundance of Bacteroidetes and a lower percentage of Firmicutes ( Zhang et al, 2021 ). A preliminary study in a cohort of Pakistani children demonstrated that formula-fed children with Zn deficiency are characterized by lower abundance of Escherichia , as well as decreased relative number of Veillonella, Streptococcus , Bacteroides , Leuconostoc, Subdoligranulum, Megaspheare, and Clostridia ( Durrani et al, 2021 ). However, correlation analysis did not reveal a strong association between serum Zn levels and intestinal bacteria ( Durrani et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…A preliminary study in a cohort of Pakistani children demonstrated that formula-fed children with Zn deficiency are characterized by lower abundance of Escherichia , as well as decreased relative number of Veillonella, Streptococcus , Bacteroides , Leuconostoc, Subdoligranulum, Megaspheare, and Clostridia ( Durrani et al, 2021 ). However, correlation analysis did not reveal a strong association between serum Zn levels and intestinal bacteria ( Durrani et al, 2021 ). Similarly, humans with the SLC39A8 A391T variant exhibited significantly altered gut microbiota communities, including reduced abundance of Anaerostipes, Coprococcus, Roseburia, Lachnospira, SMB53, Ruminococcaceae, Eubacterium, Dorea, and Bacteroides .…”
Section: Introductionmentioning
confidence: 99%