Gut Microbiota and Coronary Artery Disease

Yamashita, Tomoya; Emoto, Takuo; Sasaki, Naoto; Hirata, Ken‐ichi

doi:10.1536/ihj.16-414

Cited by 66 publications

(48 citation statements)

References 59 publications

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“…Bacillus. 66 A research showed that the structural changes in the GM could be used as a diagnostic marker for coronary heart disease. 67 Using a high-choline diet to feed ApoE-/-C57BL mice, results display that higher the serum TMAO level in mice, larger was the area of the sizeable atherosclerotic plaque .…”

Section: Coronary Heart Diseasementioning

confidence: 99%

Endocrine organs of cardiovascular diseases: Gut microbiota

Jia

Xie

et al. 2019

J Cellular Molecular Medi

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Gut microbiota ( GM ) is a collection of bacteria, fungi, archaea, viruses and protozoa , etc. They inhabit human intestines and play an essential role in human health and disease. Close information exchange between the intestinal microbes and the host performs a vital role in digestion, immune defence, nervous system regulation, especially metabolism, maintaining a delicate balance between itself and the human host. Studies have shown that the composition of GM and its metabolites are firmly related to the occurrence of various diseases. More and more researchers have demonstrated that the intestinal microbiota is a virtual ‘organ’ with endocrine function and the bioactive metabolites produced by it can affect the physiological role of the host. With deepening researches in recent years, clinical data indicated that the GM has a significant effect on the occurrence and development of cardiovascular diseases ( CVD ). This article systematically elaborated the relationship between metabolites of GM and its effects, the relationship between intestinal dysbacteriosis and cardiovascular risk factors, coronary heart disease, myocardial infarction, heart failure and hypertension and the possible pathogenic mechanisms. Regulating the GM is supposed to be a potential new therapeutic target for CVD .

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Section: Coronary Heart Diseasementioning

confidence: 99%

Endocrine organs of cardiovascular diseases: Gut microbiota

Jia

Xie

et al. 2019

J Cellular Molecular Medi

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“…A total of 524 OUTs were obtained from 50 samples of all the groups. The valid data were clustered by taxon, OTUs abundance and Alpha/Beta diversity analysis [9]. The most abundant sequence was selected from each OTU as the representative sequence.…”

Section: Bioinformatics and Sequencing Data Analysismentioning

confidence: 99%

“…In recent years, with the development of genomics and molecular biology technologies, the relationship between intestinal microorganisms and the occurrence and development of diseases has attracted great attention [9][10][11][12]. The gastrointestinal tract is the largest microbial colonized organ in the body, as it maintains intestinal bacteria.…”

Section: Introductionmentioning

confidence: 99%

Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice

Liu

et al. 2019

Marine Drugs

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Normal intestinal flora is widely involved in many functions of the host: nutritional metabolism; maintenance of intestinal microecological balance; regulation of intestinal endocrine function and nerve signal transduction; promotion of intestinal immune system development and maturation; inhibition of pathogenic bacteria growth and colonization, reduction of its invasion to intestinal mucosa, and so on. In recent years, more and more studies have shown that intestinal flora is closely related to the occurrence, development, and treatment of various tumors. It is indicated that recombinant phycoerythrin (RPE) has significant anti-tumor and immunomodulatory effects. However, little is known about the mechanism of the effect of oral (or intragastric) administration of RPE on gut microbiota in tumor-bearing animals. In this study, using high-throughput 16S rDNA sequencing, we examined the response of gut microbiota in H22-bearing mice to dietary RPE supplementation. The results showed that the abundance of beneficial bacteria in the mice intestinal flora decreased and that of the detrimental flora increased after inoculation with tumor cells (H22); following treatment with dietary RPE, the abundance of beneficial bacteria in the intestinal flora significantly increased and that of detrimental bacteria decreased. In this study, for the first time, it was demonstrated that dietary RPE could modulate the gut microbiota of the H22 bearing mice by increasing the abundance of beneficial bacteria and decreasing that of detrimental bacteria among intestinal bacteria, providing evidence for the mechanism by which bioactive proteins affect intestinal nutrition and disease resistance in animals.

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“…This may partially explain the beneficial effects of the so called Mediterranean diet, which is little atherogenic. Despite evidences, it is not clear whether the modification of the gut microbiota precedes metabolic changes or simply coincides with them, and causality cannot be ascertained (8).…”

Section: The Obesity Epidemicsmentioning

confidence: 99%

The gut and the heart: a concise narrative review

Lamas¹

2019

HVT

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Foods have a wider role besides simply satisfying hunger, and the gut may be the source of several diseases. The human gut is populated by 100 trillion microorganisms and the most abundant phyla are the Firmicutes ( 60 a 80%), such as the lactobacilli, and the Bacteroidetes ( 20 a 40%), such as the gender Bacteroides.The obesity epidemics may be related to the constant availability of food, less physical exercise, and influences on the gut microbiota such as type of food ingested (low fiber, high calorie, and high fat). The beneficial effects of the gut microbiota result partly from products derived from the fermentation of nondigestible carbohydrates (fibers), which generate short chain fatty acids, which in turn influence hormones that stimulate insulin secretion, improve insulin receptor sensitivity, promote satiety and inhibit glucagon secretion. Obese individuals have increased intestinal permeability and LPS release may promote, through metabolic endotoxaemia, an inflammatory state, such as seen in type II diabetes mellitus and obesity. Chronic heart failure results in a decreased perfusion of the gastrointestinal tract, with edema, dysmotility and malabsorption, which facilitates LPS release, which may induce negative inotropic effects, myocardial hypertrophy, fibrosis and apoptosis via tumor necrosis factor (TNF)-α, interleukin (IL)-1 and IL-6. Trimethylamine-N-oxide (TMAO) is a microbiota derived metabolite and is pro-atherogenic. Eating healthy and making judicious use of antibiotics may promote cardiovascular health via effects on the gut microbiota.

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Gut Microbiota and Coronary Artery Disease

Cited by 66 publications

References 59 publications

Endocrine organs of cardiovascular diseases: Gut microbiota

Endocrine organs of cardiovascular diseases: Gut microbiota

Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice

The gut and the heart: a concise narrative review

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