Gut microbiota and obesity: Involvement of the adipose tissue

Guida, Sonia; Venema, Koen

doi:10.1016/j.jff.2015.02.014

Cited by 38 publications

(31 citation statements)

References 58 publications

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“…Current dietary interventions include use of plantbased bioactive ingredients like soluble fibres and soy proteins. Similarly inulin-type fructans alter the digestion, metabolism and absorption of lipids resulting in the reduction of serum lipids as well as redistribution of lipids among various lipoproteins (Guida & Koen, 2015).…”

Section: Hypocholesterolaemic Perspectivesmentioning

confidence: 99%

Prebiotics, gut microbiota and metabolic risks: Unveiling the relationship

Yasmin

Butt

Afzaal

et al. 2015

Journal of Functional Foods

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Section: Hypocholesterolaemic Perspectivesmentioning

confidence: 99%

Prebiotics, gut microbiota and metabolic risks: Unveiling the relationship

Yasmin

Butt

Afzaal

et al. 2015

Journal of Functional Foods

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“…Interestingly, increasing evidence suggests that the gut microbiota plays an important role in human obesity (Harris et al 2012;Aguirre et al 2014;Guida and Venema 2015). Several important discoveries have been made from which we highlight: (i) the impact of dietary components on the composition of gut microbiota.…”

Section: Introductionmentioning

confidence: 93%

“…(ii) the effects of gut microbiota composition and activity on mucosal and systemic immune responses and energy metabolism (Requena et al 2013). Obesity is generally accepted as a state of chronic, low-grade inflammation (Guida and Venema 2015). Findings suggest that the increase in the uptake of lipopolysaccharide (LPS), a molecule released by Gram-negative bacteria in the gut, and the permeability of the intestine induce a systemic inflammation (Requena et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, commensal mucosal bacteria interacting with the mucus layer may also have an effect on obesity as shown by Everard et al (2013) who inversely correlated the abundance of A. muciniphila and obesity. Last but not least, it has been found that metabolites produced from the fermentation of indigestible dietary compounds serve as energy source to the host (''energy harvest'' hypothesis) and they have been proposed to mediate (indirectly) the release of satiety hormones (Guida and Venema 2015).…”

Section: Introductionmentioning

confidence: 99%

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The art of targeting gut microbiota for tackling human obesity

Aguirre

Venema

2015

Genes Nutr

Self Cite

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Recently, a great deal of interest has been expressed regarding strategies to tackle worldwide obesity because of its accelerated wide spread accompanied with numerous negative effects on health and high costs. Obesity has been traditionally associated with an imbalance in energy consumed when compared to energy expenditure. However, growing evidence suggests a less simplistic event in which gut microbiota plays a key role. Obesity, in terms of microbiota, is a complicated disequilibrium that presents many unclear complications. Despite this, there is special interest in characterizing compositionally and functionally the obese gut microbiota with the help of in vitro, animal and human studies. Considering the gut microbiota as a factor contributing to human obesity represents a tool of great therapeutic potential. This paper reviews the use of antimicrobials, probiotics, fecal microbial therapy, prebiotics and diet to manipulate obesity through the human gut microbiota and reveals inconsistencies and implications for future study.

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“…A prolonged period of imbalance between energy intake and expenditure, owing to a high caloric diet and lack of physical activity, stimulates the increased storage of energy in the form of triacylglycerols (TGs) in adipocytes, which leads to an increase in adipose tissue mass, body weight, and, eventually, to obesity. The pathogenesis and clinical presentations of obesity result from complex interactions between the adipose tissues, gastrointestinal (GI) system, central nervous system, peripheral nervous system, and gut microbiota; it is a multifactorial disease . An accumulation of evidence suggests that the communication among nutrients, neuropeptides, hormones, adipokines, and inflammatory mediators derived from specific organs, tissues, or cell types play important roles in the complicated pathogenesis of obesity .…”

Section: Introductionmentioning

confidence: 99%

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Pan

et al. 2018

BioFactors

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Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications. Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies. Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity. Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases. © 2018 BioFactors, 44(1):50-60, 2018.

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Gut microbiota and obesity: Involvement of the adipose tissue

Cited by 38 publications

References 58 publications

Prebiotics, gut microbiota and metabolic risks: Unveiling the relationship

Prebiotics, gut microbiota and metabolic risks: Unveiling the relationship

The art of targeting gut microbiota for tackling human obesity

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

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