Gut Microbiota and Type 1 Diabetes

Han, Hui; Li, Yuying; Fang, Jun; Liu, Gang; Yin, Jie; Li, Tiejun; Yin, Yulong

doi:10.3390/ijms19040995

Cited by 164 publications

(129 citation statements)

References 84 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Diabetes. Micobiome analysis has been performed in a few studies to elucidate the role of microbiota in driving the pathogenesis of diabetes mellitus [120][121][122]. In the context of fungal involvement, Soyucen and collaborators found that besides Echerichia coli, C. albicans and Enterobacteriaceae colonization were increased in the patients with type 1 diabetes mellitus (T1DM), whereas Bifidobacterium colonization was reduced [123].…”

Section: Inflammatory Bowel Syndromes (Ibs)mentioning

confidence: 99%

Mycobiome in the Gut: A Multiperspective Review

Chin

Yong

Chong

et al. 2020

Mediators of Inflammation

107

View full text Add to dashboard Cite

Human gut is home to a diverse and complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi, and other microorganisms that have an undisputable role in maintaining good health for the host. Studies on the interplay between microbiota in the gut and various human diseases remain the key focus among many researchers. Nevertheless, advances in sequencing technologies and computational biology have helped us to identify a diversity of fungal community that reside in the gut known as the mycobiome. Although studies on gut mycobiome are still in its infancy, numerous sources have reported its potential role in host homeostasis and disease development. Nonetheless, the actual mechanism of its involvement remains largely unknown and underexplored. Thus, in this review, we attempt to discuss the recent advances in gut mycobiome research from multiple perspectives. This includes understanding the composition of fungal communities in the gut and the involvement of gut mycobiome in host immunity and gut-brain axis. Further, we also discuss on multibiome interactions in the gut with emphasis on fungi-bacteria interaction and the influence of diet in shaping gut mycobiome composition. This review also highlights the relation between fungal metabolites and gut mycobiota in human homeostasis and the role of gut mycobiome in various human diseases. This multiperspective review on gut mycobiome could perhaps shed new light for future studies in the mycobiome research area.

show abstract

Section: Inflammatory Bowel Syndromes (Ibs)mentioning

confidence: 99%

Mycobiome in the Gut: A Multiperspective Review

Chin

Yong

Chong

et al. 2020

Mediators of Inflammation

107

View full text Add to dashboard Cite

show abstract

“…In such acquired endocrinological diseases as obesity, type 2 diabetes (not related to heredity) can be attributed to pathological conditions due to metabolic disorders involving the microbiota. Microbiota can influence the development of diabetes [19]. Changes in the microbiological composition-dysbacteriosiscaused, for example, by the use of antibiotics, may contribute to an increase in insulin dysfunction, a long-term consequence of which is the development of type 2 diabetes.…”

Section: Microbiota Dysfunction In Pathology 31 Diseases Of the Digementioning

confidence: 99%

Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology

Белобородова¹,

Grechko²,

Olenin³

2020

Metabolomics - New Insights Into Biology and Medicine

View full text Add to dashboard Cite

In the twenty-first century, metabolomics allowed evaluating the profile of metabolites of various classes of compounds in the human body. The most important achievement of the metabolic approach is to obtain evidence of the intersection of human biochemical pathways and its microbiota. The effect of certain microbial metabolites on the work of key enzymes involved in the biotransformation of amino acids and other substances becomes more important in patients at risk of developing neurological and mental disorders and also contributes to the development of life-threatening conditions up to multiple organ failure after operations, injuries, and serious diseases. The authors of this chapter call the microbiota an "invisible organ," emphasizing its functional significance, and not just taxonomy, as previously thought. This chapter will discuss the mutually beneficial integration of the metabolome/microbiome in the body of healthy people and will focus on the effects of microbiota dysfunction.

show abstract

“…Studies from animals and humans have indicated that there is a marked difference in the gut microbiota between obese and lean subjects, and the microbiota in the obese may further manipulate host metabolism leading to enhanced adiposity, inflammatory response, oxidative stress, and metabolic dysfunction . Xu et al also indicated that melatonin improves the richness and diversity of gut microbiota and reverses 14 operational taxonomic units (OTUs) in HF diet‐fed mice, especially for the ratio of Firmicutes to Bacteroidetes .…”

Section: Introductionmentioning

confidence: 99%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

Self Cite

331

277

View full text Add to dashboard Cite

Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.

show abstract

Gut Microbiota and Type 1 Diabetes

Cited by 164 publications

References 84 publications

Mycobiome in the Gut: A Multiperspective Review

Mycobiome in the Gut: A Multiperspective Review

Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Contact Info

Product

Resources

About