Gut microbiota and type 2 diabetes mellitus

Muñoz‐Garach, Araceli; Diaz-Perdigones, Cristina; Tinahones, Francisco J.

doi:10.1016/j.endoen.2016.07.004

Cited by 70 publications

(52 citation statements)

References 81 publications

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“…Studies illustrated that intestinal flora imbalance influences the development of type 2 diabetes by causing metabolic disorders such as insulin resistance. [8][9][10] On this basis, scholars found that promoting the growth of bifidobacteria and lactobacilli via probiotic supplementation, intestinal flora transplantation, or other means can reduce insulin resistance. 11,12 However, the mechanism by which intestinal flora disorder affects the initiation and progression of peripheral neuropathy related to type 2 diabetes requires further research for clarification.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

Wang

Ding

et al. 2020

J Int Med Res

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Objective To study the characteristics of the intestinal flora in patients with diabetic peripheral neuropathy (DPN) and analyze the association between the intestinal flora and clinical indicators. Methods We classified 80 subjects into three groups: patients with DPN (n = 45), patients type 2 diabetes without DPN (n = 21), and healthy controls (n = 14). The intestinal flora composition was compared among the three groups, and the correlation between the intestinal flora and clinical indicators was analyzed. Results At the phylum level, the richness of Firmicutes and Actinobacteria was elevated in the DN group, and that of Bacteroidetes was decreased. At the genus level, the richness of Bacteroides and Faecalibacterium was significantly decreased in the DPN group, whereas that of Escherichia- Shigella, Lachnoclostridium, Blautia, Megasphaera, and Ruminococcus torques group was increased. The homeostasis model assessment insulin resistance index was positively correlated with Megasphaera richness. Glycine ursodeoxycholic acid was positively correlated with Ruminococcus gnavus group and Phascolarctobacterium richness. Tauroursodeoxycholic acid was positively correlated with Ruminococcus gnavus group and Parabacteroides richness. Conclusion There was obvious intestinal microbiota disorder in patients with DPN, which may be related to insulin resistance. These changes may have important roles in the development of DPN.

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Section: Introductionmentioning

confidence: 99%

Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

Wang

Ding

et al. 2020

J Int Med Res

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“…The mechanisms of relating altered microbiota in producing insulin resistance, gut permeability, endotoxemia and effect on bile acids action, and brown adipose tissue proportion has been remarked. New approach to minimize the consequence the harmful effect by an attempt that reverses the mechanism of insulin resistance, T2D and obesity have been appreciated through the use of pro and prebiotics, transplant of appropriate gut microbiota and intake of suitable antibiotic therapy [42]. Obesity-associated disorders are the most common health concern which develops due to misbalance in food intake and energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

“…This study had given clue to the development of T1D in children [41,42]. In this regard, an approach to find the category of microbes in diabetic gut that are common in all cases are required to target for its treatment (Fig.…”

Section: Reason Iii: Diabetes Specific Gut Microbiotamentioning

confidence: 99%

Gut Microbiota and Diabetes Mellitus - An Interlinkage

Vijayasimha

Prabhakar

2018

Asian J Pharm Clin Res

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In recent years, the curiosity to investigate the relationship between gut microbiota and diabetes development has increased. Evidence from previous studies suggests that gut microbiota manipulation may assure to prevent diabetes development in future, primarily in susceptible individuals. Here, we reviewed special gut microbiota types proposing development of Type 1 (T1D) and Type 2 diabetes (T2D) in humans and laboratory animals. The available data we found are still inconclusive and required more attention in discriminating specific groups of gut microbiomes strongly indicating T1D and T2D development or prevention. Further, we suggested for the first time to study the gut microbiota in different ways to find the root cause of diabetes development.

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“…Interestingly, the use of three or more cups of coffee a day protects against NAFLD and the formation of fibrosis, possibly through an increase in autophagia of lipid droplets within hepatocytes (75). However, not only caloric intake, but also dietary composition has shown to play a role through dysbiosis of the gut microbiota, which most likely contributes to the development of NAFLD and NASH (27,76,77,78,79). A diet rich in lipids, animal-derived proteins and sugars provides a more favourable culture medium for certain bacterial species (like Bacteroides) than for others (80,81).…”

Section: Lifestyle and Nutritional Interventionsmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Non-alcoholic fatty liver disease: a multidisciplinary approach towards a cardiometabolic liver disease

Ruissen

Mak

Beuers³

et al. 2020

European Journal of Endocrinology

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Non-alcoholic fatty liver disease (NAFLD) is a growing health problem with a global prevalence of over 25% and prevalence rates of over 60% in high risk populations. It is considered the hepatic component of the metabolic syndrome and is associated with an increased risk of the development of various liver-associated and cardiometabolic complications. Given the complexity of NAFLD and associated comorbidities and complications, treatment requires interventions from a variety of different healthcare specialties. However, many clinicians are currently insufficiently aware of the potential harm and severity of NAFLD and associated comorbidities, complications and the steps that should be taken when NAFLD is suspected. Recognizing which patients suffer from non-progressive simple steatosis, metabolically active NASH with high risk of developing cardiovascular disease and which patients have a high risk of developing cirrhosis and hepatocellular carcinoma is important. Unfortunately, this can be difficult and guidelines towards the optimal diagnostic and therapeutic approach are ambivalent. Here we review the pathogenesis, diagnostics and treatment of NAFLD and discuss how multidisciplinary care path development could move forward.

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Gut microbiota and type 2 diabetes mellitus

Cited by 70 publications

References 81 publications

Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

Characteristics of the intestinal flora in patients with peripheral neuropathy associated with type 2 diabetes

Gut Microbiota and Diabetes Mellitus - An Interlinkage

MANAGEMENT OF ENDOCRINE DISEASE: Non-alcoholic fatty liver disease: a multidisciplinary approach towards a cardiometabolic liver disease

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