Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases

Kashtanova, Daria A.; Ткачева, О. Н.; Popenko, Anna; Egshatyan, Lilit; Tyakht, Alexander; Alexeev, Dmitry; Kotovskaya, Yu. V.; Plokhova, E V; Boytsov, S. А.

doi:10.1016/j.artres.2017.02.007

Cited by 12 publications

(9 citation statements)

References 20 publications

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“…On average, our participants had an overall Shannon Index value of 4.13. While some previously reported values are between about 2 to 3.7 [56,57], others are more akin to our own observation, with values between 4 to 5 [58,59]. One study reporting an average Shannon Index of 4.63 in participants, which is similar to our own results, considered that value to be high [58].…”

Section: Discussionsupporting

confidence: 87%

Associations between Frequency of Culinary Herb Use and Gut Microbiota

et al. 2022

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While evidence suggests that culinary herbs have the potential to modulate gut microbiota, much of the current research investigating the interactions between diet and the human gut microbiome either largely excludes culinary herbs or does not assess use in standard culinary settings. As such, the primary objective of this study was to evaluate how the frequency of culinary herb use is related to microbiome diversity and the abundance of certain taxa, measured at the phylum level. In this secondary data analysis of the INCLD Health cohort, we examined survey responses assessing frequency of culinary herb use and microbiome analysis of collected stool samples. We did not observe any associations between frequency of culinary herb use and Shannon Index, a measure of alpha diversity. Regarding the abundance of certain taxa, the frequency of use of polyphenol-rich herbs and herbs with certain quantities of antibacterial compounds was positively associated with Firmicutes abundance, and negatively associated with Proteobacteria abundance. Additionally, the total number of herbs used with high frequency, defined as over three times per week, was also positively associated with Firmicutes abundance, independent of adjustments, and negatively associated with Proteobacteria abundance, after adjusting for dietary factors. Frequency of culinary herb use was not associated with Bacteroidota or Actinobacteria abundance.

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Section: Discussionsupporting

confidence: 87%

Associations between Frequency of Culinary Herb Use and Gut Microbiota

et al. 2022

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“…It has been shown that the gut microbiome composition is associated with both atherosclerosis and arterial stiffness markers [ 23 ], and this may be potentially due to the bioactive metabolites derived from commensal organisms [ 24 ]. In a metabolomic study of specific indole and phenyl-derived metabolites originating solely or partly from gut microbes, it was concluded that specific microbe-derived metabolic signatures are associated with advanced human atherosclerosis and postoperative cardiac complications.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Revisit gut microbiota and its impact on human health and disease

Ding

Goh

et al. 2019

Journal of Food and Drug Analysis

219

123

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Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, diabetes, cancer, Inflammatory Bowel Disease (IBD), gout, depression and arthritis, as well as infant health and longevity.

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“…Besides TMAO, other gut microbiota-derived metabolites (incl. indoxyl sulfate [ 80 , 81 ], P -cresyl sulfate [ 82 ], phenylacetylglutamine [ 83 ], and equol [ 84 ]), as well as the composition of the gut microbiota [ 85 , 86 , 87 ] have been associated with AS.…”

Section: ‘Arteriometabolomics’ Approachmentioning

confidence: 99%

Metabolomics of Arterial Stiffness

Paapstel

Kals

2022

Metabolites

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Arterial stiffness (AS) is one of the earliest detectable signs of structural and functional alterations of the vessel wall and an independent predictor of cardiovascular events and death. The emerging field of metabolomics can be utilized to detect a wide spectrum of intermediates and products of metabolism in body fluids that can be involved in the pathogenesis of AS. Research over the past decade has reinforced this idea by linking AS to circulating acylcarnitines, glycerophospholipids, sphingolipids, and amino acids, among other metabolite species. Some of these metabolites influence AS through traditional cardiovascular risk factors (e.g., high blood pressure, high blood cholesterol, diabetes, smoking), while others seem to act independently through both known and unknown pathophysiological mechanisms. We propose the term ‘arteriometabolomics’ to indicate the research that applies metabolomics methods to study AS. The ‘arteriometabolomics’ approach has the potential to allow more personalized cardiovascular risk stratification, disease monitoring, and treatment selection. One of its major goals is to uncover the causal metabolic pathways of AS. Such pathways could represent valuable treatment targets in vascular ageing.

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Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases

Cited by 12 publications

References 20 publications

Associations between Frequency of Culinary Herb Use and Gut Microbiota

Associations between Frequency of Culinary Herb Use and Gut Microbiota

Revisit gut microbiota and its impact on human health and disease

Metabolomics of Arterial Stiffness

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