Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

Slyepchenko, Anastasiya; Maes, Michaël; Jacka, Felice N.; Köhler, Cristiano A.; Barichello, Tatiana; McIntyre, Roger S.; Berk, Michael; Grande, Iría; Foster, Jane A.; Vieta, Eduard; Carvalho, André F.

doi:10.1159/000448957

Cited by 220 publications

(158 citation statements)

References 194 publications

(221 reference statements)

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“…Therapeutic strategies for altering the gut microbiome include changes in diet, probiotics, and prebiotics. In this line, probiotics are being tested as procognitive agents in other psychiatric conditions given their antiinflammatory properties (Slyepchenko et al, 2017), so they appear as a new potential treatment to examine in bipolar illness.…”

Section: Future Clinical Directionsmentioning

confidence: 99%

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

Solé

Jiménez

Torrent³

et al. 2017

International Journal of Neuropsychopharmacology

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215

138

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Over the last decade, there has been a growing appreciation of the importance of identifying and treating cognitive impairment associated with bipolar disorder, since it persists in remission periods. Evidence indicates that neurocognitive dysfunction may significantly influence patients’ psychosocial outcomes. An ever-increasing body of research seeks to achieve a better understanding of potential moderators contributing to cognitive impairment in bipolar disorder in order to develop prevention strategies and effective treatments. This review provides an overview of the available data from studies examining treatments for cognitive dysfunction in bipolar disorder as well as potential novel treatments, from both pharmacological and psychological perspectives. All these data encourage the development of further studies to find effective strategies to prevent and treat cognitive impairment associated with bipolar disorder. These efforts may ultimately lead to an improvement of psychosocial functioning in these patients.

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Section: Future Clinical Directionsmentioning

confidence: 99%

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

Solé

Jiménez

Torrent³

et al. 2017

International Journal of Neuropsychopharmacology

Self Cite

215

138

View full text Add to dashboard Cite

show abstract

“…increased permeability), endogenous LPS can "leak" across defective tight junctions of the intestines into the body's circulation, which results in an immune response that can spur neuroinflammation and neuropsychiatric illness 72  LPS can disturb previously primed microglia to exacerbate neuroinflammation and prompt disease 56  Serum LPS levels emanating from damaged intestinal walls found to correlate with disease severity for neurodegenerative disorders in human patients (e.g., Parkinson's)…”

Section: Box 1: Key Points Related To Lipopolysaccharide (Lps)mentioning

confidence: 99%

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Sundman

Chen

Subbian

et al. 2017

Brain, Behavior, and Immunity

155

103

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The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease. AbstractAs head injuries and their sequelae have become an increasingly salient matter of public health, experts in the field have made great progress elucidating the biological processes occurring within the brain at the moment of injury and throughout the recovery thereafter. Given the extraordinary rate at which our collective knowledge of neurotrauma has grown, new insights may be revealed by examining the existing literature across disciplines with a new perspective. This article will aim to expand the scope of this rapidly evolving field of research beyond the confines of the central nervous system (CNS). Specifically, we will examine the extent to which the bidirectional influence of the gut-brain axis modulates the complex biological processes occurring at the time of traumatic brain injury (TBI) and over the days, months, and years that follow. In addition to local enteric signals originating in the gut, it is well accepted that gastrointestinal (GI) physiology is highly regulated by innervation from the CNS. Conversely, emerging data suggests that the function and health of the CNS is modulated by the interaction between 1) neurotransmitters, immune signaling, hormones, and neuropeptides produced in the gut, 2) the composition of the gut microbiota, and 3) integrity of the intestinal wall serving as a barrier to the external environment. Specific to TBI, existing pre-clinical data indicates that head injuries can cause structural and functional damage to the GI tract, but research directly investigating the neuronal consequences of this intestinal damage is lacking. Despite this void, the proposed mechanisms emanating from a damaged gut are closely implicated in the inflammatory processes known to promote neuropathology in the brain following TBI, which suggests the gut-brain axis may be a therapeutic target to reduce the risk of Chronic Traumatic Encephalopathy and other neurodegenerative diseases following TBI. To better appreciate how various peripheral influences are implicated in the health of the CNS following TBI, this paper will also review the secondary biological injury mechanisms and the dynamic pathophysiological response to neurotrauma. Together, this review article will attempt to connect the dots to reveal novel insights into the bidirectional influence of the gut-brain axis and propose a conceptual model relevant to the recovery from TBI and subsequent risk for future neurological conditions.

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“…Others studies demonstrated that the microorganisms from the phylum Firmicutes are increased and there is a great decrease in bifidobacteria [40][41][42]. Weight changes of NC, OC groups and mice given with the different dietary supplements OM, OY and OPY were determined weekly during 60 days.…”

Section: Resultsmentioning

confidence: 99%

Effect of Yogurt With or Without Probiotic Addition on Body Composition Changes and Immune System in an Obese Model

Maldonado-Galdeano¹

2017

FSN

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Yogurt is a dairy product made by milk fermented with Lactobacillus bulgaricus and Streptococcus thermophilus. Probiotic bacteria are added to conventional yogurt in order to boost benefits on the consumer health.In present work we studied in an obese mouse model the effect of the yogurt or probiotic yogurt supplementation to the diet on body weight, in biochemical parameters and in the thymus and intestinal immune system improvement. Adult mice received conventional balanced diet or a high-fat diet supplemented with milk, conventional yogurt or probiotic yogurt over 60 d. The body weight and biochemical parameters in serum (glucose, total LDL and HDL-cholesterol and triglycerides) were determined. Small intestine and thymus histology were analyzed. The changes in the gut microbiota, the possible translocation to internal organs and the levels of IgA and cytokines were also investigated. Probiotic yogurt was the most effective supplement for decreasing body weight and normalizing biochemical parameters in serum and in the improvement of small intestine and thymus histology. The gut microbiota showed increased bifidobacteria and recovered the balance of Enterobacteria population in obese mice given probiotic yogurt without translocation to internal organs, showing increases in IgA+ cells and cytokine production in gut. The present study demonstrated the safety and useful of yogurt consumption in obese host, benefiting mainly the innate mucosal immunity, biochemical parameters, intestine and thymus histology. These results allows advance in the research about the influence of functional foods on the thymus cells activity, which play a key role in the immune response.

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Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities

Cited by 220 publications

References 194 publications

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Effect of Yogurt With or Without Probiotic Addition on Body Composition Changes and Immune System in an Obese Model

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