Gut-microbiota derived bioactive metabolites and their functions in host physiology

Debnath, Nabendu; Kumar, Ravinder; Kumar, Ashwani; Mehta, Praveen Kumar; Yadav, Ashok Kumar

doi:10.1080/02648725.2021.1989847

Cited by 33 publications

(11 citation statements)

References 300 publications

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“…Host- or microbiota-mediated metabolic changes have been proven to play a central role in the development and outcomes of infectious diseases 3 , 9 , 37 . We then performed untargeted metabolomics to identify potential metabolites that affected the susceptibility of pathogen-induced mastitis.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

Zhao

Hao

et al. 2023

npj Biofilms Microbiomes

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Although emerging evidence shows that gut microbiota-mediated metabolic changes regulate intestinal pathogen invasions, little is known about whether and how gut microbiota-mediated metabolites affect pathogen infection in the distal organs. In this study, untargeted metabolomics was performed to identify the metabolic changes in a subacute ruminal acidosis (SARA)-associated mastitis model, a mastitis model with increased susceptibility to Staphylococcus aureus (S. aureus). The results showed that cows with SARA had reduced cholic acid (CA) and deoxycholic acid (DCA) levels compared to healthy cows. Treatment of mice with DCA, but not CA, alleviated S. aureus-induced mastitis by improving inflammation and the blood-milk barrier integrity in mice. DCA inhibited the activation of NF-κB and NLRP3 signatures caused by S. aureus in the mouse mammary epithelial cells, which was involved in the activation of TGR5. DCA-mediated TGR5 activation inhibited the NF-κB and NLRP3 pathways and mastitis caused by S. aureus via activating cAMP and PKA. Moreover, gut-dysbiotic mice had impaired TGR5 activation and aggravated S. aureus-induced mastitis, while restoring TGR5 activation by spore-forming bacteria reversed these changes. Furthermore, supplementation of mice with secondary bile acids producer Clostridium scindens also activated TGR5 and alleviated S. aureus-induced mastitis in mice. These results suggest that impaired secondary bile acid production by gut dysbiosis facilitates the development of S. aureus-induced mastitis and highlight a potential strategy for the intervention of distal infection by regulating gut microbial metabolism.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

Zhao

Hao

et al. 2023

npj Biofilms Microbiomes

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“…The tight interaction between the microbiome and immune function is also due to several microbial metabolites, which have their major receptors in the immune system. Many of them act as signals for different cells and contribute to the hormone secretion as well as to the regulation of metabolism and the host's immune system (Debnath et al, 2021). The gut microbiota can metabolize a broad spectrum of nutrients such as proteins, lipids, carbohydrates, bile acids, plant-derived molecules, and contaminants.…”

Section: Microbiome and Immune Function: A Mutual Regulationmentioning

confidence: 99%

Gut Microbiome in Retina Health: The Crucial Role of the Gut-Retina Axis

Scuderi

Troiani²,

Minnella

2022

Front. Microbiol.

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The term microbiome means not only a complex ecosystem of microbial species that colonize our body but also their genome and the surrounding environment in which they live. Recent studies support the existence of a gut-retina axis involved in the pathogenesis of several chronic progressive ocular diseases, including age-related macular disorders. This review aims to underline the importance of the gut microbiome in relation to ocular health. After briefly introducing the characteristics of the gut microbiome in terms of composition and functions, the role of gut microbiome dysbiosis, in the development or progression of retinal diseases, is highlighted, focusing on the relationship between gut microbiome composition and retinal health based on the recently investigated gut-retina axis.

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“…It should be noted that the colonization of the gastrointestinal tract by gut microbiota is associated with production by no specific metabolites. These substances also support the breakdown of undigested food, are substrates for numerous biochemical pathways, and thus indirectly fulfill the functions of regulatory in the gastrointestinal tract ( Debnath, Kumar, Kumar, Mehta, & Yadav, 2021 ). The key metabolites of gut microbiota include SCFAs, bile acids (BAs), amino acid, tryptamine and serotonin ( Ghosh, Shanahan, & O'Toole, 2022 ).…”

Section: Mechanisms Of the Regulatory Effects Of Marine Polysaccharid...mentioning

confidence: 99%

Regulatory effects of marine polysaccharides on gut microbiota dysbiosis: A review

Wang

Liu

et al. 2022

Food Chemistry: X

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Gut-microbiota derived bioactive metabolites and their functions in host physiology

Cited by 33 publications

References 300 publications

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice

Gut Microbiome in Retina Health: The Crucial Role of the Gut-Retina Axis

Regulatory effects of marine polysaccharides on gut microbiota dysbiosis: A review

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