Regulatory effects of marine polysaccharides on gut microbiota dysbiosis: A review

Ou, Jieying; Wang, Zhuo; Liu, Xiaofei; Song, Bingbing; Chen, Jianping; Li, Rui; Jia, Xuejing; Huang, Riming; Xiang, Wenzhou; Zhong, Saiyi

doi:10.1016/j.fochx.2022.100444

Cited by 17 publications

(8 citation statements)

References 118 publications

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“…The human intestinal microbiome is a diverse and complex ecosystem and is home to thousands of microorganisms that co-evolve with their hosts and play important roles in health and disease. The important role of intestinal microbial in health and disease has become a research focus ( 28 – 31 ). Intestinal microbial diversity is tightly associated with levels of estrogen and its metabolites ( 32 – 34 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Ping

Wang

et al. 2023

Front. Endocrinol.

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BackgroundIn recent years, mammary gland hyperplasia (MGH) has been considered to be one of the diseases caused by endocrine disorders. It has been shown that diseases caused by endocrine disorders can be treated by regulating intestinal microbial. As a commonly used medicine in clinical practice, Atractylodes Macrocephala Rhizoma has good functions in regulating intestinal homeostasis. Therefore, this paper studied the effect of Atractylodes Macrocephala Rhizoma polysaccharide (AMP) on the intestinal flora of MGH rats, providing a new idea for polysaccharide treatment of MGH.Materials and methodsEighteen female SD rats were selected and randomly divided into three groups: blank control group (Con), model control group (Mod), and AMP group, six rats in each group. MGH rat models were established by estradiol-progesterone combination and treated with AMP gastric infusion. The levels of E2, P, and PRL in the serum of rats were measured, the intestinal contents were collected, and 16s rRNA high- throughput sequencing technology was analyzed the changes of intestinal flora in the MGH rats.ResultsAMP has good therapeutic effects on MGH rats, decreasing estradiol (E2) and prolactin (PRL) levels and increasing progesterone (P) levels; at the same time, it can regulate the abundance and diversity of intestinal flora of MGH rats, improve the disorder of intestinal flora caused by MGH, and change the community structure, increase the abundance of beneficial flora, and decrease the abundance of pathogenic flora.ConclusionAMP can improve the intestinal microbiological environment of MGH rats, maintain the microecological balance of intestinal microbial, and improve MGH symptoms.

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Section: Discussionmentioning

confidence: 99%

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Ping

Wang

et al. 2023

Front. Endocrinol.

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“…Prebiotic activity can be shown by selectively stimulating the activity or increasing the relative abundance of beneficial bacteria and the production of beneficial metabolites such as SCFAs (Ou et al, 2022;Yao, Gong, et al, 2022) Han et al, 2017). The abundance ratio of the Bacteroidetes and Firmicutes is a significant indicator to estimate dysbacteriosis, which consequently usually evaluates the overall homeostasis of gut microbiota.…”

Section: Bsp and Gut Microbiotamentioning

confidence: 99%

“…Prebiotic activity can be shown by selectively stimulating the activity or increasing the relative abundance of beneficial bacteria and the production of beneficial metabolites such as SCFAs (Ou et al., 2022; Yao, Gong, et al., 2022). In vitro fecal fermentation is one of the most common methods for investigating prebiotic activity.…”

Section: Effects Of Bsp On the Intestinal Barriermentioning

confidence: 99%

Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

et al. 2023

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The intestinal barrier is critical in maintaining gut homeostasis and host health. The intestinal barrier dysfunction contributes to intestinal and systemic diseases like inflammatory bowel disease, colorectal cancer, and metabolic syndromes. This review summarizes the physicochemical properties of three main kinds of brown seaweed polysaccharides (BSP), laminarin, fucoidan, and alginate, along with their absorption and metabolism in the intestine and their effects on the intestinal barrier. The physicochemical properties of BSP were closely related to their beneficial effects on intestinal health. BSP were not digested directly in the upper gastrointestinal tract but could be utilized through fermentation by the gut microbiota. BSP kept the integrity of intestinal epithelium by ameliorating intestinal oxidative stress through the nuclear factor erythroid 2‐related factor 2 signaling pathway. They also reduced tight junction dysfunction and intestinal permeability and increased the expression of mucins. Moreover, BSP regulated the composition and abundance of gut microbiota and promoted the production of beneficial metabolites such as short‐chain fatty acids. This review will help to understand the gut health‐promoting functions of the natural compounds derived from brown seaweed and offer a new perspective on intestinal disease prevention and therapy with high effectiveness and safety.

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“…Meanwhile, a great deal of investigations have revealed that natural polysaccharides can modulate the gut microbiota composition and produce beneficial chemicals called short-chain fatty acids (SCFAs), thereby improving the health of the host. 19,20 In particular, dietary polysaccharides have been frequently documented to improve obesity, hyperlipidemia, and gut diseases triggered by HFD through modulating gut microbiota. 9,21,22 For instance, Guo et al investigated the anti-obesity activities of Chlorella pyrenoidosa polysaccharide (CPS) and Spirulina platensis polysaccharide (SPS) in HFD-treated C57BL/6 mice via using β-glucan as a standard.…”

Section: Introductionmentioning

confidence: 99%

The anti-hyperlipidemic effect and underlying mechanisms of barley (Hordeum vulgareL.) grass polysaccharides in mice induced by a high-fat diet

Yan,

Chen,

et al. 2023

Food Funct.

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Regulatory effects of marine polysaccharides on gut microbiota dysbiosis: A review

Cited by 17 publications

References 118 publications

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

The anti-hyperlipidemic effect and underlying mechanisms of barley (Hordeum vulgareL.) grass polysaccharides in mice induced by a high-fat diet

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