Gut Microbiota Dysbiosis and Altered Bile Acid Catabolism Lead to Metabolic Disorder in Psoriasis Mice

Abstract

Patients with psoriasis tend to have significant comorbidities, such as hyperlipemia, diabetes mellitus, and obesity, which belong to metabolic disorders. The specific mechanism through which psoriasis increases the metabolic disorder risk is uncertain. In this study, we demonstrated that the dysbiotic gut microbiota of 6-month-old psoriasis-like model mice (K14-VEGF-A-transgenic) exacerbated psoriasis disease and induced metabolic disorder when transferred into 2-month-old mice. By 16S rRNA gene sequencing, we confirmed that the Parabacteroides distasonis decreased with age in K14-VEGF mice, and P. distasonis also decreased in the transferred mice. Metabolomic screening identified an altered bile acid profile, including a decrease in chenodeoxycholic acid (CDCA) in the feces of transferred mice. Additionally, CDCA supplements prevented metabolic disorders in K14-VEGF-A-transgenic mice. Consequently, we found that aberrant bile acid metabolism may contribute to metabolic disorder in K14-VEGF-A-transgenic mice, indicating the possibility to prevent and treat the metabolic disorder in psoriasis mice by targeting gut microbial metabolites.

A Novel E3 Probiotics Formula Restored Gut Dysbiosis and Remodelled Gut Microbial Network and Microbiome Dysbiosis Index (MDI) in Southern Chinese Adult Psoriasis Patients

“…On the other hand, Parabacteroides distasonis , which increased occurrence in the control, was another potential key player of psoriasis. This observation was also recapitulated by other groups previously in the mice model and a population other than southern Chinese [ 31 , 60 , 61 , 62 ]. It has been reported to possess anti-inflammatory properties, with emerging in vitro and in vivo evidence to alleviate colonic inflammation [ 63 , 64 , 65 , 66 ].…”

Developing Strategies to Help Bee Colony Resilience in Changing Environments

“…Understanding bee health comprises studying and combining genetics, nutrition, microbiology, animal and plant biology (insects as individual and social organization), environmental science, agronomy, toxicology, biochemistry, beekeeping techniques, etc. ( Figure 1 ) [ 1 , 11 , 12 , 105 , 132 , 134 , 135 ]. Groups of researchers are emphasizing and supporting a collaboration between scientists, beekeepers, and farmers for future field experiments to allow for a better understanding of the complex biotic, abiotic, and social matrices shaping the health and disease of colonies [ 1 , 14 , 39 , 132 ].…”

Weizmannia coagulans: an Ideal Probiotic for Gut Health

“…have been recently found to possess a considerable number and diversity of bile salt hydrolase (BSH) [81]. Microbial BSHs in the gut play an important role in the metabolism of bile acids, which is associated with obesity, type-2 diabetes (T2D), and cardiovascular diseases [82]. Several W. coagulans strains have been reported to produce a wealth of digestive enzymes and employed to produce fermented foods, lactic acid, and various enzymes [31].…”

“…Research increasingly demonstrates the mutual interactions between gut microbiota and the metabolism system [82,88,89]. Gut microbiota-derived metabolites modulate intestinal endocrine cells producing gut hormones, including glucagon-like peptides (GLP), peptide YY (PYY), and gastric inhibitory polypeptide (GIP), which are involved in obesity and T2D [90,91].…”