Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms

Mendes de Almeida, Viviani; Engel, Daiane F.; Ricci, Mayra F.; Cruz, Clênio Silva; Lopes, Ícaro Santos; Alves, Daniele Almeida; d’ Auriol, Mirna; Magalhães, João; Machado, Elayne C.; Rocha, Victor M.; Carvalho, Toniana G.; Lacerda, Larisse S. B.; Pimenta, Jordane C.; Aganetti, Mariana; Zuccoli, Giuliana S.; Smith, Bradley J.; Carregari, Victor C.; da Silva Rosa, Erika; Galvão, Izabela; Dantas Cassali, Geovanni; Garcia, Cristiana C.; Teixeira, Mauro Martins; André, Leiliane C.; Ribeiro, Fabiola Mara; Martins, Flaviano S.; Saia, Rafael Simone; Costa, Vivian Vasconcelos; Martins-de-Souza, Daniel; Hansbro, Philip M.; Marques, João Trindade; Aguiar, Eric R. G. R.; Vieira, Angélica T.

doi:10.1080/19490976.2023.2249146

Cited by 23 publications

(15 citation statements)

References 82 publications

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“…In addition to dysregulated gene expression, several of these COVID-19-related proteins have also been found to interact with one or more SARS-CoV-2 viral proteins. Taken together, our results suggest that these HFDs, or the metabolic dysfunction and/or the dysbiosis caused by them, might be detrimental to COVID-19 patients 85 , 86 . While additional studies are required, it is nonetheless intriguing to speculate that effects of a high fat diet on the intestinal tract could potentially account for some of the demographics of the pandemic across different populations 87 , 88 …”

Section: Discussionmentioning

confidence: 63%

Impact of Various High Fat Diets on Gene Expression and the Microbiome Across the Mouse Intestines

Martinez-Lomeli,

Deol,

Deans

et al. 2023

Preprint

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High fat diets (HFDs) have been linked to several diseases including obesity, diabetes, fatty liver, inflammatory bowel disease (IBD) and colon cancer. In this study, we examined the impact on intestinal gene expression of three isocaloric HFDs that differed only in their fatty acid composition – coconut oil (saturated fats), conventional soybean oil (polyunsaturated fats) and a genetically modified soybean oil (monounsaturated fats). Four functionally distinct segments of the mouse intestinal tract were analyzed using RNA-seq – duodenum, jejunum, terminal ileum and proximal colon. We found considerable dysregulation of genes in multiple tissues with the different diets, including those encoding nuclear receptors and genes involved in xenobiotic and drug metabolism, epithelial barrier function, IBD and colon cancer as well as genes associated with the microbiome and COVID-19. Network analysis shows that genes involved in metabolism tend to be upregulated by the HFDs while genes related to the immune system are downregulated; neurotransmitter signaling was also dysregulated by the HFDs. Genomic sequencing also revealed a microbiome altered by the HFDs. This study highlights the potential impact of different HFDs on gut health with implications for the organism as a whole and will serve as a reference for gene expression along the length of the intestines.

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Section: Discussionmentioning

confidence: 63%

Impact of Various High Fat Diets on Gene Expression and the Microbiome Across the Mouse Intestines

Martinez-Lomeli,

Deol,

Deans

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Fecal transplantation from patients with COVID‐19 into germ‐free mice causes lung inflammation and cognitive impairment, indicating that the long‐term effects of the virus on intestinal flora directly mediate COVID‐19‐related symptoms and long COVID. 96 , 97 In addition, cohort studies on the association between gut microbiota and the severity of COVID‐19 symptoms have found that some gut microbiota are significantly associated with disease severity. Moreover, the abundance of actinobacteria can predict poor prognosis after infection, suggesting the feasibility of prediction models based on gut microbiota.…”

Section: Dynamic Changes Of Microbiota In Covid‐19mentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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“…For example, a notable prevalence of Veinollella was detected in COVID-19 patients experiencing respiratory dysfunction during the three-month follow-up [ 16 ]. Interestingly, an introduction of fecal material from post-COVID-19 individuals adversely influenced the lungs of recipient mice in the absence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contributing to a weakening of the host’s defense against bacterial infection [ 17 ]. Despite the evident link between long COVID-19 and dysbiosis, there is a limited number of original research articles addressing this topic.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome Composition and Dynamics in Hospitalized COVID-19 Patients and Patients with Post-Acute COVID-19 Syndrome

Brīvība,

Silamiķele,

Birzniece

et al. 2024

IJMS

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The gut microbiome plays a pivotal role in the modulation of host responses during viral infections, and recent studies have underscored its significance in the context of coronavirus disease 2019 (COVID-19). We aimed to investigate the dynamics and compositional changes in the gut microbiome of COVID-19 patients, addressing both the acute phase and the recovery process, with a particular focus on the emergence of post-COVID-19 conditions. Involving 146 COVID-19 patients and 110 healthy controls, this study employed a shotgun metagenomics approach for cross-sectional and longitudinal analyses with one- and three-month follow-ups. We observed a decline in taxonomic diversity among hospitalized COVID-19 patients compared to healthy controls, while a subsequent increase in alpha diversity was shown during the recovery process. A notable contribution of Enterococcus faecium was identified in the acute phase of the infection, accompanied by an increasing abundance of butyrate-producing bacteria (e.g., Roseburia, Lachnospiraceae_unclassified) during the recovery period. We highlighted a protective role of the Prevotella genus in the long-term recovery process and suggested a potential significance of population-specificity in the early gut microbiome markers of post-acute COVID-19 syndrome. Our study represents distinctive gut microbiome signatures in COVID-19, with potential diagnostic and prognostic implications, pinpointing potential modulators of the disease progression.

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Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms

Cited by 23 publications

References 82 publications

Impact of Various High Fat Diets on Gene Expression and the Microbiome Across the Mouse Intestines

Impact of Various High Fat Diets on Gene Expression and the Microbiome Across the Mouse Intestines

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Gut Microbiome Composition and Dynamics in Hospitalized COVID-19 Patients and Patients with Post-Acute COVID-19 Syndrome

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