Gut microbiota in chronic kidney disease

Guldrís, Secundino Cigarrán; Parra, Emilio González; Amenós, Aleix Cases

doi:10.1016/j.nefroe.2017.01.017

Cited by 66 publications

(105 citation statements)

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“…We may suppose that the gut dysbiosis could be attributed to a modification of key factor and mediator produced by the microorganisms (e.g., butyrate, H 2 S, ROS, NO), which might influence mitochondrial function related to energy production, redox balance and inflammatory processes, and subsequently muscle physiology [17]. Patients under dialysis differ from normal healthy population as previously observed by numerous studies in the literature [18,19]. Treatment, medication and accumulation of uraemic toxins in patients with CKD might contribute to changes of gut microbiota quality.…”

Section: Discussionmentioning

confidence: 90%

Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients using Citrate Dialysate: A Pilot Study

et al. 2018

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Background/Aims: Hemodialysis-associated muscle cramp (HAMC) is a common complication under citrate dialysate (CD) occurring in 30% of cases. Our objectives were to assess the gut microbiota quality, mitochondrial activity, and to investigate their possible relationship with HAMC. Methods: Ten end-stage renal disease patients (78.9 ± 2.1 years) treated by hemodialysis (HD) with CD were enrolled and then classified according to the frequency of HAMCs: “frequent HAMCs group” (n = 5) and “absence of HAMCs group” (n = 5). Gut microbiota quality, mitochondrial activity, and some markers of oxidative stress (OS) were investigated. Results: In patients with cramps, gut microbiota diversity seemed lower and some genera including Helicobacter, Lachnospira, Roseburia, and Haemophilus seemed over-expressed, a significant increase of citratemia and significant lowering mitochondrial function were observed. No difference was observed on the OS markers. Conclusion: This first clinical study revealed a possible dysbiosis of microbiota and a mitochondrial dysfunction into HD patients with cramps under CD compared to patients without cramp.

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Section: Discussionmentioning

confidence: 90%

Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients using Citrate Dialysate: A Pilot Study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

“…Recent reviews have emphasized the changes in the intestinal microbiome called dysbiosis that develops early in chronic kidney disease and contributes to an increase in intestinal mucosal permeability. 44,45 This is further aggravated by both the edema of the bowel wall and mesenteric ischemia. Increased intestinal permeability results in increased absorption of microbiome-derived uremic toxins such as indoxyl sulfate, which is associated with endothelial dysfunction and vascular calcification; 46 simultaneously, bacterial translocation and endotoxemia become highly prevalent, the latter being especially common after the initiation of dialysis and most prominent in hemodialysis patients with hemodynamic instability and myocardial stunning.…”

Section: Discussionmentioning

confidence: 99%

The association of overhydration with chronic inflammation in chronic maintenance hemodiafiltration patients

Zsom¹,

Faludi

Fülöp

et al. 2019

Hemodialysis International

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Introduction: Achieving euvolemia is one of the major challenges when treating end‐stage renal disease (ESRD) patients receiving maintenance renal replacement therapy. Fluid overload is recognized as an independent predictor of mortality in ESRD, but its association with chronic inflammation is less well explored especially in chronic maintenance hemodiafiltration. Methods: We performed a cross‐sectional study of 87 prevalent ESRD patients receiving chronic maintenance hemodiafiltration (vintage 66.5 ± 57.1 months) with bioimpedance analysis to characterize the degree of percent overhydration (OH%). We also compared the levels of inflammatory markers, including C‐reactive protein (CRP), serum albumin, neutrophil/lymphocyte ratio (NLR), and hemoglobin red cell distribution width (RDW) for the overhydrated (OH% ≥ 15%) versus euvolemic (OH% < 15%) groups. Linear regression analysis was performed to explore relationships between the degree of OH and inflammatory indicators. Findings: The cohort represented an all‐European population with a mean age of 60.9 ± 14.7 years and prevalence of diabetes mellitus of 27%. The entire cohort's OH% was 14.9% ± 5.1% (range −11.1% to 39.0%); further, the <15% group of patients’ OH% was 8.0% ± 8.5% versus 20.9% ± 5.1% in the OH% ≥ 15% group (P < 0.0001). Forty‐seven patients (53%) were overhydrated by traditional criteria (OH% ≥15%) and 20 patients (23%) were severely overhydrated (OH% > 20%). The euvolemic (OH% <15%) versus severely overhydrated (OH% > 20%) groups had significant differences in markers of inflammation: CRP (9.8 ± 10.6 vs. 21.5 ± 21.6 mg/L, P < 0.006), serum albumin (37.6 ± 02.9 vs. 34.5 ± 5.3 g/L, P < 0.004), and NLR (3.06 ± 1.25 vs. 3.92 ± 2.04; P < 0.004). On linear regression, significant correlations were found between OH% and CRP (r = 0.2899, P < 0.006), serum albumin (r = −0.3670; P < 0.0005), RDW (r = 0.2992; P < 0.005), and NLR (r = 0.2900; P < 0.006). Discussion: In a prevalent hemodiafiltration cohort, OH was common and correlated with several inflammatory markers.

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“…Now a days, there are an increasing number of evidences recorded, which state that due to dysbiosis there might be the progression of CKD and CKD-related problems [30,31]. It was found that due to gut dysbiosis, the concentrations of the endotoxins are increased due to the processes such as fermentation carried out by pathogenic bacteria in the gut region [32]. As a result of such activities, the products which are formed due to these activities like endotoxins such as phenols, indoles and amines cross the intestinal barrier, and then mix with the bloodstream [32].…”

Section: This Article Is Part Of the Topical Collection On Medicinementioning

confidence: 99%

Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective

Arun

Reddy

Akhter

2018

SN Compr. Clin. Med.

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In this work, we proposed a research hypothesis which mainly focuses on the role of gut microbiota, in relation with chronic kidney disease, existing in the village of Uddanam belonging to the State of Andhra Pradesh, India. Earlier studies conducted on various physical and chemical parameters, such as food, water, soil and pesticides, could not find the exact cause of the aetiology of the disease. As there were no physical and chemical causative factors identified, this disease was hence named as mysterious Uddanam kidney nephropathy of unknown origins. There are few scientific pieces of evidence available in the literature, which suggests the role of gut microbiome dysbiosis and its impact on kidney disease. Such kinds of scientific studies which deal with the analysis of microbial communities of the gut region and identification of dysbiosis were not performed in the case of Uddanam kidney nephropathy. Thus, through this paper, we propose a hypothesis to analyse and establish the relationship between the gut dysbiosis and renal failure by performing the metagenomics study between the patients and the normal individuals. To the best of our knowledge, there are no reports available to date on the dysbiosis of the gut microbiome and its impact on Uddanam nephropathy and hence this research hypothesis is thus proposed.

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Gut microbiota in chronic kidney disease

Cited by 66 publications

References 104 publications

Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients using Citrate Dialysate: A Pilot Study

Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients using Citrate Dialysate: A Pilot Study

The association of overhydration with chronic inflammation in chronic maintenance hemodiafiltration patients

Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective

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