Gut microbiota mediates the effects of curcumin on enhancing Ucp1-dependent thermogenesis and improving high-fat diet-induced obesity

Han, Zaiqi; Lü, Yan; Zhong, Yue; Xiao, Yang; Gao, Jing; Fan, Sijia; Zhang, Ziheng; Gong, Shanggang; Chang, Si‐Chung; Cui, Xiaona; Cai, Jianhui

doi:10.1039/d1fo00671a

Cited by 37 publications

(32 citation statements)

References 51 publications

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“…They are produced in the liver and biochemically modified by intestinal bacteria. BA can act as signaling molecules in many tissues and influence host metabolism through signaling pathways through BA detecting receptors [ 46 ]. Among them, BAs have been found to increase the activity of BAT via G protein-coupled bile acid receptor 5 (TGR5) [ 47 ].…”

Section: Reciprocal Interaction Between Curcumin and Gut Microbiota (Gm)mentioning

confidence: 99%

“…Han et al [ 46 ] investigated whether GM mediates the effects of curcumin in improving energy homeostasis. For this purpose, mice fed a high-fat diet (HFD) uncoupling protein 1 (Ucp1) knockout and G protein-coupled membrane receptor 5 (TGR5) were used.…”

Section: Reciprocal Interaction Between Curcumin and Gut Microbiota (Gm)mentioning

confidence: 99%

“…The administration of curcumin changed the metabolism of BA—the content of deoxycholic acid (DCA) and lithocholic acid (LCA) (the two strongest ligands for TGR5) increased. The study revealed that in order to activate the cAMP/PKA signaling pathway in thermogenic adipose tissue through curcumin, interaction of GM and TGR5 is needed [ 46 ].…”

Section: Reciprocal Interaction Between Curcumin and Gut Microbiota (Gm)mentioning

confidence: 99%

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Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

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Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there is a tendency to use natural compounds for the management of obesity. There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. Curcumin is a is an important compound present in Curcuma longa L. rhizome. It is a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as a pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. This plant metabolite doubtless effectiveness has been reported through increasingly detailed in vitro, in vivo and clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes have been remarkably highlighted. This review documents the status of research on anti-obesity mechanisms and evaluates the effectiveness of curcumin for management of obesity. It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota and anti-inflammatory potential of curcumin. However, there is still a need for systematic and targeted clinical studies before curcumin can be used as the mainstream therapy for managing obesity.

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Section: Reciprocal Interaction Between Curcumin and Gut Microbiota (Gm)mentioning

confidence: 99%

Section: Reciprocal Interaction Between Curcumin and Gut Microbiota (Gm)mentioning

confidence: 99%

Section: Reciprocal Interaction Between Curcumin and Gut Microbiota (Gm)mentioning

confidence: 99%

See 1 more Smart Citation

Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

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“…Studies have shown that Lactobacillus , a probiotic, can metabolise sugar into lactic acid and participate in the metabolism of Bile Acids (BA). Anaerotruncus produces butyric acid, which is associated with obesity ( 61 ). Roseburia produces SCFAs that are associated with obesity ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat Diet

Tian

Zhang

et al. 2022

Front. Nutr.

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Dietary supplementation with mung bean peptides (MBPs) has several health benefits. However, the effect of MBPs on prediabetes and gut microbiota imbalance caused by a high-fat diet (HFD) has not been thoroughly studied. In this study, dietary supplementation with MBPs for 5 weeks significantly reduced HFD-induced body weight gain, hyperglycaemia, hyperlipidaemia, insulin resistance, inflammation, and oxidative stress and alleviated liver and kidney damage in mice. In addition, it significantly reversed the HFD-induced gut microbiota imbalance, increased the gut microbial diversity, and decreased the abundance of Firmicutes and Bacteroidetes in prediabetic mice. Furthermore, we identified Lachnospiraceae_NK4A136 and Lactobacillus as important eubacteria with the potential to alleviate the clinical symptoms of prediabetes. According to PICRUSt2 analysis, the changes in intestinal microflora induced by MBPs diet intervention may be related to the downregulation of expression of genes such as rocR, lysX1, and grdA and regulation of seven pathways, including pyruvate, succinic acid, and butyric acid. Moreover, 17 genera with significantly altered levels in the intestine of HFD-fed mice, including Akkermansia, Roseburia, and Ruminiclostridium, were significantly correlated with 26 important differential metabolites, such as D-glutathione, anti-oleic acid, and cucurbitacin. Overall, these results show that MBPs diet intervention plays a key role in the management of HFD-induced prediabetes.

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“…On the other hand, Curcumin could affect intestinal microbiota to prevent renal failure [6]. Conversely, intestinal microbiota could also enhance the effect of Curcumin in ameliorating HFDinduced obesity by enhancing Ucp1-dependent thermogenesis through regulating bile acids metabolism [8], suggesting the interaction between intestinal microbiota and Curcumin in curing diseases.…”

Section: Introductionmentioning

confidence: 99%

Curcumin sensitizes response to cytarabine in acute myeloid leukemia by regulating intestinal microbiota

Liu

Luo

Chen

et al. 2022

Cancer Chemother Pharmacol

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Purpose To address whether Curcumin has synergistic effect with cytarabine (Ara-C) in treating acute myeloid leukemia (AML). Methods A xenograft AML mouse model was established by injecting HL-60 cells into tail vein of mice to assess the function of Curcumin. Mononuclear cells (MNCs) isolated from AML mice and AML cell lines were used to examine the effect of Curcumin. Metagenomics and metabolomics were used to evaluate the alteration of intestinal microbiota and the change of metabolites in MNCs. Results Curcumin treatment sensitized response to Ara-C in MNCs of AML mice, but had no direct effect on AML cell lines. Metagenomics revealed an alteration of intestinal microbiota with Curcumin treatment, which contributes to sensitized response to Ara-C. Curcumin treatment led to enhanced intestinal intact to sensitize response to Ara-C in AML mice, through reducing mucus degrading bacteria. Metabolomics demonstrated that Curcumin treatment led to decreased cholesterol in MNCs of AML mice. Further study proved that Curcumin treatment resulted in inhibition of SQLE, a key enzyme of cholesterol biosynthesis, to increase sensitivity to Ara-C. Conclusion Curcumin sensitizes response to Ara-C through regulating microbiota, highlighting the importance of intestinal intact strengthening in chemoresistant therapy. Moreover, aiming at cholesterol synthesis is promising in AML treatment.

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Gut microbiota mediates the effects of curcumin on enhancing Ucp1-dependent thermogenesis and improving high-fat diet-induced obesity

Abstract: Due to extremely poor systemic bioavailability, the mechanism by which curcumin increases energy expenditure remains unelucidated. Accumulating evidence suggests a strong association between the gut microbiota (GM) and energy metabolism....

Cited by 37 publications

References 51 publications

Curcumin and Weight Loss: Does It Work?

Curcumin and Weight Loss: Does It Work?

Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat Diet

Curcumin sensitizes response to cytarabine in acute myeloid leukemia by regulating intestinal microbiota

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