Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Fang, Zhifeng; Li, Lingzhi; Zhang, Hao; Zhao, Jianxin; Liu, Wenwei; Chen, Wei

doi:10.3389/fimmu.2021.720393

Cited by 105 publications

(97 citation statements)

References 145 publications

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“…Elevated fecal caproic acid levels suggest altered gut microbial communities in infants with allergic symptoms [ 26 , 27 ]. Experimental data [ 28 ] had showed that the intestinal bifidobacteria, gram-positive aerobic bacteria and enterococci were relatively few, but children with a high number of Clostridium and Staphylococcus aureus are prone to allergic symptoms.…”

Section: Resultsmentioning

confidence: 99%

“…Several review articles about probiotics and gut microbiota with AD were already published and should be considered. Fang et al [ 28 ] have focused on the the potential mechanisms of probiotics on alleviating AD via upregulation of epidermal barrier and regulation of immune signaling, and the possible effective substances on AD, which provide the supports for targeting gut microbiota to AD prevention and treatment. Disamantiaji et al [ 69 ] have included a total of 5 studies, and have concluded that probiotics supplementation in the management of eczema in children does not show a clinically relevant difference vs. standard treatment in reducing eczema severity.…”

Section: Discussionmentioning

confidence: 99%

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Gut microbiota and atopic dermatitis in children: a scoping review

Liu¹,

Zhai³

et al. 2022

BMC Pediatr

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Background Gut microbiota plays an important role in the development of atopic dermatitis (AD). We aimed to elucidate research trends in gut microbiota and AD in children, to provide evidence and insights to the clinical prevention and treatment of AD in children. Methods A scoping literature review on the studies of gut microbiota and AD were conducted. Two authors independently searched Pubmed et al. databases for studies focused on gut microbiota and AD in children up to January 15, 2022. The literatures were screened and analyzed by two reviewers. Results A total of 44 reports were finally included and analyzed. Current researches have indicated that abnormal human microecology is closely associated with AD, and the disturbance of intestinal microbiota plays an important role in the occurrence and development of AD. Probiotics can correct the microbiota disorder, have the functions of regulating immunity, antioxidant, and help to restore the microecological homeostasis. However, there is still a lack of high-quality research reports on the efficacy and safety of probiotics in the prevention and treatment of AD in children. Conclusions The changes of gut microbiota are essential to the development of AD in children, which may be an effective target for the prevention and treatment of AD. Future studies with larger sample size and rigorous design are needed to elucidate the effects and safety of probiotics in AD.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gut microbiota and atopic dermatitis in children: a scoping review

Liu¹,

Zhai³

et al. 2022

BMC Pediatr

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“…For children with ASD, Xu et al summarized that the relative abundance of Bifidobacterium was lower compared to controls (Xu et al, 2019). Even though several studies had revealed that Bifidobacterium was less in AD infants compared to healthy controls (Fang et al, 2021), controversy always exists. A cross-sectional study from Brazil revealed that AD children had a greater abundance of Bifidobacterium (OR: 11.09; 95% CI: 2.14; 57.39) (Melli et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis

Hong

Hou²,

Xu³

et al. 2022

Front. Cell. Infect. Microbiol.

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Autism is a kind of biologically based neurodevelopmental condition, and the coexistence of atopic dermatitis (AD) is not uncommon. Given that the gut microbiota plays an important role in the development of both diseases, we aimed to explore the differences of gut microbiota and their correlations with urinary organic acids between autistic children with and without AD. We enrolled 61 autistic children including 36 with AD and 25 without AD. The gut microbiota was sequenced by metagenomic shotgun sequencing, and the diversity, compositions, and functional pathways were analyzed further. Urinary organic acids were assayed by gas chromatography–mass spectrometry, and univariate/multivariate analyses were applied. Spearman correlation analysis was conducted to explore their relationships. In our study, AD individuals had more prominent gastrointestinal disorders. The alpha diversity of the gut microbiota was lower in the AD group. LEfSe analysis showed a higher abundance of Anaerostipes caccae, Eubacterium hallii, and Bifidobacterium bifidum in AD individuals, with Akkermansia muciniphila, Roseburia intestinalis, Haemophilus parainfluenzae, and Rothia mucilaginosa in controls. Meanwhile, functional profiles showed that the pathway of lipid metabolism had a higher proportion in the AD group, and the pathway of xenobiotics biodegradation was abundant in controls. Among urinary organic acids, adipic acid, 3-hydroxyglutaric acid, tartaric acid, homovanillic acid, 2-hydroxyphenylacetic acid, aconitic acid, and 2-hydroxyhippuric acid were richer in the AD group. However, only adipic acid remained significant in the multivariate analysis (OR = 1.513, 95% CI [1.042, 2.198], P = 0.030). In the correlation analysis, Roseburia intestinalis had a negative correlation with aconitic acid (r = -0.14, P = 0.02), and the latter was positively correlated with adipic acid (r = 0.41, P = 0.006). Besides, the pathway of xenobiotics biodegradation seems to inversely correlate with adipic acid (r = -0.42, P = 0.18). The gut microbiota plays an important role in the development of AD in autistic children, and more well-designed studies are warranted to explore the underlying mechanism.

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“…These topics included the microbiome and probiotics. The roles played by the microbiological environments of the skin and other organs (e.g., the gut) remain poorly understood, as do the effects of probiotics [ 9 ]. As patients are now increasingly exposed to commercial probiotics, any abnormal changes in the composition or functions of the AD microbiome require attention, as do any effect of probiotics on AD.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the clinical evaluation and management of AD remain challenging [ 8 ]. Recently developed drugs (dupilumab, oluminant, and rinvoq), a growing interest in patient quality of life, and new potential therapeutic targets (such as the gut and skin microbiomes [ 9 , 10 , 11 , 12 , 13 , 14 ]) have motivated researchers to intensify their current approaches and explore new areas of AD research.…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric Analysis of Atopic Dermatitis Research over the Past Three Decades and Future Perspectives

et al. 2021

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Atopic dermatitis (AD) has been increasing in prevalence over the past few decades; however, AD has never been analyzed using a bibliometric approach. We searched for AD studies in the dermatology and allergy category of the Web of Science and SCOPUS databases using the keywords “atopic dermatitis”, “eczema”, and “atopy”. In total, 53,460 documents were retrieved. We analyzed annual publication trends and performed keyword and co-authorship network analyses. The annual number of AD publications has increased over the years. Asthma, food allergies, the skin barrier, IgE, and epidemiology have received extensive attention. The keywords ‘allergic rhinitis’, ‘child(ren)’, ‘quality of life’, and ‘probiotics’ have become more commonly used in recent years. AD research has been led by only a few countries, such as the USA, Germany, and the UK, and longstanding research topics such as asthma, allergy, and the immune system continue to be important. We suggest that global collaborations, research in developing countries, and research that is more holistic (thus exploring how genes, the immune system, the environment, and the microbiome together impact AD) are necessary.

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Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review

Cited by 105 publications

References 145 publications

Gut microbiota and atopic dermatitis in children: a scoping review

Gut microbiota and atopic dermatitis in children: a scoping review

The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis

A Bibliometric Analysis of Atopic Dermatitis Research over the Past Three Decades and Future Perspectives

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