Gut microbiota and atopic dermatitis in children: a scoping review

Liu, Yue; Du, Xiaofan; Zhai, Shujie; Tang, Xiaodong; Liu, Cuiling; Li, Weihong

doi:10.1186/s12887-022-03390-3

Cited by 17 publications

(19 citation statements)

References 62 publications

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“…development of AD, because of the importance of gutassociated immunity in this condition (West et al 2015;Liu et al 2022). The oral microflora may play an important role in the development of allergies, because the oral cavity is the first part of the digestive tract that is supervised by immunity (Dzidic et al 2018;Cai et al 2022).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

Uchiyama

Osumi

Mizukami

et al. 2022

Letters in Applied Microbiology

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Atopic dermatitis (AD) is a chronic and relapsing multifactorial inflammatory skin disease that also affects dogs. The oral and gut microbiota are associated with many disorders, including allergy. Few studies have addressed the oral and gut microbiota in dogs, although the skin microbiota has been studied relatively well in these animals. Here, we studied the AD‐associated oral and gut microbiota in 16 healthy and 9 AD dogs from a purebred Shiba Inu colony. We found that the diversity of the oral microbiota was significantly different among the dogs, whereas no significant difference was observed in the gut microbiota. Moreover, a differential abundance analysis detected the Family_XIII_AD3011_group (Anaerovoracaceae) in the gut microbiota of AD dogs; however, no bacterial taxa were detected in the oral microbiota. Third, the comparison of the microbial co‐occurrence patterns between AD and healthy dogs identified differential networks in which the bacteria in the oral microbiota that were most strongly associated with AD were related to human periodontitis, whereas those in the gut microbiota were related to dysbiosis and gut inflammation. These results suggest that AD can alter the oral and gut microbiota in dogs.

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Section: Introductionmentioning

confidence: 99%

“…2015; Liu et al . 2022). The oral microflora may play an important role in the development of allergies, because the oral cavity is the first part of the digestive tract that is supervised by immunity (Dzidic et al .…”

Section: Introductionmentioning

confidence: 99%

Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

Uchiyama

Osumi

Mizukami

et al. 2022

Letters in Applied Microbiology

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“…On the genus level, MPRO administration led to elevated levels of Bifidobacterium , Lismosilactobacillus , and Lactobacillus ( Figure 5 D). Notably, previous studies have highlighted an elevated abundance of the Staphylococcus genus in AD patients, potentially contributing to AD pathophysiology [ 32 , 33 , 34 ]. In AD mice, Staphylococcus spp.…”

Section: Resultsmentioning

confidence: 99%

Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders

Lee,

Kim,

Verma

et al. 2024

Nutrients

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The composition and diversity of gut microbiota significantly influence the immune system and are linked to various diseases, including inflammatory and allergy disorders. While considerable research has focused on exploring single bacterial species or consortia, the optimal strategies for microbiota-based therapeutics remain underexplored. Specifically, the comparative effectiveness of bacterial consortia versus individual species warrants further investigation. In our study, we assessed the impact of the bacterial consortium MPRO, comprising Lactiplantibacillus plantarum HY7712, Bifidobacterium animalis ssp. lactis HY8002, and Lacticaseibacillus casei HY2782, in comparison to its individual components. The administration of MPRO demonstrated enhanced therapeutic efficacy in experimental models of atopic dermatitis and inflammatory colitis when compared to single strains. MPRO exhibited the ability to dampen inflammatory responses and alter the gut microbial landscape significantly. Notably, MPRO administration led to an increase in intestinal CD103+CD11b+ dendritic cells, promoting the induction of regulatory T cells and the robust suppression of inflammation in experimental disease settings. Our findings advocate the preference for bacterial consortia over single strains in the treatment of inflammatory disorders, carrying potential clinical relevance.

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“…In an observational clinical trial, a multi-strain probiotic was administered orally to pregnant women from 4 weeks before delivery to 4 weeks after delivery. The secretion of sIgA in the infant’s feces suggested that oral probiotics during pregnancy and delivery contribute to the improvement of intestinal barrier function during the neonatal period [ 24 ].…”

Section: The Role Of Exposome Components During Prenatal and Perinata...mentioning

confidence: 99%

The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

Grafanaki

Bania

Kaliatsi

et al. 2023

JCM

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Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects more than 200 million people worldwide, including up to 20% of children and 10% of the adult population. Although AD appears frequently in childhood and often continues into adulthood, about 1 in 4 adults develop the adult-onset disease. The prenatal period, early childhood, and adolescence are considered critical timepoints for the development of AD when the exposome results in long-lasting effects on the immune system. The exposome can be defined as the measure of all the exposures of an individual during their lifetime and how these exposures relate to well-being. While genetic factors could partially explain AD onset, multiple external environmental exposures (external exposome) in early life are implicated and are equally important for understanding AD manifestation. In this review, we describe the conceptual framework of the exposome and its relevance to AD from conception and across the lifespan. Through a spatiotemporal lens that focuses on the multi-level phenotyping of the environment, we highlight a framework that embraces the dynamic complex nature of exposome and recognizes the influence of additive and interactive environmental exposures. Moreover, we highlight the need to understand the developmental origins of AD from an age-related perspective when studying the effects of the exposome on AD, shifting the research paradigm away from the per se categorized exposome factors and beyond clinical contexts to explore the trajectory of age-related exposome risks and hence future preventive interventions.

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Gut microbiota and atopic dermatitis in children: a scoping review

Cited by 17 publications

References 62 publications

Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders

The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

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