Guttiferone BL with antibacterial activity from the fruits of Allanblackia gabonensis

Abstract

Allanblackia genus, an endless source of bioactive compounds, was investigated for its antibacterial properties. The chemical study of the methanol extract from the fruits of Allanblackia gabonensis resulted in the isolation of the undescribed guttiferone BL (1) along with the known kaempferol (2), morelloflavone (3), morelloflavone 7″-O-β-D-glucopyranoside (4), β-sitosterol 3-O-β-D-glucopyranoside and β-sitosterol. Their structures were determined using spectrometry and spectroscopic techniques. The antibacterial activity was evaluated against five Gram-negative and two Gram-positive strains using a broth micro-dilution method. Compounds displayed low to significant activity against the tested bacterial strains with MICs ranging from 8 to 512 μg/mL. Morelloflavone (3) presented significant activity against E. coli ATCC8739 (MIC = 8 μg/mL) while guttiferone BL (1) exhibited low activity (MICs = 256-512 μg/mL) against all the tested strains. The crude extract also had moderate to significant activity against the tested bacterial strains.

Anticancer Properties and Mechanism of Action of Oblongifolin C, Guttiferone K and Related Polyprenylated Acylphloroglucinols

“…There are 21 guttiferone derivatives (designated Gt-A to Gt-U) and many variants, such as oxy-Gt-K or K2, oxy-Gt-A, -I, -M, 2,16-oxy-Gt-A [ 18 ] and many others such as Gt-BL [ 19 ]. Similarly, there are about 30 oblongifolin derivatives (named Ob-A to Ob-Z, and Ob-AA and variants) inventoried in the PPAPs database.…”

“…Different pharmacological properties have been reported with oblongifolins and guttiferones, including modest antiviral effects observed with Ob-J and Ob-M [ 22 ] and antibacterial effects reported with different guttiferone derivatives, including Gt-A [ 19 , 49 ]. This latter compound exerts also antifungal [ 50 , 51 ] and antiparasite activities [ 30 , 52 , 53 ].…”

Toward the Allelopathy of Peganum sp. and Related Chemical Constituents in Agriculture

“…The context of the research in Africa in respect to the subject is discussed. This survey follows our continued search for the application of plant extracts and constituents as principal feedstocks in the development of drugs and allelochemicals (Koagne et al, 2017;Nganou et al, 2019b;Tchinda et al, 2019;Mbaveng et al, 2020;Ben Mrid et al, 2021;Damen et al, 2021). The core of pool documents examined for this review was provided from SciFinder-n and PubMed or ScienceDirect when entering the references "Peganum and activities" and refining the search with different concepts including fungicides, proteins, growth and development, plant, insecticides, lipid peroxidation, herbicides, phytopathogens, seedling, and phytotoxicity.…”

Sesquiterpene Lactones from Vernonia tufnelliae: Structural Characterization and Biological Evaluation

“…Compound 1 contains an unprecedented 10/5/5/6 tetracyclic moiety featuring a hexahydro-1 H ,3 H ,7 H -furo­[3′,4′:3,4]­furo­[3,2- c ]­pyridin-1-one unit linked to a typical cyclodecane ring of germacrene, while compound 2 is the first elemane–germacranolide heterodimer ever to have been found in Nature. The present report is part of an ongoing research initiative on bioactive metabolites from Cameroonian folk medicine. − …”

“…The known compounds 8α-[4′-hydroxymethacryloyloxy]sonchucarpolide (6), 42 onopordopicrin (7), 43 1H-indole-3carbaldehyde (8), 43 apigenin (9), pedalitin (10), 44 apigenin 7-O-β-glucopyranoside (11), apigenin 7-O-β-glucuronide ( 12), luteolin 7-O-β-glucuronide (13), 45 2,4′-methylenebisphenol (14), and bisphenol F (15) 46 were identified by comparison of their spectroscopic data with those reported in the literature.…”