2019
DOI: 10.1111/jcmm.14429
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Gutting the brain of inflammation: A key role of gut microbiome in human umbilical cord blood plasma therapy in Parkinson's disease model

Abstract: Current therapies for Parkinson's disease (PD), including L‐3,4‐dihydroxyphenylalanine (L‐DOPA), and clinical trials investigating dopaminergic cell transplants, have generated mixed results with the eventual induction of dyskinetic side effects. Although human umbilical cord blood (hUCB) stem/progenitor cells present with no or minimal capacity of differentiation into mature dopaminergic neurons, their transplantation significantly attenuates parkinsonian symptoms likely via bystander effects, specifically st… Show more

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Cited by 23 publications
(45 citation statements)
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“…Parkinson's disease (PD) is a common age-related neurodegenerative disorder due to the loss of dopaminergic neurons in the substantia nigra par compacta (SNpc) thereby leading to the dopamine depletion in the striatum (Huang et al, 2019). The clinical symptoms of PD are mainly classified into motor abnormalities characterized by static tremor, rigidity, bradykinesia, postural instability and non-motor symptoms, such as cognitive impairment and gut dysfunction (Lee et al, 2019). So far, L-3,4-dihydroxyphenylalanine (L-dopa) remains to be the most effective drug for symptomatic treatment of Parkinson (Smith et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Parkinson's disease (PD) is a common age-related neurodegenerative disorder due to the loss of dopaminergic neurons in the substantia nigra par compacta (SNpc) thereby leading to the dopamine depletion in the striatum (Huang et al, 2019). The clinical symptoms of PD are mainly classified into motor abnormalities characterized by static tremor, rigidity, bradykinesia, postural instability and non-motor symptoms, such as cognitive impairment and gut dysfunction (Lee et al, 2019). So far, L-3,4-dihydroxyphenylalanine (L-dopa) remains to be the most effective drug for symptomatic treatment of Parkinson (Smith et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Introduced expression of the GBA enzyme using an inducible viral expression system with high affinity for the peripheral nervous system in enteric neurons partially restored the GI phenotype observed in mice overexpressing the α-Syn protein in Thy1positive projection neurons [25]. However, not only is the ENS relevant to the disease etiology in the GI, rather both the gut endothelium [28], and gut microbiome contribute significantly [29][30][31][32][33]. The human body hosts a rich collection of microorganisms, most of them residing in the gut, where they are involved in food digestion as well as providing the host different by-products [34].…”
Section: Parkinson's Diseasementioning
confidence: 99%
“…5 Our recent studies in experimental Parkinson's disease (PD) reveal the critical role of the microbiome as a biomarker and therapeutic target. 9,10 The prevailing dogma in PD is its overarching classification as a brain disorder with the depletion of nigrostriatal dopamine as its key pathology; thus, its diagnosis and treatment have mainly focused on addressing this brain manifestation. A paradigm shift implicates the periphery as PD's origin.…”
mentioning
confidence: 99%
“…Indeed, gut dysbiosis precedes brain pathology, with abnormal GI functions predating the hallmark motor symptoms of PD. 9,10 Cognizant of this gut-to-brain disease propagation, probing the gut microbiome should reveal innovative insights into PD pathology and its treatment. Targeting PD at its peripheral origin may allow a disease-modifying outcome instead of the current palliative relief.…”
mentioning
confidence: 99%
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