Gynaecological surgical procedures and risk of colorectal cancer in women

Cape, D B; Kreiger, Nancy

doi:10.1097/00008469-199912000-00004

Cited by 6 publications

(4 citation statements)

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“…However, several other studies have failed to find any association between OC use and colon, rectal70,71 or colorectal cancer 72,73. In contrast to the findings of the Ontario Women’s Cohort Study, which reported a reduced risk of colorectal cancer related to TS,74,75 we found no association for colon cancer and a possible positive association for rectal cancer with TS.…”

Section: Discussioncontrasting

confidence: 99%

Use of oral contraceptives, intrauterine devices and tubal sterilization and cancer risk in a large prospective study, from 1996 to 2006

Dorjgochoo

Shu

et al. 2009

Intl Journal of Cancer

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The association of contraceptive methods, including oral contraceptives (OC), intrauterine devices (IUD) and tubal sterilization (TS), with overall and site-specific cancer were prospectively investigated in a cohort of 66,661 Chinese women in Shanghai, 76.7% of whom used contraception. During a median follow-up time of 7.5 years, 2,250 women were diagnosed with cancer. Everuse of any contraceptive method was not associated with overall cancer risk [adjusted hazard ratio (HR adj ) 5 1.02, 95% CI, 0.92-1.12]. Use of any contraceptive method was associated with increased risk of rectal cancer (HR adj 5 1.68, 95% CI, 1.08-2.62) and reduced risk of thyroid cancer (HR adj 5 0.63, 95% CI, 0.38-1.04). Risk of gallbladder cancer increased with ever use of OC (HR adj 5 2.38, 95% CI, 1.26-4.49). IUD use was associated with a possible reduced risk of thyroid cancer (HR adj 5 0.64, 95% CI, 0.38-1.07). Longer duration of IUD use decreased risk for breast, thyroid and lung cancers. Ever having a TS was associated with increased uterine body cancer (HR adj 5 2.50, 95% CI, 1.47-4.25) and decreased risk of stomach cancer (HR adj 5 0.59, 95% CI, 0.39-0.91). We did not find any contraceptive method to be related to the risk of ovarian cancer but the analyses were based on few events. Although chance findings are a likely explanation for some of the associations found in our study, these findings suggest that various contraceptive methods or reproductive patterns may play a role in the etiology of cancer.

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Section: Discussioncontrasting

confidence: 99%

Use of oral contraceptives, intrauterine devices and tubal sterilization and cancer risk in a large prospective study, from 1996 to 2006

Dorjgochoo

Shu

et al. 2009

Intl Journal of Cancer

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“…The existing evidence for the associations between hysterectomy (with and without bilateral salpingo-oophorectomy) and colorectal cancer is inconsistent, with studies reporting lower risk (15), higher risk (10,16), and (like our study) no association (11,34). These inconsistencies do not appear to be explained by self-report of surgery or adjustment for menopausal hormone therapy (MHT) use.…”

Section: Discussioncontrasting

confidence: 71%

“…In contrast, most studies have found no association between hysterectomy without oophorectomy and risk of breast cancer (10,12,13); however, one study found a lower risk in women who had a hysterectomy alone before the age of 45 years (11). While the development of colorectal cancer appears to be influenced by sex hormones (14), associations with hysterectomy (with or without bilateral salpingo-oophorectomy) have been inconsistent, with studies finding either lower (15) or higher (16) risks as well as no association (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Hysterectomy and Risk of Breast, Colorectal, Thyroid, and Kidney Cancer – an Australian Data Linkage Study

Wilson

Tuesley

Webb

et al. 2021

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: This study aimed to investigate the associations between hysterectomy for benign indications and risk of breast, colorectal, kidney, and thyroid cancer, and to explore whether these associations are modified by removal of ovaries at the time of surgery or by age at surgery. Methods: We conducted a retrospective cohort study of the female population of Western Australia (n = 839,332) linking data from electoral, hospital, births, deaths, and cancer records. We used Cox regression to estimate HRs and 95% confidence intervals (CI) for the associations between hysterectomy and diagnosis of breast, colorectal, kidney, and thyroid cancers. Results: Compared with no surgery, hysterectomy without oophorectomy (hysterectomy) and hysterectomy with bilateral salpingo-oophorectomy (hysterectomy-BSO) were associated with higher risk of kidney cancer (HR, 1.32; 95% CI, 1.11–1.56 and HR, 1.29; 95% CI, 0.96–1.73, respectively). Hysterectomy, but not hysterectomy-BSO, was related to higher risk of thyroid cancer (HR, 1.38; 95% CI, 1.19–1.60). In contrast, hysterectomy (HR, 0.94; 95% CI, 0.90–0.98) and hysterectomy-BSO (HR, 0.92; 95% CI, 0.85–1.00) were associated with lower risk of breast cancer. We found no association between hysterectomy status and colorectal cancer. Conclusions: The associations between hysterectomy and cancer varied by cancer type with increased risks for thyroid and kidney cancer, decreased risk for breast cancer, and no association for colorectal cancer. Impact: As breast, colorectal, and gynecologic cancers comprise a sizeable proportion of all cancers in women, our results suggest that hysterectomy is unlikely to increase overall cancer risk; however, further research to understand the higher risk of thyroid and kidney cancer is warranted.

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“…The strongest association was with a history of cervical intraepithelial neoplasia grade 3 (RR ¼ 4.03, 95% CI: 2.59-6.28), reflecting the importance of high-risk strains of human papilloma virus as causative agents of both cervical (Walboomers et al, 1999) example, as tubal ligation is usually performed for permanent contraception, it is likely to be more common among women who are sexually active, and who thus may be more likely to be exposed to sexually-transmitted infections, such as human papilloma virus, and the consequent increased risk of anal cancer. There have been reports on possible relationships between tubal ligation and other cancers, including possible reductions in risk of colorectal (Cape and Kreiger, 1999;Rosenblatt et al, 2004) and stomach cancer (Dorjgochoo et al, 2009), and increased risks of thyroid cancer (Braganza et al, 2014) and lymphatic and haematopoietic malignancies (Kjaer et al, 2004). We did not replicate any of these findings.…”

Section: Discussioncontrasting

confidence: 56%

Tubal Ligation and Incidence of 26 Site-Specific Cancers in the Million Women Study

Gaitskell

Coffey

Green

et al. 2017

Obstetrical &Amp; Gynecological Survey

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Gynaecological surgical procedures and risk of colorectal cancer in women

Cited by 6 publications

References 0 publications

Use of oral contraceptives, intrauterine devices and tubal sterilization and cancer risk in a large prospective study, from 1996 to 2006

Use of oral contraceptives, intrauterine devices and tubal sterilization and cancer risk in a large prospective study, from 1996 to 2006

Hysterectomy and Risk of Breast, Colorectal, Thyroid, and Kidney Cancer – an Australian Data Linkage Study

Tubal Ligation and Incidence of 26 Site-Specific Cancers in the Million Women Study

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