Gynandroblastome et syndrome de l’X Fragile. À propos d’un cas

The administration of cytotoxic therapy to patients with fragile X syndrome (FXS) presents several unique therapeutic challenges. The existence of fragile sites poses a theoretical risk of tumorigenesis and potentially increased treatment associated toxicity, however, controversy exists. We review the 42 previously reported cases of neoplasia in patients with FXS and report two novel neoplasms in patients treated with radiation therapy or combined chemoradiation. Our experience suggests that radiation therapy can be delivered safely in these patients without an expectation for increased acute/sub-acute normal tissue toxicity; however, treatment requires specialized facilities with the resources to deliver this care safely.

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Therapeutic challenges in treating patients with fragile X syndrome and neoplasia

Farach

Farach²,

Paulino

2013

Pediatr Blood Cancer

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Androgen Insensitivity Syndrome with Gynandroblastoma and Vulvar Leiomyoma

Tian

Wang²,

Zhang³

et al. 2013

Journal of Lower Genital Tract Disease

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Gynandroblastome et syndrome de l’X Fragile. À propos d’un cas

Cited by 2 publications

References 7 publications

Therapeutic challenges in treating patients with fragile X syndrome and neoplasia

Therapeutic challenges in treating patients with fragile X syndrome and neoplasia

Androgen Insensitivity Syndrome with Gynandroblastoma and Vulvar Leiomyoma

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