Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles

Razavi, Zahra; Tajiknia, Vida; Majidi, Shahab; Ghandali, Maryam; Mirzaei, Hamid Reza; Rahimian, Neda; Hamblin, Michael R.; Mirzaei, Hamed

doi:10.1016/j.critrevonc.2020.103192

Cited by 99 publications

(63 citation statements)

References 365 publications

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“…Ovarian cancer is a gynecological tumor with considerable morbidity and mortality (43,44). Chemotherapy and surgery are the main treatments for ovarian cancer, but because of multidrug resistance (MDR) these approaches are not completely successful.…”

Section: Salmonella Bacteria As Delivery Systems For Anti-tumor Agentsmentioning

confidence: 99%

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

et al. 2021

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Over the years, conventional cancer treatments, such as chemotherapy with only a limited specificity for tumors, have undergone significant improvement. Moreover, newer therapies such as immunotherapy have undergone a revolution to stimulate the innate as well as adaptive immune responses against the tumor. However, it has been found that tumors can be selectively colonized by certain bacteria, where they can proliferate, and exert direct oncolytic effects as well as stimulating the immune system. Bacterial-mediated cancer therapy (BMCT) is now one example of a hot topic in the antitumor field. Salmonella typhimurium is a Gram-negative species that generally causes self-limiting gastroenteritis in humans. This species has been designed and engineered in order to be used in cancer-targeted therapeutics. S. typhimurium can be used in combination with other treatments such as chemotherapy or radiotherapy for synergistic modification of the tumor microenvironment. Considerable benefits have been shown by using engineered attenuated strains for the diagnosis and treatment of tumors. Some of these treatment approaches have received FDA approval for early-phase clinical trials. This review summarizes the use of Salmonella bacteria for cancer therapy, which could pave the way towards routine clinical application. The benefits of this therapy include an automatic self-targeting ability, and the possibility of genetic manipulation to produce newly engineered attenuated strains. Nevertheless, Salmonella-mediated anticancer therapy has not yet been clinically established, and requires more research before its use in cancer treatment.

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Section: Salmonella Bacteria As Delivery Systems For Anti-tumor Agentsmentioning

confidence: 99%

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

et al. 2021

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“…Most miRNAs are transcribed as precursors (either pri-miRNA or pre-mRNA) before capping and polyadenylation, and their biogenesis requires several enzymes, including Drosha, DGCR8, Dicer, and Argonaute (Ago) 2 (Donker et al, 2007). In recent years, the remarkable roles of miRNAs in cellular proceedings under healthy or diseased conditions have been increasingly recognized (Aghdam et al, 2019;Mirzaei and Hamblin, 2020;Sadri Nahand et al, 2020;Davoodvandi et al, 2021;Razavi et al, 2021). In particular, several studies have shown that knocking out the key enzymes in the miRNA processing results in embryonic arrest or even embryonic death (Bernstein et al, 2003;Alisch et al, 2007;Suh et al, 2010), indicating the significance of miRNAs in the regulation of pregnant process.…”

Section: Introductionmentioning

confidence: 99%

Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy

et al. 2021

Front. Cell Dev. Biol.

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In placental mammals, reproductive success, and maternal-fetal health substantially depend on a well-being placenta, the interface between the fetus and the mother. Disorders in placental cells are tightly associated with adverse pregnancy outcomes including preeclampsia (PE), fetal growth restriction, etc. MicroRNAs (miRNAs) represent small non-coding RNAs that regulate post-transcriptional gene expression and are integral to a wide range of healthy or diseased cellular proceedings. Numerous miRNAs have been detected in human placenta and increasing evidence is revealing their important roles in regulating placental cell behaviors. Recent studies indicate that placenta-derived miRNAs can be released to the maternal circulation via encapsulating into the exosomes, and they potentially target various maternal cells to provide a hormone-like means of intercellular communication between the mother and the fetus. These placental exosome miRNAs are attracting more and more attention due to their differential expression in pregnant complications, which may provide novel biomarkers for prediction of the diseases. In this review, we briefly summarize the current knowledge and the perspectives of the placenta-derived miRNAs, especially the exosomal transfer of placental miRNAs and their pathophysiological relevance to PE. The possible exosomal-miRNA-targeted strategies for diagnosis, prognosis or therapy of PE are highlighted.

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“…Circular RNAs are widespread; however, their expression is tissue-specific. A growing body of research indicates that circRNAs are involved in various types of pathophysiology, including aging, diabetes, glycolysis ( Mirzaei and Hamblin, 2020 ), myogenesis ( Das et al, 2020 ), virus infections ( Nahand et al, 2020 ), and cancer ( Haque and Harries, 2017 ; Cai et al, 2019 ; Shabaninejad et al, 2019 ; Shang et al, 2019 ; Borran et al, 2020 ; Li et al, 2020 ; Razavi et al, 2021 ). Since circRNAs are stable and tissue-specific, many studies have explored their diagnostic and prognostic potential in cancers.…”

Section: Introductionmentioning

confidence: 99%

Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis

Khan

Jha

Panda

et al. 2021

Front. Mol. Biosci.

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Recent advances in sequencing technologies and the discovery of non-coding RNAs (ncRNAs) have provided new insights in the molecular pathogenesis of cancers. Several studies have implicated the role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and recently discovered circular RNAs (circRNAs) in tumorigenesis and metastasis. Unlike linear RNAs, circRNAs are highly stable and closed-loop RNA molecules. It has been established that circRNAs regulate gene expression by controlling the functions of miRNAs and RNA-binding protein (RBP) or by translating into proteins. The circRNA–miRNA–mRNA regulatory axis is associated with human diseases, such as cancers, Alzheimer’s disease, and diabetes. In this study, we explored the interaction among circRNAs, miRNAs, and their target genes in various cancers using state-of-the-art bioinformatics tools. We identified differentially expressed circRNAs, miRNAs, and mRNAs on multiple cancers from publicly available data. Furthermore, we identified many crucial drivers and tumor suppressor genes in the circRNA–miRNA–mRNA regulatory axis in various cancers. Together, this study data provide a deeper understanding of the circRNA–miRNA–mRNA regulatory mechanisms in cancers.

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Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles

Cited by 99 publications

References 365 publications

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy

Cancer-Associated circRNA–miRNA–mRNA Regulatory Networks: A Meta-Analysis

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