Gynecomastia Associated with Enalapril and Diazepam

Llop, Roser; Gómez-Farran, Francesc; Figueras, Albert; Capellà, Dolors; Laporte, Joan‐Ramon

doi:10.1177/106002809402800521

Cited by 9 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cough (2 to 4.3%) (Materson, 1992), Fatigue (2.6%), Serum blood urea nitrogen raised (2 to 8%), Serum creatinine raised (2 to 11%), Angioedema (0.1%) Agranulocytosis, hemolytic anemia, alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, rashes, photosensitivity reaction, dermatopolymyo-sitis (PI, 2009;Zannad, 1999;2001;Kaufman, 2013), Gynecom-astia (Hurley, 1995;Llop et al, 1994), hyperglycemia (Ostman et al, 1998;PI, 1999) and hyperkalemia (Reardon and Macpherson, 1998) are the rare adverse effect with only a few reported cases.…”

Section: Other Adverse Eventsmentioning

confidence: 99%

Risk-Benefit Analysis and Risk Minimization of Quinapril: A Review

Sunny¹

2014

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

The purpose of this review is to give the readers an insight about the risks and benefits of 'quinapril', a potent Angiotensin Converting Enzyme Inhibitor (ACEI). Quinapril is a highly effective novel drug indicated for treatment of congestive heart failure and hypertension. Despite of the fact that safety profile is quite well with low incidence of adverse effects, an attempt has been made to minimize the risks and subsequently minimizing the adverse consequences of this competitive inhibitor, thereby increasing the benefits of this enzyme inhibitor in day to day clinical practice.

show abstract

Section: Other Adverse Eventsmentioning

confidence: 99%

Risk-Benefit Analysis and Risk Minimization of Quinapril: A Review

Sunny¹

2014

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

show abstract

“…The benzodiazepines are another class of drugs that have been reported to cause gynecomastia. In particular, diazepam has been reported to induce gynecomastia . High doses of diazepam may have mammotropic effects and modify estradiol levels .…”

Section: Psychotherapeutic Agentsmentioning

confidence: 99%

“…High doses of diazepam may have mammotropic effects and modify estradiol levels . In one case series of five men who took diazepam at therapeutic doses, gynecomastia developed along with increased estradiol concentrations . When diazepam was stopped, their estradiol levels became normal and their gynecomastia resolved.…”

Section: Psychotherapeutic Agentsmentioning

confidence: 99%

Drug‐Induced Gynecomastia

2012

View full text Add to dashboard Cite

Drugs account for about 20% of gynecomastia cases in men. As a number of factors can alter the estrogen:androgen ratio, several pathophysiologic mechanisms are associated with drugs causing this disorder. Antiandrogens, protease inhibitors, and nucleoside reverse transcriptase inhibitors are the most common drug causes of gynecomastia, whereas first-generation antipsychotics, spironolactone, verapamil, and cimetidine are less common causes. Other drugs have been reported rarely as causes. Treatment may involve switching to an alternative agent or may require surgery or irradiation if the causative agent cannot be discontinued. We reviewed the literature on drug-induced gynecomastia and provided another perspective by reviewing data from the United States Food and Drug Administration's Adverse Event Reporting System. Epidemiologic studies are needed to provide a more accurate description of the frequency of drug-induced gynecomastia.

show abstract

“…Among case reports of benzodiazepine-induced gynecomastia, diazepam, which can modify estradiol levels, is most often responsible. 2,3 In our practice, we encountered one such case.…”

mentioning

confidence: 96%