Gynmema sylvestre - A Potentional Medicinal Herb

Karande, Suyog S.; Vikhe, Dattaprasad N.; Jadhav, Ravindra S.

doi:10.52711/2349-2988.2022.00032

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…Consequently, the findings obtained in the research show that the plant's leaves might have antiepileptic effects for mice, rats, and even chicks [43]. In a 2023 study, it was discovered that amphetamine significantly enhanced the anti-seizure properties of Solanum nigrum leaves in various animals [44].…”

Section: Gmentioning

confidence: 99%

Overview of the Biochemical Potential of Solanum Nigrum

Abd alKhudhur salman

2024

UTJsci

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Solanum nigrum is known locally as the nightshadesamily, and it is considered one of the widespread plants that possess great biochemical potential. This review dealt with providing a comprehensive summary of the biochemistry of this plant, as it contains Solanum nigrum. It contains an important group of biologically active substances, including flavonoids, and some phenolic derivatives. It also contains some alkaloids, epoxy derivatives, and other important compounds. These substances have important biological activity, including significant and powerful antioxidant and anti-inflammatory properties, as well as strong antimicrobial and anti-cancer properties, and other medically important properties. This plant has been used for medicinal purposes for a long time in treating many diseases. Finally, this review indicates the wide biological diversity in biochemistry. The study also touched on some potential applications in various fields, including nutrition and medicine.

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Section: Gmentioning

confidence: 99%

Overview of the Biochemical Potential of Solanum Nigrum

Abd alKhudhur salman

2024

UTJsci

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“…The leaves have also shown potential anti-arthritic activity due to triterpenoids, steroids and saponin glycosides. Other activities reported on the leaf extract were anti-microbial, anti-inflammatory, anti-hyperlipidemic, hepatoprotective and immunostimulatory [6]. Several triterpenoid saponins have been associated with a number of biological properties and cytotoxic potential, as well as apoptotic potential.…”

Section: Introductionmentioning

confidence: 99%

Anti-Tumor Potential of Gymnema sylvestre Saponin Rich Fraction on In Vitro Breast Cancer Cell Lines and In Vivo Tumor-Bearing Mouse Models

et al. 2023

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Gymnema sylvestre (GS) is a perennial woody vine native to tropical Asia, China, the Arabian Peninsula, Africa and Australia. GS has been used as a medicinal plant with potential anti-microbial, anti-inflammatory and anti-oxidant properties. This study was conceptualized to evaluate the cytotoxicity potential of Gymnema sylvestre saponin rich fraction (GSSRF) on breast cancer cell lines (MCF-7 and MDA-MB-468) by SRB assay. The anti-tumor activity of GSSRF was assessed in tumor-bearing Elrich ascites carcinoma (EAC) and Dalton’s lymphoma ascites (DLA) mouse models. The anti-oxidant potential of GSSRF was assessed by DPPH radical scavenging assay. The acute toxicity of GSSRF was carried out according to OECD guideline 425. The yield of GSSRF was around 1.4% and the presence of saponin content in GSSRF was confirmed by qualitative and Fourier transform infrared spectroscopic (FTIR) analysis. The in vitro cytotoxic effects of GSSRF on breast cancer cell lines were promising and found to be dose-dependent. An acute toxicity study of GSSRF was found to be safe at 2000 mg/kg body weight. GSSRF treatment has shown a significant increase in the body weight and the life span of EAC-bearing mice in a dose-dependent manner when compared with the control group. In the solid tumor model, the doses of 100 and 200 mg/kg body weight per day have shown about 46.70% and 60.80% reduction in tumor weight and controlled the tumor weight until the 30th day when compared with the control group. The activity of GSSRF in both models was similar to the cisplatin, a standard anticancer agent used in the study. Together, these results open the door for detailed investigations of anti-tumor potentials of GSSRF in specific tumor models, mechanistic studies and clinical trials leading to promising novel therapeutics for cancer therapy.

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A Review on Medicinal properties of Colocasia esculenta Linn

S. Lad,

U. Kolhe,

A. Devade

et al. 2023

RJPPD

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Colocasia esculenta Linn. is one of the widely available plant all over the globe with history of use in Indian traditional system. Colocasia esculenta Linn. has attained popularity across the globe to replace synthetic medicines due to their less side effects and its natural plant origin. It is commonly known as taro belonging to family Araceae. It is used as a vegetable for many nutritional as well as medicinal purposes. The two important therapeutically active chemical constituents are present in taro leaf extract namely flavonoids and triterpenoids. The pharmacological studies of Colocasia esculenta Linn. estimated that the herb showed various pharmacological activities, including nervine tonic, antioxidant, anti-inflammatory, anti-lipid peroxidative activity, hepatoprotective, antifungal, antidiabetic, anticancer and antimicrobial effects. This review is designed to give exhaustive account on taxonomy, geographical and nutritional information, various phytochemical constituents and pharmacologic activities of taro.

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Gynmema sylvestre - A Potentional Medicinal Herb

Cited by 3 publications

References 1 publication

Overview of the Biochemical Potential of Solanum Nigrum

Overview of the Biochemical Potential of Solanum Nigrum

Anti-Tumor Potential of Gymnema sylvestre Saponin Rich Fraction on In Vitro Breast Cancer Cell Lines and In Vivo Tumor-Bearing Mouse Models

A Review on Medicinal properties of Colocasia esculenta Linn

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