Gyrotrons with output powers of several 100 kW are mainly used as high-power millimeter (mm)-wave sources for electron cyclotron resonance heating (ECRH), electron cyclotron current drive (ECCD), stability control and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. Other applications include ECR ion sources, materials processing and plasma chemistry, high-resolution Doppler radar, radar ranging and imaging in atmospheric and planetary science, active denial systems, as well as detection of concealed radioactive materials. The present review summarizes the status of recent developments on high-power gyrotrons and introduces this Special Issue on Gyrotrons.