Modern Diesel engines contain sophisticated control systems to keep their environmental impact low for sustainable road transport. One of these systems is the dual loop exhaust gas recirculation, which can change combustion properties in several ways. This article presents an engine dyno measurement based on analyzing the duel loop EGR with a medium-duty Diesel engine. Intake throttles and exhaust brakes for the highest freedom in the air-fuel ratio setting support the EGR systems. The EGR modes are compared from fuel consumption, NOx emission, and exhaust gas opacity in steady and transient operations. There are expected results, for instance, in the HP EGR’s faster reaction time or the LP EGR’s boost pressure holding property. Unexpected results are also presented. Contrary to theory, LP EGR generally provides a fuel consumption advantage in many operation points due to its higher boost pressure. Typically, HP EGR can provide lower fuel consumption at higher engine power. In the emission results, LP EGR is favourable both in NOx emission and exhaust gas opacity, whereas the intake throttle-supported HP EGR usually shows the highest emission. Besides, with high EGR rates at lower engine loads, LP EGR can realize low-temperature combustion, where both emissions decrease. No difference can be detected between the LP EGR’s support valves’ results. HP EGR was faster in the transient operation, with about half the reaction time. The results can be utilized for dual-loop EGR layout and control design.