H. Y. S. T. et al., on Archiving Hysteria’s Past in the Present

Lutker, Shana; Braun, Johanna

doi:10.1007/978-3-030-66360-5_13

Cited by 5 publications

(7 citation statements)

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“…Since the strong association of HLA-B*52 with both TAK (4, 5) and UC (16,17) has been well-established, especially in individuals that concomitantly have both etiologies (9), we investigated the carrier status of HLA-B*52 in our study samples. Nearly half of the subjects tested for the HLA genotypes were HLA-B*52 carriers (99 out of 218).…”

Section: Resultsmentioning

confidence: 99%

“…Integrin avb6 is a receptor for extracellular matrix proteins and is specifically expressed in epithelial cells, rendering integrated epithelial barrier functions. UC frequently co-exists in the same individuals with TAK (~6.4% in Japanese) (9), and importantly, TAK and UC share genetic components in a global manner including HLA-B*52 and rs6871626 in IL-12B, indicating the presence of shared underlying pathogenic mechanisms. We previously reported that HLA-B*52 characterizes the co-occurrence of TAK and UC with a strong effect size in an intra-case analysis of TAK (9).…”

Section: Introductionmentioning

confidence: 99%

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Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis

Ishikawa,

Yoshida,

Yoshifuji

et al. 2024

Front. Immunol.

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BackgroundIt has been well documented that Takayasu arteritis (TAK) and ulcerative colitis (UC) coexist in the same patients. HLA-B*52 characterizes the co-occurrence, which is one of the common genetic features between these two diseases, indicating shared underlying pathologic mechanisms. Anti-integrin αvβ6 antibody (Ab) is present in sera of UC patients in a highly specific manner. We investigated if there were any associations between anti-integrin αvβ6 Ab and TAK, considering the risk HLA alleles.MethodsA total of 227 Japanese TAK patients were recruited in the current study and their serum samples were subjected to measurement of anti-integrin αvβ6 Ab by ELISA. The clinical information, including the co-occurrence of UC, was collected. The HLA allele carrier status was determined by Luminex or genotype imputation.ResultsThe information about the presence of UC was available for 165 patients, among which eight (4.84%) patients had UC. Anti-integrin αvβ6 antibody was identified in 7 out of 8 TAK subjects with UC (87.5%) while only 5 out of 157 (3.18%) TAK subjects without UC had the antibody (OR 121, p=7.46×10-8). A total of 99 out of 218 (45.4%) patients were HLA-B*52 carriers. There was no significant association between the presence of anti-integrin αvβ6 Ab and HLA-B*52 carrier status in those without UC (OR 2.01, 95% CI 0.33-12.4, p = 0.189).ConclusionsThe prevalence of anti-integrin αvβ6 Ab was high in TAK patients with UC, but not in the absence of concomitant UC. The effect of HLA-B*52 on anti-integrin αvβ6 Ab production would be minimal.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis

Ishikawa,

Yoshida,

Yoshifuji

et al. 2024

Front. Immunol.

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“…Amyloid has been identified in atherosclerotic plaques. 54 SAA1 and SAA2 -nearly identical isoforms-may play a role in atherosclerosis, both locally and systemically. In a murine atherosclerosis model, SAA expression was increased in both early and late atherosclerosis lesions.…”

Section: Clinical and Research Implicationsmentioning

confidence: 99%

Serum amyloid A1 and pregnancy zone protein in pregnancy complications and correlation with markers of placental dysfunction

Fosheim

Jacobsen

Sugulle

et al. 2023

American Journal of Obstetrics & Gynecology MFM

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“…where E latt is the lattice energy of the crystal; E slice is the energy released by growing a wafer with a thickness of d hkl . The AE model considers that the relative growth rate (R hkl ) of the crystal face in the crystal is proportional to the absolute value of the corresponding attachment energy (E att ) [22], see equation (2). The low crystal face attachment energy corresponds to a slow growth rate, which is important in morphology.…”

Section: Theorymentioning

confidence: 99%

Crystal morphology prediction of CL-20 and 1,4-DNI co-crystal at different temperatures

Song

Zhao

et al. 2023

J Mol Model

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Using the attachment energy (AE) model and molecular dynamics (MD) methods, the morphologies of hexanitrohexaazaisowurtzitane (CL-20) and 1,4-dinitroimidazole (1,4-DNI) co-crystal under vacuum or solvent at different temperatures were predicted. The CL-20/1,4-DNI co-crystal has six important growth crystal planes: (002), ( 011), ( 101), (11-1), (110), ( 111). The area of ( 002), ( 101), and (011) planes account for a relatively large proportion, which are important crystal planes that affect the crystal morphology. At the same time, by calculating the interaction energy between the solvent and the crystal plane and the attachment energies under the influence of the solvent at 298 K, 320 K, 340 K, 360 K and 380 K were predicted. The crystal habits at different temperatures were simulated. The simulation results showed that the crystal plane attachment energy of CL-20 and 1,4-DNI co-crystal increases with the increase of temperature, indicating that the increase of temperature is conducive to the growth of crystal planes. The aspect ratio decreases with the increase of temperature and the morphology of cocrystal becomes more spherical. The theoretical predictions are in good agreement with the experiment.The simulation results can provide guidance for the crystallization of CL-20/1,4-DNI to obtain a nearly spherical crystal morphology.

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H. Y. S. T. et al., on Archiving Hysteria’s Past in the Present

Cited by 5 publications

References 0 publications

Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis

Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis

Serum amyloid A1 and pregnancy zone protein in pregnancy complications and correlation with markers of placental dysfunction

Crystal morphology prediction of CL-20 and 1,4-DNI co-crystal at different temperatures

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