“…Such wide spectrum of quinazoline strongly demands possible derivatisation to test out for further pharmaceutical possibilities. Various methods have been proposed to obtained quinazoline analogues using catalysts like ammonium bromide [14], Zirconyl chloride [15] Heteropoly acids [16], Gallium (III) triflate [17], Titanium oxide nano-particles [18], Starch solution [19], cyanuric chloride [20] and Cyclodextrin sulphonic acid [21].Most of these methodologies are suffers from long reaction time, high temperature, use of expensive catalyst and tedious work procedures. 'On water' reports [22] of quinazoline synthesis by using expensive catalyst increase cost of reaction.…”