H5N1 influenza virus seroepidemiological studies: The facts revisited

Osterholm, Michael T.; Kelley, Nicholas S.

doi:10.1073/pnas.1203949109

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Spill-over events at the human-animal interface most likely occur more often than is currently recognized, as indicated by serological studies (Figure 1b, c) [40][41][42]. However, the Surveillance strategy for early detection of unusual infectious disease events Koopmans 187 same studies are subject to considerable debate, as standardization of serological tests is difficult and differences in interpretation may lead to fundamentally different risk assessments [42,43]. Case based surveillance by default is biased for disease severity, which is relevant for individual patients but only partly related to public health impact.…”

Section: Syndromic Surveillancementioning

confidence: 99%

Surveillance strategy for early detection of unusual infectious disease events

Koopmans

2013

Current Opinion in Virology

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New pathogens continue to emerge, and the increased connectedness of populations across the globe through international travel and trade favors rapid dispersal of any new disease. The ability to respond to such events has increased but the question is what 'preparedness' means at the level of the clinician. Clinicians deal with patients with unexplained illness on a daily basis, and even with syndromes highly indicative of infectious diseases, the cause of illness is often not detected, unless extensive and costly diagnostic work-ups are done. This review discusses innovations in diagnostics and surveillance aimed at early detection of unusual disease. Risk based approaches are promising, but optimal preparedness planning requires multidisciplinary partnerships across domains, and a global translational research agenda to develop tools, systems, and evidence for interventions.

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Section: Syndromic Surveillancementioning

confidence: 99%

Surveillance strategy for early detection of unusual infectious disease events

Koopmans

2013

Current Opinion in Virology

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“…The mortality associated with H5N1 virus is a key driver of the GOF risk-benefit debate. Although there seems to be no debate that the case-fatality ratio of individuals who come to medical attention with H5N1 is high, the ratio of asymptomatic to symptomatic infections has been the subject of debate in the literature ( 17 , 18 ). This is a key parameter for which additional information could become available with additional studies.…”

Section: Unanswered Questionsmentioning

confidence: 99%

Risks and Benefits of Gain-of-Function Experiments with Pathogens of Pandemic Potential, Such as Influenza Virus: a Call for a Science-Based Discussion

Casadevall

Imperiale

2014

mBio

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“…First, the basic complaint that Osterholm and Kelley make (1), that "the PNAS Perspective was an incomplete analysis and that no conclusions can be drawn from the data presented" is invalid. There was, in fact, no analysis presented in our PNAS piece-we simply cited the 10 largest studies that are available related to seroprevalence in humans.…”

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confidence: 99%