Habitat‐Dependent Variations in Berberine Content of <i>Berberis asiatica</i><scp>Roxb</scp>. ex. DC. in Kumaon, Western Himalaya

Andola, Harish Chandra; Gaira, Kailash S.; Rawal, Ranbeer S.; Rawat, Mahiraj Singh; Bhatt, Indra D.

doi:10.1002/cbdv.200900041

Cited by 60 publications

(31 citation statements)

References 12 publications

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“…Jatrorrhizine was detected in the M. borealis leaf along with magnoflorine, which was also present in the leaves of B. aristata and B. asiatica. B. aristata and B. asiatica had the highest intensity of berberine in their roots relative to stem, and this observation is in accordance with the results reported by Andola and Gaira et al (2010).…”

Section: Resultssupporting

confidence: 92%

“…The peak at m/z 355.1029 [M+H] + corresponds to chlorogenic acid (C 16 H 18 O 9 ) and was detected and recently reported from B. petiolaris by Singh et al (2014). As reported in the literature, berberine is mostly present in the root and the rhizome of the plants (Cromwell 1933;Greathouse & Watkins 1938;Andola and Gaira et al 2010). However, berberine was also identified in B. aristata leaf, which is the first report for this observation.…”

Section: Resultsmentioning

confidence: 59%

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Rapid screening for the adulterants ofBerberis aristatausing direct analysis in real-time mass spectrometry and principal component analysis for discrimination

Bajpai

Singh

Arya

et al. 2015

Food Additives & Contaminants: Part A

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Adulteration or substitution of commercial Berberis aristata and its herbal products with inferior-quality substituents is very common. Metabolic profiling of B. aristata, along with its common adulterants/contaminants/substituents such as B. asiatica, Mahonia borealis and Coscinium fenestratum, was rapidly carried out using direct analysis in real-time mass spectrometry (DART MS) to generate the chemical fingerprints for the differentiation of these species. Phytochemical analysis showed the presence of mainly alkaloids. The identified alkaloids were berberrubine, berberine, jatrorrhizine, ketoberberine, palmatine, dihydropalmatine or 7,8-dihydro-8-hydroxyberberine, berbamine and pakistanamine. Berberine, which was mainly reported from the root and stem bark of B. aristata, was also identified in the leaf along with chlorogenic acid. The DART MS data have been subjected to principal component analysis (PCA). The resulting score plots showed clustering and clear differentiation of the species and plant parts. It is thus apparent that the technique of DART MS followed by PCA is a quick and reliable method for the direct profiling of B. aristata and its adulterant plants and plant parts. The study reports the rapid analytical method to identify the possibility of illegal adulteration/contamination/substitution in potential plant materials and herbal extracts.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 59%

Rapid screening for the adulterants ofBerberis aristatausing direct analysis in real-time mass spectrometry and principal component analysis for discrimination

Bajpai

Singh

Arya

et al. 2015

Food Additives & Contaminants: Part A

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“…In addition, Berberine 155 increases the activity of antioxidant enzymes both in vitro and in vivo [81][82][83] peroxidase, as well as glutathione S-transferase in azoxymethane- 165 induced carcinogenic rats [81]. Another study showed that 166 Berberine restores the activity of superoxide dismutase in rats 167 with [115]. Berberis 243 croatica is reported as a novel source of Berberine [116].…”

mentioning

confidence: 99%

Berberine and neurodegeneration: A review of literature

Ahmed

Gilani

Abdollahi

et al. 2015

Pharmacological Reports

174

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The excessive production of reactive oxygen species in nervous tissues is considered one of the major risk factors of neurodegenerative diseases. During the last two decades, much attention has been paid to the antioxidant and anti-inflammatory activity of natural products and compounds isolated from natural products which are often characterized by high efficacy and low adverse effects. Berberine is an isoquinoline alkaloid, widely present in different medicinal herbs, especially in the genus Berberis. It is mainly used as antidiarrhoeal, antibacterial, antifungal, and antiprotozoal agent. However, current research has focused on its beneficial role in neurodegenerative diseases, mainly due to its powerful antioxidant effect. The therapeutic potential of Berberine in different neurodegenerative diseases such as Alzheimer, Parkinson and Huntington disease has been brought to evidence by numerous studies. However, a limited number of reviews focus on the beneficial role of Berberine against neurodegeneration. The main objective of this review is to discuss the role of oxidative stress in neurodegeneration and the potential role of antioxidant compounds, in particular Berberine which is analyzed in its chemical structure, source, bioavailability, therapeutic potential, with special attention to its mechanism of action at a molecular level.

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“…In the literature, there are various reports regarding the total alkaloid content of dry roots. For instance, B. thunbergii (3.47%) and B. vulgaris (2.22%) [31] show lower percentages than those found in B. microphylla, which may be due to the content of berberine, which is the main alkaloid, varying considerably with altitude and soil conditions for the root [31][32][33]. Total flavonoids were reported as mg equivalents of quercetin.…”

Section: Quantitative Analysismentioning

confidence: 99%

Phytochemical Constituents of the Root of Berberis Microphylla

Furrianca

Alvear

Zambrano

et al. 2017

Asian J Pharm Clin Res

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Objective: To objective of this work was to perform phytochemical qualitative and quantitative analyzes of the main secondary metabolites in the root of Berberis microphylla. Methods:The extracts of B. microphylla root were tested through phytochemical screening and the quantification of the most important constituents was carried out using spectrophotometric and gravimetric techniques.Results: Phytochemical screening of both extracts showed the presence of alkaloids, flavonoids, glycosides, cardiac glycosides, saponins, terpenes, and tannins, which are pharmacologically important. Quantification of the major phytochemicals groups showed that the ethanolic extract contains 3.9% alkaloids, 0.46% flavonoids, 9.53% tannins, and 3.60% saponins. Similarly, the methanolic extract contains 6.61% alkaloids, 0.41% flavonoids, 7.40% tannins, and 1.43% saponins. Conclusion:This is the first time that the presence of tannins, flavonoids, and saponins in this plant has been reported. The medicinal properties of the root of B. microphylla may exist due to the presence secondary metabolites.

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Habitat‐Dependent Variations in Berberine Content of Berberis asiaticaRoxb. ex. DC. in Kumaon, Western Himalaya

Cited by 60 publications

References 12 publications

Rapid screening for the adulterants ofBerberis aristatausing direct analysis in real-time mass spectrometry and principal component analysis for discrimination

Rapid screening for the adulterants ofBerberis aristatausing direct analysis in real-time mass spectrometry and principal component analysis for discrimination

Berberine and neurodegeneration: A review of literature

Phytochemical Constituents of the Root of Berberis Microphylla

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