Hæðarveiki og tengdir sjúkdómar

Protective effect and mechanism of Polygonatum kingianum against hypoxia-induced injury

“…Hypoxia is a pathological condition due to the lack of oxygen in the whole body or specific body organs and tissues. Organisms could suffer from a series of stress reactions in response to a hypoxic environment, causing hypoxia damage to many vital organs, including the lung, brain, heart and gastrointestinal tract, and even leading to death in severe cases [ 1 , 2 ]. Acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), high altitude cerebral edema (HACE) and chronic mountain sickness (CMS) are common high altitude hypoxic diseases [ 3 ].…”

High-altitude cerebral edema manifesting as T2/FLAIR hyperintensity and microbleeds in the white matter on MRI brain

“…Although acclimatization is a natural physiological adaptation to certain environmental situations, the body requires a certain time to adapt to a new environment. High-altitude cerebral edema (HACE) is a rare type of acute mountain illness characterized by consciousness disruption and truncal ataxia [2] . These symptoms are caused by vasogenic edema, and microbleeds in the white matter and corpus callosum are frequent MRI findings [3] .…”

Preliminary screening of biomarkers in HAPE based on quasi-targeted metabolomics

“…As a severe type of acute altitude sickness, HAPE can occur in first-time visitors or in those who return to high plateaus after living at lower altitudes ( Jensen and Vincent, 2022 ). HAPE is caused by sudden exposure to the plateau environment, which causes pulmonary artery pressure, pulmonary blood volume, pulmonary circulation disorders, and microcirculation internal fluid leakage to the lung interstitia and alveoli ( Gudbjartsson et al, 2019 ).…”