Hæmangioxanthoma of the Brain: A Study of Eight Cases of So‐called “Pseudoxanthomatous” Hæmangioblastoma.

Vj, McGovern; Bd, Wyke

doi:10.5694/j.1326-5377.1948.tb97135.x

Cited by 11 publications

(1 citation statement)

References 12 publications

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“…Pericytes have also been found [4-6, 11, 20, 35]. The lipidcontaining stromal cells are unlike other normal or pathological cell types and their histogenesis remains unresolved [5,26,29,30].…”

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confidence: 99%

Selective localization of ?-enolase in stromal cells of cerebellar hemangioblastomas

Feldenzer

McKeever

1987

Acta Neuropathol

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Three cases of cerebellar hemangioblastoma were studied using the immunoperoxidase technique to localize gamma-enolase, also known as neuron-specific enolase. The stromal cells demonstrated positive staining for gamma-enolase, while endothelial cells and pericytes showed no reactivity. Two vascular lesions, an angiosarcoma and a cutaneous angioma, were studied and found to be nonreactive for gamma-enolase. All tumors were also tested for factor VIII/von Willebrand factor, glial fibrillary acidic protein, and the S-100 protein. The lack of expression of gamma-enolase in endothelial cells of hemangioblastomas demonstrates a clear antigenic distinction from neighboring gamma-enolase-positive stromal cells. The significance of this finding and its implications for stromal cell histogenesis are discussed.

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confidence: 99%

Selective localization of ?-enolase in stromal cells of cerebellar hemangioblastomas

Feldenzer

McKeever

1987

Acta Neuropathol

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Cerebellar hemangioblastoma: Histogenesis of stroma cells

Kawamura

García

Kamijyo

1973

Cancer

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Light and electron microscopic features of a cerebellar hemangioblastoma were evaluated with special emphasis on the matter of the origin of interstitial (stroma) cells. Many of the capillary components were of embryonal type, and the stroma cells shared several morphological features with them. It was concluded that the stroma cells originate from vasoformative elements (endothelium and pericytes) and that the endothelial cells are active components of the neoplasm. No convincing morphological counterpart for the erythropoietic activity of this neoplasm was uncovered. Structures identical to ciliary rootlets were identified in many endothelial cells.

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Cerebellar capillary hemangioblastoma: Its histogenesis studied by organ culture and electron microscopy

Spence

Rubinstein

1975

Cancer

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A capillary hemangioblastoma from the vermis of a 21‐year‐old man with von Hippel‐Lindau's disease was successfully maintained in organ culture systems on Millipore filter platforms and gelatin sponge foam matrices up to 48 days. Three cell types—endothelial cells, pericytes, and stromal cells—identified by their fine structural features and their architectural relationships to vascular lumens and to the extracellular space were recognized in the original tumor. By light microscopy the explants showed, in the late stages, increased lipid droplets in the stromal cells and perivascular hyaline thickening. By electron microscopy, endothelial cells, pericytes, and stromal cells remained distinguishable as cell types. However, the stromal cells demonstrated, in addition to an increase of their normal complement of microfilaments and lipid droplets, features that were more characteristic of the two other cell types, i.e. micropinocytotic vesicles and the formation of zonula occludens junctions and hemidesmosomes. Basement membranes also became more apparent around the stromal cells. With increasing time in vitro, there was a striking increase in mature collagen fibers in the extracellular space. The roles of the different cell types in capillary hemangioblastoma and the histogenesis of the stromal cells are discussed in light of these observations. It is concluded that the capillary hemangioblastoma consists of multiple cell lines—endothelial cells, pericytes, stromal cells and, occasionally, hematopoietic cells—all of which are neoplastic and replicate in parallel with one another. Stromal cells may be regarded as an aberrant monopotential cell type which shares with the endothelial cell and pericyte a common mesenchymal, presumably angiogenic, ancestry, and may, on occasion, display morphological features, such as increased basement membrane formation and the formation of zonula occludens junctions, which recall its angiogenic lineage. However, interconvertibility between endothelial cells and stromal cells does not appear to occur in vivo or in vitro.

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Hæmangioxanthoma of the Brain: A Study of Eight Cases of So‐called “Pseudoxanthomatous” Hæmangioblastoma.

Cited by 11 publications

References 12 publications

Selective localization of ?-enolase in stromal cells of cerebellar hemangioblastomas

Selective localization of ?-enolase in stromal cells of cerebellar hemangioblastomas

Cerebellar hemangioblastoma: Histogenesis of stroma cells

Cerebellar capillary hemangioblastoma: Its histogenesis studied by organ culture and electron microscopy

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