Haematological and immunological findings in bone marrow aplasia

Huhn, D.; Fateh‐Moghadam, A.; K, Demmler; Kronseder, Angelika; Ehrhart, H

doi:10.1007/bf01466851

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Several authors have speculated about a role of autodestructive im munity in the pathogenesis of aplastic anaemia [3,12,19,33,39,43], De spite extensive studies, no evidence for antibody antigen complexes has been found in the bone marrow of patients suffering from aplastic anae mia [36]. A cellular cytotoxic mechanism was suggested in 1 patient de scribed by A scen sa o et al [2], We encountered a few patients who ful filled all of the criteria for aplastic anaemia and also exhibited auto-im mune haemolysis.…”

Section: Discussionmentioning

confidence: 99%

“…The unchanged pattern and ex tent of the abnormalities we observed may indicate the switching on of a pathologic clone of stem-cell able to survive for prolonged periods. This may be correlated with the finding of persistent abnormalities in peripher al blood counts, bone marrow histology, and colony-forming capacity in vitro [17,19,44]. The possibility that potential leukaemic disorders are hidden in this group cannot be ruled out [35], To exclude paroxysmal-noc turnal haemoglobinuria, sucrose-lysis and acid-lysis tests were performed repeatedly.…”

Section: Discussionmentioning

confidence: 99%

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Acquired Aplastic Anaemia in Adults

Haak¹,

Hartgrink-Groeneveld²,

Eernisse³

et al. 1977

Acta Haematol

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In a retrospective analysis of 40 aplastic anaemia patients, an attempt was made to determine prognostic parameters permitting discrimination between short survivors( < 6 months) and long-term survivors ( > 6 months). Short survival proved to be significantly associated with a persistently low reticulocyte index and progressive neutropenia. Other factors such as bone marrow cellularity, HBF level, aetiology, or presenting signs were not indicative Chromosomal aberrations were found in one third of the cases examined, but none had developed into a leukaemic stage after an observation period of 2–5 years. None of the patients with cytogenetic aberrations showed complete restoration of haematopoiesis, in contrast to several of the patients without chromosomal abnormalities. In this series, drug-associated aplastic anaemia was found more often in the short-survival group. These clinical findings indicate that the term ‘aplastic anaemia’ covers a heterogenous group of disorders

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acquired Aplastic Anaemia in Adults

Haak¹,

Hartgrink-Groeneveld²,

Eernisse³

et al. 1977

Acta Haematol

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“…Histological descriptions of marrow biopsy specimens in aplastic anaemia are rare (Kirsbaum et al, 1971;Burkhardt, 1974a, b;Duhamel, 1974;Erslev, 1974;Haas, 1974;Huhn et al, 1975) and mostly very short. Histological details referring to and positively correlating with prognosis are to the best of our knowledge unknown (Corrigan, 1974).…”

mentioning

confidence: 99%

Histological Investigation of Methacrylate Embedded Bone Marrow Biopsy Specimens; Correlation With Survival After Conventional Treatment in 15 Adult Patients

Velde

Haak

1977

Br J Haematol

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Aplastic anaemia is a rare disease with a poor prognosis: 40% of the patients die within 6 months after diagnosis. The clinical condition and laboratory data show only a poor correlation with the chance of survival for longer than 6 months. Conventional bone marrow biopsy investigations did not have any predictive value, but methyl-methacrylate embedded biopsy material from 15 patients given only supportive care showed histological features considered important for the assessment of the prognosis. In 3 micron methacrylate sections non-myeloid cells, like lymphocytes, could be readily distinguished from erythropoietic cells. Three types of inflammatory infiltrate were easily distinguished according to amount and distribution. Seven of the eight patients with marked infiltration (Grade III) died within 6 months after biopsy, but none of the patients with a sparse infiltrate (Grade I), including five patients in remission. In six of 10 patients, who were not in remission, histological data permitted correction of the clinically estimated prognosis.

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