Haematological and Serum Biomarker Responses in Heteropneustes fossilis Exposed to Bisphenol A

Srivastava, Bhawna; Reddy, Priyanka

doi:10.46488/nept.2020.v19i04.024

Cited by 3 publications

(1 citation statement)

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“…The blood lysis after the treatment with bisphenol A was might be due to oxidative stressinduced cell and membrane damage in erythrocytes of rats (Suthar et al, 2014). The significant (p<0.05) production of platelets and WBCs were observed in the BG1 group because of the immunogenic response to deal with infectious conditions after BPA exposure (Srivastava and Reddy, 2020). It was reported in literature that high levels of BPA administration gradually increased the degree of cellular infiltration and the number of Kupffer cells (Verma and Sangai, 2009;Kamel et al, 2018).…”

Section: Hematological Analysismentioning

confidence: 94%

Effectiveness of Cinnamomum cassia against Liver and Kidney Biochemical Assay and Hematology in Bisphenol-A Induced Rats

Iqbal,

Yasmeen

2023

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B isphenolA (BPA) is an organic chemical commonly used in the manufacturing of polycarbonates, epoxy resins, and other polymer products as a monomer or additive. Its most important applications are the formation of polyacrylate resins, polyester resins, flame retardants, polysulfone resins, and polyethylene resin (Huang et al., 2011;Almeida et al., 2018).Although, it is a well-studied endocrine disruptor Abstract | Bisphenol-A (BPA) exhibits toxic, endocrine, mutagenic and carcinogenic effects in living organisms. However, some dietary elements, such as cinnamon is gaining attention as it has antioxidant effects both in vivo and in vitro. The present research study was designed to see the effect of cinnamon against BPA induced Sprague Dawley rats. In the study Sprague Dawley rats of an average 300 gram body weigt were used. The rats were divided into control and treated groups. The control group was comprised of normal control (C; untreated), vehicle control (P; treated with 1ml olive oil), and positive control (BG1; only treated with BPA). Treated groups were included the pretreated group (CG2; pretreated with C. cassia at 225 mg/ kg/BW 24 hours before BPA) and the post-treated group (CG3; post-treated with C. cassia at 225 mg/kg/ BW 24 hours before BPA). In the experiment Sprague Dawley rats were fed by BPA that was followed by the intake of C. cassia at 225 mg/kg/BW of the rat. Liver (Total bilirubin, alkaline phosphate test, Lactate dehydrogenase, and alanine amino transferase) and kidney (Blood Urea Nitrogen, Creatinine, and Uric acid) biomarkers were assessed. The highest levels of ALT and ALP were linked to liver injury and a higher weight in the liver were observed in BPA treated rats as compared to the control group. Similarly, an increase in blood parameters were recorded in BPA treated rats followed by post -treated rats and pre-treated group. It was concluded by the study that BPA have pronounced adverse effects in the exposed animals particularly in BPA and cinnamon post-treated rats as compared to pre-treated rats.

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Section: Hematological Analysismentioning

confidence: 94%

Effectiveness of Cinnamomum cassia against Liver and Kidney Biochemical Assay and Hematology in Bisphenol-A Induced Rats

Iqbal,

Yasmeen

2023

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Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress

et al. 2023

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Heavy metal toxicity arising from the industrial effluents repercussions on oxidative stress, liver enzymes and antioxidant activity in brain homogenates of Oreochromis niloticus

Ishaq,

Jabeen,

Arshad

et al. 2023

Sci Rep

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Industrial effluents reaching to the aquatic ecosystem is one of the major causes of environmental pollution and exposure to industrial effluents containing harmful substances may be a serious threat to human health. Therefore, the present study aimed to determine the sub-lethal (1/5th of predetermined LC50) impact of industrial effluents from Sundar Industrial Estate on Oreochromis niloticus with proper negative control. The physicochemical analysis of industrial effluents showed enormous loads of inorganic pollutants and exhibited high mean levels of heavy metals, Mn, Fe, Pb, Ni, Cr, Hg, As, Zn and Fe with statistically significant differences at p < 0.05. Highest level of Mn and Fe was detected in effluent’s samples as 147.36 ± 80.91 mg/L and 90.52 ± 32.08 mg/L, respectively. Exposure led to increase in serum biochemical parameters alanine aminotransferase + 25%, aspartate aminotransferase + 20% and alkaline phosphatase + 7% over control although superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione significantly increased as 3.42, 2.44, 4.8 and 8 folds, respectively in metabolically active tissue brain which indicated stress caused by industrial effluents. The results concluded that industrial effluent has potent oxidative stress inducers on one hand whereas histoarchitectural and physiological toxicity causing contaminants on the other. This condition may adversely affect the health of aquatic organisms, the fish and ultimately the human beings.

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Haematological and Serum Biomarker Responses in Heteropneustes fossilis Exposed to Bisphenol A

Cited by 3 publications

References 0 publications

Effectiveness of Cinnamomum cassia against Liver and Kidney Biochemical Assay and Hematology in Bisphenol-A Induced Rats

Effectiveness of Cinnamomum cassia against Liver and Kidney Biochemical Assay and Hematology in Bisphenol-A Induced Rats

Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress

Heavy metal toxicity arising from the industrial effluents repercussions on oxidative stress, liver enzymes and antioxidant activity in brain homogenates of Oreochromis niloticus

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