Haematological criteria in haemoglobinopathy-free adult Egyptians

Habib, Zacharias

doi:10.1111/j.1601-5223.1981.tb01423.x

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Comparing our hematological findings shown in Table 4 with other studies, our calculated means are close to those reported by Zacharias Habib (2009) in Egypt [16]. The means reported in that study were: male 5.07, 87.82 and female 4.47, 84.4 for RBCs and MCV respectively and ours were: male 4.43, 87.5 and female: 4.19, 87.5 respectively.…”

Section: Hematological Characteristics Of the Study Groupssupporting

confidence: 77%

Prevalence of Beta-Thalassemia Trait Among Students of the University College of Science and Technology-Palestine

Saqer¹,

Almasri²,

Almasri³

et al. 2016

AJLS

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Abstract:Thalassemias are a group of recessively inherited genetic disorders mostly common in the Mediterranean, the equatorial and near equatorial regions of Africa and Asia. Large number of mutations cause abnormal globin gene expression and result in complete absence or reduction of globin chain synthesis which lead to thalassemia. β-thalassemia is the result of deficient or absent synthesis of β-globin chains, leading to excess α chains. This study was conducted in order to determine the prevalence of β-thalassemia trait among students of University College of Science and Technology (UCST) in Khan Younis, Gaza Strip-Palestine. Allele Specific PCR (ASPCR) was used to determine the intervening sequence IVSI-6 (T→C) and IVSI-110 (G→A) mutations. The study population consisted of 348 subjects recruited from the UCST (144 males: 41% and 204 females: 59%). Blood samples were collected in EDTA tube for CBC. Mentzer index was calculated for all samples. Blood film was done and stained using Giemza stain. DNA was isolated from 12 samples that had normal RBCs and low MCV and whose Mentzer index was >13. These samples were subjected to Allele Specific PCR in order to detect IVSI-6 (T→C) and IVSI-110 (G→A) mutations. The hemoglobin level in females was found to be about 20% less than the level recorded in males (11.40±1.01 vs 14.30±0.79 g/dl). The results also revealed that there were significant differences in all measured CBC parameters and indices between males and females except that for WBC, RBC, MCHC and PLT. IVSI-6 (T→C) mutation was detected only in two samples and both were heterozygous. IVSI-110 (G→A) mutation was not detected in this study. The present results showed that the case of β-thalassemia carrier have normal RBC, MCH, Hb and normal Mentzer index which could be missed in routine screening test.

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Section: Hematological Characteristics Of the Study Groupssupporting

confidence: 77%

Prevalence of Beta-Thalassemia Trait Among Students of the University College of Science and Technology-Palestine

Saqer¹,

Almasri²,

Almasri³

et al. 2016

AJLS

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“…Table I presents the results of the haematological studies. The Egyptian normal controls were also examined in the same laboratory (HABIB 1981). The haematocrit (Hct), haemoglobin (Hb), red blood cells ( R C), mean red cell volume (MCV) and the mean red cell haernoglobin (MCH) of the 6-yearold proposita were lowcr than in the 15-year-old propositus.…”

Section: Methodsmentioning

confidence: 99%

Homozygousβ thalassaemia in Egypt

Habib

2009

Hereditas

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Thalassaemia in the Egyptian population

Habib¹,

Böök

2008

Hereditas

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The screening for thalassaemia syndromes in Egypt was carried out on a random sample of 505 individuals of Egyptian stock. We found 10 true β thalassaemia heterozygotes, one β and δ thalassaemia heterozygote in trans position, one haemoglobin variant, possibly D, with a non‐interacting thalassaemia, one δβ thalassaemia heterozygote, and one individual with heterocellular hereditary persistence of fetal haemoglobin. No sickle cell trait or haemoglobin H was discovered. While the minimum estimate of the prevalence of the β thalassaemia trait in Egypt is about 2.6 %, the maximum is about 4 %. The prevalence of the α thalassaemia trait is probably about 2.6 %. Thalassaemia is present in both Moslems and Christians of Egypt.

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Haematological criteria in haemoglobinopathy-free adult Egyptians

Cited by 3 publications

References 7 publications

Prevalence of Beta-Thalassemia Trait Among Students of the University College of Science and Technology-Palestine

Prevalence of Beta-Thalassemia Trait Among Students of the University College of Science and Technology-Palestine

Homozygousβ thalassaemia in Egypt

Thalassaemia in the Egyptian population

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