Haematological indices  and  electrolyte status in sickle cell disease at rural hospital of central Maharashtra.

Meshram, Ajay; Bhatkulkar, Priyanka A; Khare, Ruchir; Pazare, Komal

doi:10.5455/ijmsph.2014.230820141

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…17 The significantly higher levels of serum potassium in the sickle cell patients as compared with the controls agree with previous studies. 10,11,20 Cell dehydration and hypoxia usually encountered by sickle cell patients might have caused the loss of potassium from the cell into the extracellular fluid, 21,22 thus increasing the concentration of potassium in the serum. Consequently, blood flow will be slower than normal, as a result of the dehydrated sickled erythrocytes, leading to vaso-occlusion in most cases.…”

Section: Discussionmentioning

confidence: 99%

Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra

et al. 2019

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The activity of Na+-K+ ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The study was a case-control cross-sectional study involving 120 SCD patients in the steady state and 48 ‘healthy’ controls. The SCD patients were made up of 69 HbSS patients and 41 HbSC patients. Serum electrolyte levels (Na+, K+, and Cl−) were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS; Varian Australia Pty Ltd). Serum sodium levels were significantly lower in the sickle cell patients, compared with their ‘healthy’ counterparts ( P = .0001). Although the study found significantly higher serum levels of potassium in the SCD patients ( P = .0001), there was no significant difference in serum chloride levels between patients with SCD and the controls ( P = .098). Serum sodium and chloride levels were not significantly different in both HbSS and HbSC patients ( P = .197 and P = .553, respectively). The level of serum potassium in the HbSS patients was, however, significantly higher compared with those with the HbSC genotype ( P = .0001). There is higher efflux of K+ from the intracellular into the extracellular space in HbSS patients, which may lead to red cell membrane dysfunction and associated complications.

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Section: Discussionmentioning

confidence: 99%

Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra

et al. 2019

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“…3 Similarly, other studies also reflected reduced serum sodium and raised serum potassium in SCD cases than the healthy control group. 16,17 Deoxygenation of the sickle cell RBCs is prone to altered cation permeability primarily attributed to red cell membrane Na þ -K þ ATPase activity activation. Because of intracellular dehydration, the MCHC in sickle cell RBCs seems to be raised.…”

Section: Discussionmentioning

confidence: 99%

Clinical implication of changes in serum cations and anions on clinical severity in sickle cell disease: A case–control study in a tertiary center

Patel,

Chandrakar,

Wasnik

et al. 2023

JLP

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Introduction Vaso-occlusive crisis in sickle cell disease (SCD) is related to disproportionate serum ions distribution. The objective was to evaluate the influence of changes in serum cations and anions on clinical severity in SCD patients. Materials and Methods The case–control study included 26 SCD cases and 27 apparently healthy control individuals. The cases were further grouped as crisis state and steady state cases. Each participant was assigned a disease severity score. All study participants were evaluated for serum electrolytes, osmolality, calcium, magnesium, phosphorus, total protein, and albumin. Results The mean serum sodium (135.65 mmol/L), chloride (99.88 mmol/L), calcium (2.28 mmol/L), magnesium (0.76 mmol/L), osmolality (285.19 mOsm/kg), and albumin (0.59 mmol/L) were grossly reduced in cases than the control group. The SCD crisis group recorded low serum sodium (p = 0.01), calcium (p = 0.011), total cations (p = 0.023), anions (p = 0.008), and cation–anion ratio (p = 0.041). Of all the cations, serum calcium correlated inversely with disease severity score (r = –0.367, p = 0.033), whereas serum albumin among the serum anions influenced severity the most (r = –0.338, p = 0.046). The cutoff values for serum calcium and albumin were, respectively, 2.41 and 0.63 mmol/L, with a sensitivity of 83.3 and 88.9%. A calculated ratio of serum sodium–albumin revealed a positive relationship with the severity score (r = 0.328, p = 0.05) with a sensitivity of 94.4% for a cutoff value of 208.45. Conclusion Low serum sodium, calcium, albumin, and raised sodium–albumin ratio were linked to the crisis state, and routine estimation of these parameters will help in the early assessment of the clinical severity and initiate appropriate fluid management.

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“…Electrolytes such as sodium (Na + ), potassium (K + ), chloride (Cl -), and bicarbonate (HCO3 -) play various vital roles in the body and are required for the optimal functioning of cells and organs [15,16]. Sodium is one of the major cations and functions in regulating the total amount of water in the body [17].…”

Section: Introductionmentioning

confidence: 99%

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Nnaji¹,

Oguji²,

Orji³

et al. 2022

World J. Adv. Res. Rev.

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Background: Sickle cell disease is a common genetic disorder mainly characterized by vascular occlusion and haemolysis and it constitutes a major public health problem. The aim of this study is to assess the serum electrolyte levels in sickle cell patients attending the University of Nigeria Teaching Hospital, Enugu. Materials and methodology: A total of 66 subjects, ages 18 – 40 years, were recruited for this study with thirty sickle cell subjects (female = 16, Male = 14) as test subjects and thirty non-sickle cell subjects (female = 21, male = 9) as control subjects. A total of 5mls of venous blood was collected from each subject. The serum obtained from each sample was analyzed for serum electrolytes (sodium, potassium, chloride, and bicarbonate) by potentiometry using a sensacore autoanalyzer. The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 22. Results: Anthropometric results obtained from this study showed a significant decrease (P < 0.05) in mean ± SD of systolic blood pressure, diastolic blood pressure, and body mass index (BMI) in the test subjects compared to the control subjects respectively. The electrolyte analyses showed a significant increase (P < 0.05) in mean ± SD of potassium and chloride in the test subjects compared to the control subjects respectively. The control subjects have a non-significant increase (P > 0.05) mean ± SD of sodium compared to the sickle cell subjects while the sickle cell subject has a non-significant increase (P > 0.05) mean ± SD of bicarbonate compared to the control subjects. There was a positive correlation between sodium and bicarbonate, while in the other parameters; no significant correlation existed. Conclusion: This study concludes that sickle cell anaemia subjects are predisposed to electrolyte variations, hence, the need to check these electrolyte values in sickle cell subjects.

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Haematological indices and electrolyte status in sickle cell disease at rural hospital of central Maharashtra.

Cited by 4 publications

References 14 publications

Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra

Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra

Clinical implication of changes in serum cations and anions on clinical severity in sickle cell disease: A case–control study in a tertiary center

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

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