Haematopoietic Potential of Ethanolic Leaf Extract of Talinum triangulare in Wistar Rats

Airaodion, Augustine I.; Ogbuagu, Emmanuel O.; Ekenjoku, John A.; Ogbuagu, Uloaku; Airaodion, Edith O.

doi:10.9734/ajrb/2019/v5i230084

Cited by 23 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The augmented level of liver biomarkers is the key indication of liver injury. The current study concluded that pretreatment with moringa significantly restored these elevations due to its high antioxidant potential and its ability to scavenge free radicals ( 45 ). Similar outcomes were mentioned by Islam and Alam ( 46 ), where the protective activity of M. oleifera Lam.…”

Section: Discussionmentioning

confidence: 72%

Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury

et al. 2022

View full text Add to dashboard Cite

IntroductionPhytochemicals present in Moringa oleifera (M. oleifera) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.MethodsPhytochemical and antioxidant potential of M. oleifera leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.Results and discussionsThe toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with M. oleifera ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the M. oleifera treated group in comparison to positive control (hepatotoxic rats). M. oleifera leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. M. oleifera leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases.

show abstract

Section: Discussionmentioning

confidence: 72%

Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury

et al. 2022

View full text Add to dashboard Cite

show abstract

“…When compared to the normal control, rats intoxicated with potassium bromate had raised levels of creatinine, urea, and uric acid-all crucial nephrotic indicators. Renal illness is characterised by severe liver disease with cell death that impairs the urea cycle and results in decreased glomerular filtration, retention of urea, and urea excretion [38]. Kidney impairment is indicated by a build-up of creatinine in the blood [39].…”

Section: Discussionmentioning

confidence: 99%

Protective and Curative Potential of Ethanol Leaf Extract of Corchorus olitorius against Potassium Bromate-Induced Renal Toxicity

Abali

Nwobodo

Uche

et al. 2023

AJBGMB

View full text Add to dashboard Cite

Aim: The objective of this study was to assess the protective and curative potential of ethanol leaf extract of Corchorus olitorius against potassium bromate (KBrO3)-induced renal toxicity. Methodology: Corchorus olitorius was extracted using a soxhlet extractor and ethanol as the solvent. After becoming accustomed to the lab, 24 mature male Wistar rats were randomly assigned to groups A, B, C, and D. Group A received oral distilled water as treatment. Animals in groups B, C, and D got 100 mg/kg body weight of potassium bromate while groups C and D also received 100 and 200 mg/kg body weight of Corchorus olitorius respectively. Fresh potassium bromate and groups C and D extract were administered to rats every day by oral gavage. After taking the drug for the recommended 28 days, blood and kidney samples were collected. Renal biomarkers were evaluated using conventional methods. Results: Significant (P0.05) increase in the serum concentrations of creatinine, urea, uric acid, sodium (Na+), potassium (K+), chloride (Cl–), and bicarbonate (HCO3–) were observed following potassium bromate administration in comparison to the control group. KBrO3 poisoning also increased the levels of the inflammatory proteins interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-) in the kidneys compared to the control group. Yet when KBrO3 and C. olitorius leaf extract were administered together, levels of all kidney indicators were significantly reduced in a dosage-dependent manner, with 200 mg/kg being the most efficient dose. Conclusion: This study found that C. olitorius leaf extract, particularly at the higher dose of 200 mg/kg, was successful in reducing a number of the parameters examined that had been negatively impacted by KBrO3. It may be advantageous to include C. olitorius leaf in edible products that may contain KBrO3, such as flour, bread, or cakes, as it is a well-known dietary prebiotic with established safety profiles in humans. Further research is required to determine whether C. olitorius leaves can reduce the toxicity of KBrO3 in human organs and other animal strains, as well as perhaps treat it.

show abstract

“…The filtrate was subsequently evaporated to dryness using a rotary evaporator at 45°C. Before usage, the extract was collected into an air tight container and refrigerated (Airaodion et al, 2019).…”

Section: Preparation Of Extractmentioning

confidence: 99%

Antidiabetic and Antioxidative Potentials of Aqueous Extract of Cola Acuminata Leaves in Alloxan-Induced Diabetes Mellitus in Male Albino Rats

Victoria¹,

Stephen²,

Ruth³

et al. 2023

AAVS

View full text Add to dashboard Cite

Numerous body organs (eyes, liver, kidney and testes) eventually suffer damage as a result of elevated blood glucose levels, which are a defining feature of the metabolic disorder known as diabetes mellitus. Researchers are in search for safe drugs that can bring a total recovery from diabetes. Thirty (35) male wistar rats were divided into six (7) groups of five animals each to study the antidiabetic and antioxidative properties of young Cola acuminata leaves aqueous extract. Diabetes was induced using alloxan monohydrate.5 ml of normal saline was given to group I , group 2 received 5 mg/kg/ body weight of the standard drug glibenclamide, group 3 was given 140 mg/kg of alloxan while groups Young C. acuminata leaves aqueous extract was administered orally in graded doses to the diabetic animals (50mg/kg, 100mg/kg, 200mg/kg and 400mg/kg bodyweight) and glibenclamide. Results showed a significant reduction of blood glucose level in the extract-treated rats (p <0.5) especially at 200 mg/kg and 400 mg/kg body weight. Samples were obtained for some biochemical (parameters) related to oxidant and antioxidants such as antioxidant enzymes, Reduced glutathione (GSH) activity, Superoxide dismutase (SOD) activity and Malondialdehyde (MDA) activity. When compared control and glibenclamide-treated rats, the antioxidant activity of the extract increases with advancing the dose of treatment. According to the findings, Cola acuminata young leaves have comparable antidiabetic efficacy to that of a glibenclamide administration. This suggests a promising prospect in developing novel drugs for treating diabetes mellitus.

show abstract

Haematopoietic Potential of Ethanolic Leaf Extract of Talinum triangulare in Wistar Rats

Cited by 23 publications

References 10 publications

Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury

Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury

Protective and Curative Potential of Ethanol Leaf Extract of Corchorus olitorius against Potassium Bromate-Induced Renal Toxicity

Antidiabetic and Antioxidative Potentials of Aqueous Extract of Cola Acuminata Leaves in Alloxan-Induced Diabetes Mellitus in Male Albino Rats

Contact Info

Product

Resources

About