Haematuria in patients with haemophilia and its influence on renal function and proteinuria

Benedik-Dolničar, Majda; Benedik, M

doi:10.1111/j.1365-2516.2007.01445.x

Cited by 14 publications

(21 citation statements)

References 13 publications

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“…Van den Putte found a trend ( P = 0.05), but the information is based on a single question reported by patients and the paper does not clarify whether there was a correlation between renal functioning and haematuria episodes . It is known that other causes for haematuria apart from renal bleeds or renal disorders exist in the urinary tract or elsewhere . Even though the effect of haematuria on hypertension is possible, it might be small and it could also be that higher blood pressure triggers more haematuria or that only a part of macroscopic haematuria episodes have their root in kidney disease or kidney bleeding.…”

Section: Discussionmentioning

confidence: 91%

Hypertension, haematuria and renal functioning in haemophilia – a cross‐sectional study in Europe

et al. 2015

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As in the general population, age and BMI were major risk factors for hypertension in people with haemophilia. Renal dysfunction was associated with hypertension, but the prevalence of renal dysfunction was not extensive and furthermore not significantly correlated with haematuria. The associations of other variables with hypertension require further studies to confirm causal relationships over time.

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Section: Discussionmentioning

confidence: 91%

Hypertension, haematuria and renal functioning in haemophilia – a cross‐sectional study in Europe

et al. 2015

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“…In a survey of the renal status in 26 people with hemophilia (age range, 17‐82 years), Beck and Evans reported a history of macroscopic hematuria in 69% of the patients. Later studies confirmed the high prevalence of hematuria among people with hemophilia . Although usually considered a benign condition, studies have found macroscopic hematuria associated with a reduction in renal function and an increased risk of hypertension, comorbid conditions that may complicate treatment in aging people with hemophilia.…”

Section: Introductionmentioning

confidence: 87%

Hematuria in aging men with hemophilia: Association with factor prophylaxis

Qvigstad

Tait

Moerloose

et al. 2020

Research and Practice in Thrombosis and Haemostasis

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Introduction Macroscopic hematuria is considered a significant risk factor for urologic disease, and it is highly prevalent in people with hemophilia. Aim To determine whether prophylactic factor replacement therapy is associated with reduced occurrence of macroscopic hematuria in people with hemophilia in a post hoc analysis using data from a cross‐sectional study conducted by the Age‐Related Developments and Comobordities in Hemophilia (ADVANCE) Working Group that included males with hemophilia ≥40 years of age. Methods Data from 16 contributing centers, in 13 European countries and Israel, were analyzed using logistic regression. Of 532 recruited individuals, this analysis included 370 patients with moderate or severe hemophilia who received on‐demand or prophylactic therapy. Results For patients with a history of macroscopic hematuria, we analyzed the association between prophylaxis and reoccurrence of macroscopic hematuria within the past 5 years (n = 235 patients). Frequent (≥3 times/wk) prophylaxis was negatively associated with a recent episode of macroscopic hematuria (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.18‐0.76). We also analyzed whether prophylaxis corresponded to a lower lifetime number of macroscopic hematuria episodes (n = 285 patients). Frequent prophylaxis for >15 years was associated with a lower number of episodes compared to on‐demand treatment (OR, 0.29; 95% CI, 0.16‐0.54), whereas nonsteroidal anti‐inflammatory drugs (NSAIDs) and severe hemophilia were associated with a higher number. There was no association of prophylaxis <3 times/wk with hematuria. Conclusion Frequent prophylaxis was negatively associated with the number of episodes of macroscopic hematuria in people with hemophilia. Prevalence of macroscopic hematuria was higher among individuals with severe hemophilia and those regularly using NSAIDs.

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“…In fact, cases of acute kidney injury secondary to tubular obstruction or cortical necrosis following renal bleeding treated with antifibrinolytic agents have been reported (25,26), and previous studies reported a reduction in kidney function in patients with haematuria (27). However, more recent data do not confirm these early findings, and now the role of kidney bleeding in renal disease pathogenesis remains to be clarified (28).…”

Section: Renal Involvement In Haemophilia: Focus On the Role Of Bloodmentioning

confidence: 98%

Renal diseases in haemophilic patients: pathogenesis and clinical management

Esposito

Rampino

Gregorini

et al. 2013

European J of Haematology

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Haemophilia A and B are genetic X-linked bleeding disorders, caused by mutations in genes encoding factors VIII and IX, respectively. Clinical manifestations of haemophilia are spontaneous haemorrhage or acute bleeding caused by minor trauma, resulting in severe functional consequences that can culminate in a debilitating arthropathy. Life expectancy and quality of life of patients with haemophilia have dramatically improved over the last years, mainly for new therapeutic options and the awareness to the risk of HCV and HIV infections. Different clinical problems arise from this important change in history of patients with haemophilia. In particular, ageing-related diseases, such as diabetes, hypertension and cancer, and chronic viral infections are emerging as new challenges in this patient population. Among the different types of chronic illnesses, renal diseases are of special interest as they involve some difficult management issues. In fact, decisions regarding adequate preventive strategies and viral infection treatment, the choice of the dialytic modality, placement of vascular access and prescription of dialytic treatments are particularly complicated, because only few data are available. In this review, we discuss the pathogenesis of renal damage in patients with haemophilia, especially in those with blood-transmitted viral infections, and the major issues about the management of renal diseases, including problems related to dialytic treatment and kidney transplantation, providing practical algorithms to guide the clinical decision-making process.

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Haematuria in patients with haemophilia and its influence on renal function and proteinuria

Cited by 14 publications

References 13 publications

Hypertension, haematuria and renal functioning in haemophilia – a cross‐sectional study in Europe

Hypertension, haematuria and renal functioning in haemophilia – a cross‐sectional study in Europe

Hematuria in aging men with hemophilia: Association with factor prophylaxis

Renal diseases in haemophilic patients: pathogenesis and clinical management

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