“…Flow disturbances created by the graft-vein anastomosis have been implicated in the pathogenesis of IH, but many attempts made to improve graft patency by modifying the geometry of the anastomosis were unsuccessful (Dilley et al, 1992;Dobrin et al, 1989;Ezzahiri et al, 1999;Fillinger et al, 1990;Hakim and Himmelfarb, 1998;Kanterman et al, 1995;Loth et al, 2003). In contrast, the role of the return needle turbulence during the hemodialysis process and its implications in the pathogenesis of VNH remains relatively unexplored (Zarate, 1998).…”