Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based study

Liu, Xu; Cf, Xu; Yu, Chao; Miao, Min; Ym, Li

doi:10.1136/gut.2009.186668

Cited by 29 publications

(26 citation statements)

References 5 publications

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“…Huang et al [30] observed that serum free hemoglobin may serve as a novel biomarker for acute ischemic stroke with a sensitivity of 70.2% and a specificity of is 85.3%. Moreover, serum hemoglobin levels have also been observed to be significantly elevated in extremely obese NAFLD patients by Trak-Smayra et al [16], and our recent cross-sectional study demonstrated that the serum hemoglobin level was significantly associated with prevalence of NAFLD [31]. In this prospective study, we showed that baseline serum hemoglobin level was positively associated with risk for development of NAFLD, and this association was independent of body mass index, type 2 diabetes, and other metabolic diseases.…”

Section: Discussionmentioning

confidence: 65%

Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease

et al. 2012

Journal of Hepatology

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Section: Discussionmentioning

confidence: 65%

Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease

et al. 2012

Journal of Hepatology

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“…In another population study, higher free serum hemoglobin has been associated with higher prevalence rates of NAFLD [21]. However, the source of free hemoglobin in serum was not identified.…”

Section: Discussionmentioning

confidence: 93%

“…Several promising serum biomarkers such as cytokeratin 18 need to be validated for non invasive diagnosis for NASH in large scale clinical trials [19]. A recent proteomic study has shown that free hemoglobin subunits α and β in serum are significantly increased in NASH patients as compared to those with steatosis [20], [21]The source of free serum hemoglobin in serum is unknown, but presumed to result from oxidative stress-induced hemolysis.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of Hemoglobin Expression by Oxidative Stress in Hepatocytes and Its Implication in Nonalcoholic Steatohepatitis

et al. 2011

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Recent studies revealed that hemoglobin is expressed in some non-erythrocytes and it suppresses oxidative stress when overexpressed. Oxidative stress plays a critical role in the pathogenesis of non-alcoholic steatohepatitis (NASH). This study was designed to investigate whether hemoglobin is expressed in hepatocytes and how it is related to oxidative stress in NASH patients. Analysis of microarray gene expression data revealed a significant increase in the expression of hemoglobin alpha (HBA1) and beta (HBB) in liver biopsies from NASH patients. Increased hemoglobin expression in NASH was validated by quantitative real time PCR. However, the expression of hematopoietic transcriptional factors and erythrocyte specific marker genes were not increased, indicating that increased hemoglobin expression in NASH was not from erythropoiesis, but could result from increased expression in hepatocytes. Immunofluorescence staining demonstrated positive HBA1 and HBB expression in the hepatocytes of NASH livers. Hemoglobin expression was also observed in human hepatocellular carcinoma HepG2 cell line. Furthermore, treatment with hydrogen peroxide, a known oxidative stress inducer, increased HBA1 and HBB expression in HepG2 and HEK293 cells. Importantly, hemoglobin overexpression suppressed oxidative stress in HepG2 cells. We concluded that hemoglobin is expressed by hepatocytes and oxidative stress upregulates its expression. Suppression of oxidative stress by hemoglobin could be a mechanism to protect hepatocytes from oxidative damage in NASH.

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“…Xu et al . has reported that serum hemoglobin concentration was significantly associated with NAFLD and the prevalence rate of NAFLD increased with progressively higher serum hemoglobin concentrations28. Yu et al .…”

Section: Discussionmentioning

confidence: 97%

Diagnostic accuracy and clinical utility of a new noninvasive index for hepatic steatosis in patients with hepatitis B virus infection

Zhang

Wang

Kai-fu

et al. 2016

Sci Rep

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The aim of the present study was to construct a cost-effective noninvasive diagnostic index for prediction of hepatic steatosis in patients with hepatitis B virus(HBV) infection. From January 2011 to January 2015, a total of 364 consecutive subjects who underwent liver biopsies were enrolled. The Receiver-operating characteristic(ROC) curves and Obuchowski measure were constructed to evaluate the diagnostic accuracy of the new index. The AUROCs of steatosis index of patients with HBV infection (SIHBV) in predicting of steatosis were 0.929 (95% confidence interval:0.889–0.970, P < 0.05) in the model group and 0.855 (0.794–0.917, P < 0.05) in the validation group respectively. Comparisons of AUROCs demonstrated that SIHBV was significantly superior to Korean Score, fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation product(LAP), and fatty liver disease (FLD) index for prediction of hepatic steatosis in model group and validation group(all P < 0.01). Especially for patients with hepatic steatosis percentage of 5.0–9.9% and 10.0–19.9%, SIHBV had a sensitivity of 63.6% and 79.2%, whereas it were 29.1% and 45.8% for Ultrasonography (all P < 0.05). In conclusion, as a cost-effective, simple, noninvasive, and readily available method, SIHBV may act as a massive screening tool before further examinations such as MRI, CT, transient elastography, or liver biopsy, especially for developing countries.

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Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based study

Cited by 29 publications

References 5 publications

Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease

Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease

Upregulation of Hemoglobin Expression by Oxidative Stress in Hepatocytes and Its Implication in Nonalcoholic Steatohepatitis

Diagnostic accuracy and clinical utility of a new noninvasive index for hepatic steatosis in patients with hepatitis B virus infection

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