Haemoglobin Nicosia. AN α‐CHAIN VARIANT AND ITS COMBINATION WITH β‐THALASSAEMIA

Hereditary Heinz-body Anaemia, Thrombocyttopenia, and Haemoglobinopathy (Hb Koln) in a Glasgow Family

“…Indeed, so far, this has been recognized only in the case of Haemoglobin Zurich (Frick et al, 1962), and Haemoglobin MChicago (Josephson, Weinstein, Yakulis, Singer, and Heller, 1962). The Lepore trait is occasionally associated with a mild haemolytic anaemia (Fessas, Stamatoyannopoulos, and Karaklis, 1962;Barkan, Stevenson, Pinker, Dance, and Shooter, 1964), and rarely somewhat more severe cases have been seen (Fdssas, personal comrmunication). Possibly some alleged instances of Hb Lepore with really severe haemolytic anaemia have the same form of haemoglobin abnormality present in our family.…”

A Swedish Haemoglobin Variant

“…These reports do not include information on the electrophoretic demonstration of a minor abnormal fraction. A hemoglobin moving like N has been observed recently in Greece, in which again no minor fraction could be demonstrated; this lib is still under study (Fessas, 1965).…”

Hemoglobin Hasharon (α247 his(CD5)β2): a hemoglobin found in low concentration

“…Detailed descriptions of the time course of specific activity can be obtained most easily by studying cells containing initially equal amounts (ha) of X (or cells for which f(a) has a very small a). Then we have in each and every cell: X(t) = hae-t0 [9] such that the average amount of abnormal hemoglobin in all cells is -h rT X = Ma f e-t/dt [10] where T is the life span of these cells given by The value of k could be predicted from equation 13 initial and final specific activity were known. The ratio of these two measurements depends directly on the initial concentration (a) of X in the cell, and on k:…”