Haemolytic complement activity, C3 and Factor B consumption in serum from chickens divergently selected for antibody responses to sheep red blood cells

Parmentier, H.K.; Baelmans, R.; Nieuwland, M.G.B.; Dorny, Pierre; Demey, F.

doi:10.1016/s0165-2427(02)00231-3

Cited by 24 publications

(19 citation statements)

References 31 publications

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“…Regarding humoral immunity, APV complement and IL8-like were especially lowered associated with the presence of antibiotics in the three species. APV complement is mainly related to the specific immunity, as well as to pathogen identification by heterophils and macrophages (Parmentier et al 2002). Lower values may be ineffective at avoiding the immediate heterophil defence against pathogens, thus allowing their acquisition and proliferation.…”

Section: R E T R a C T E Dmentioning

confidence: 99%

Cellular and humoral immunodepression in vultures feeding upon medicated livestock carrion

Lemus

Blanco

2009

Proc. R. Soc. B.

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Veterinary pharmaceuticals contained in dead livestock may be ingested by avian scavengers and negatively affect their health and consequently their population dynamics and conservation. We evaluated the potential role of antibiotics as immunodepressors using multiple parameters measuring the condition of the cellular and humoral immune system in griffon (Gyps fulvus), cinereous (Aegypius monachus) and Egyptian vultures (Neophron percnopterus). We confirmed the presence of circulating antimicrobial residues, especially quinolones, in nestlings of the three vulture species breeding in central Spain. Individuals ingesting antibiotics showed clearly depressed cellular and humoral immune systems compared with nestlings from the control areas, which did not ingest antibiotics. Within central Spain, we found that individuals with circulating antibiotics showed depressed cellular (especially CD4 C and CD8 C T-lymphocyte subsets) and humoral (especially acellular APV complement and IL8-like) immune systems compared with nestlings without circulating antibiotics. This suggests that ingestion of antibiotics together with food may depress the immune system of developing nestlings, temporarily reducing their resistance to opportunistic pathogens, which require experimental confirmation. Medicated livestock carrion should be considered inadequate food for vultures due to their detrimental consequences on health derived from the ingestion and potential effects of the veterinary drugs contained in them and for this reason rejected as a management tool in conservation programmes.

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Section: R E T R a C T E Dmentioning

confidence: 99%

Cellular and humoral immunodepression in vultures feeding upon medicated livestock carrion

Lemus

Blanco

2009

Proc. R. Soc. B.

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“…The general appearance of only a few haplotypes (B2, B15 and B21) may re£ect the importance of these haplotypes. The B2 and B21 haplotypes derived from White Leghorns Witter, 1992, 1994a,b) and B21-like haplotypes in Brown layers (Hepkema et al, 1991;Pinard and Hepkema, 1993;Parmentier et al, 2002) are generally associated with enhanced immune competence and enhanced disease resistance. The B15 of White Leghorns is often related to enhanced disease susceptibility Witter, 1992, 1993).…”

Section: Discussionmentioning

confidence: 99%

Serological Screening for MHC (B)-Polymorphism in Indigenous Chickens

Baelmans

Parmentier

Nieuwland

et al. 2005

Tropical Animal Health and Production

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As part of a series of studies to characterize innate and speci¢c immune responses of indigenous chicken lines, birds from Bolivia and India were screened serologically for MHC class IV (BG) polymorphism by direct haemagglutination using haplotype-speci¢c antisera (B2, B4, B12, B13, B14, B15, B19, B21). The sample consisted of 95 Bolivian indigenous chickens and 119 hens from the four most common North Indian`back-yard' chicken lines: Yellow Aseel (AP), Kadaknath (KN), frizzled typed (Ff^) and naked neck (NN). Of all chickens tested, the majority were haplotyped as B2, B15, B19 and B21. Of the Bolivian chickens, 89.5% could be haplotyped: 54.9% were homozygous (including 43.3% B15), and 34.6% were heterozygous (including 15.7% B15). B2-like haplotypes were not found among the Bolivian hens, and only 3.2% of these birds showed homozygous B21-like proteins. Of the Indian hens, MHC (BG)-like proteins could be detected in 60.0% of the AP birds, 6.7% of the KN birds; 40.0% of the Ff^birds; and 10.3% of the NN birds. In these lines, a total of 40.1% (AP), 6.7% (KN), 30.1% (Ff^) and 10.3% (NN) were homozygous for the B-haplotype. Only in the AP line (19.9%), and the Ff^line (9.9%) were heterozygous B-haplotypes types found. The B2 haplotype was found in all Indian chicken lines. Most Indian birds have completely unknown haplotypes, indicating a potentially interesting genetic pool. Subgrouping the Bolivian and Indian indigenous hens into monomorphic BG populations revealed individual di¡erences based on the B-types.

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“…Complement activity was not measured at day 2. Activity was measured using a hemolytic technique as described by Parmentier et al (2002) with an adapted light-scattering method. Serum was diluted and incubated with either sensitized sheep erythrocytes Statistical analysis Data were analyzed in SAS (Version 9.3, 2011, SAS Institute Inc., Cary, NC, USA) using cage as the experimental unit.…”

Section: Immunological Analysismentioning

confidence: 99%

Effects of feed access after hatch and inclusion of fish oil and medium chain fatty acids in a pre-starter diet on broiler chicken growth performance and humoral immunity

Lamot

Klein

Linde

et al. 2016

animal

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Delayed feed and water access is known to impair growth performance of day old broiler chickens. Although effects of feed access on growth performance and immune function of broilers have been examined before, effects of dietary composition and its potential interaction with feed access are hardly investigated. This experiment aimed to determine whether moment of first feed and water access after hatch and pre-starter composition (0 to 7 days) affect growth rate and humoral immune function in broiler chickens. Direct fed chickens received feed and water directly after placement in the grow-out facility, whilst delayed fed chickens only after 48 h. Direct and delayed fed chickens received a control pre-starter diet, or a diet containing medium chain fatty acids (MCFA) or fish oil. At 21 days, chickens were immunized by injection of sheep red blood cells. The mortality rate depended on an interaction between feed access and pre-starter composition ( P = 0.014). Chickens with direct feed access fed the control pre-starter diet had a higher risk for mortality than chickens with delayed feed access fed the control pre-starter diet (16.4% v. 4.2%) whereas the other treatment groups were in-between. BW gain and feed intake till 25 days in direct fed chickens were higher compared with delayed fed chickens, whilst gain to feed ratio was lower. Within the direct fed chickens, the control prestarter diet resulted in the highest BW at 28 days and the MCFA pre-starter diet the lowest (Δ = 2.4%), whereas this was opposite for delayed fed chickens (Δ = 3.0%; P = 0.033). Provision of MCFA resulted in a 4.6% higher BW gain and a higher gain to feed ratio compared with other pre-starter diets, but only during the period it was provided (2 to 7 days). Minor treatment effects were found for humoral immune response by measuring immunoglobulins, agglutination titers, interferon gamma (IFN-γ), and complement activity. Concluding, current inclusion levels of fish oil (5 g/kg) and MCFA (30 g/kg) in the pre-starter diet appear to have limited (carryover) effects on growth and development, as well as on humoral immune function.

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Haemolytic complement activity, C3 and Factor B consumption in serum from chickens divergently selected for antibody responses to sheep red blood cells

Cited by 24 publications

References 31 publications

Cellular and humoral immunodepression in vultures feeding upon medicated livestock carrion

Cellular and humoral immunodepression in vultures feeding upon medicated livestock carrion

Serological Screening for MHC (B)-Polymorphism in Indigenous Chickens

Effects of feed access after hatch and inclusion of fish oil and medium chain fatty acids in a pre-starter diet on broiler chicken growth performance and humoral immunity

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