HÆMOPHILIA Bm

Hougie, Cecil; Twomey, J.J.

doi:10.1016/s0140-6736(67)92683-9

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…(vi) Gla refers to glutamic acid residues normally -y-carboxylated, and ,B-hydroxyaspartate to the single modified aspartate residue. (vii) Bm: patients with a prolonged bovine prothrombin time (Hougie & Twomey, 1967).…”

Section: : 302-306mentioning

confidence: 99%

Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994

Giannelli¹,

Green²,

Sommer

et al. 1994

Nucl Acids Res

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The fifth edition of the haemophilia B database lists in easily accessible form all known factor IX mutations due to small changes (base substitutions and short additions and/or deletions of < 30bp) identified in haemophilia B patients. The 1,142 patient entries are ordered by the nucleotide number of their mutation. Where known, details are given on: factor IX activity, factor IX antigen in circulation, and origin of mutation. References to published mutations are given and the laboratories generating the data are indicated.

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Section: : 302-306mentioning

confidence: 99%

Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994

Giannelli¹,

Green²,

Sommer

et al. 1994

Nucl Acids Res

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“…Whole Blood Clotting Time. Whole blood clotting time (WBCT) assay was carried out as described by Hougie 19 with modification to determine the preliminary blood compatibility of the water-soluble chitooligosaccharides. Venous blood was collected from a human donor who was not on any medication.…”

Section: Depolymerization Of Chitosan/hd-chitosan With Nanomentioning

confidence: 99%

Characterization and Blood Coagulation Evaluation of the Water-Soluble Chitooligosaccharides Prepared by a Facile Fractionation Method

Lin

2003

Biomacromolecules

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Water-soluble chitooligosaccharides have been reported to have specific biological activities. In this study, the chitosan samples with different degree of acetylation were used separately to prepare chitooligosaccharide (COS) and highly deacetylated chitooligosaccharide (HDCOS) through the nitrous acid depolymerization. Rather than using the conventional fractionation schemes commonly employed, such as dialysis and ultrafiltration which require a large amount of deionized water as well as a fair long dwell time, an unique fractionation scheme is explored to recover and desalt these nitrous-acid depolymerized chitosan with different molecular weights. This fractionation scheme is based on the differential solubility variation of depolymerized products within the aqueous solutions that contain various ratios of methanol. It was noted that chitosan with different molecular weight can be successfully recovered and fractionated with methanol added sequentially up to a volume of four times of original depolmerized product. In addition, chemical characterization of the fractionated water-soluble COS and HDCOS by 1H NMR spectroscopy and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) indicated that the chitosan depolymerization reaction is greatly influenced by the degree of acetylation of the parental chitosan reactant. Moreover, the modified whole blood clotting time assay and the platelet coagulation test suggested that the 1:2 fractionated water-soluble COS and HDCOS obtained are much less procoagulant than their parental chitosan compound and can be of use in biomedical applications in which blood coagulation is not desired.

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“…(vi) GCa refers to glutamic acid residues normally -y-carboxylated, and ,B-hydroxyaspartate to the single modified aspartate residue. (vii) Bn-patients with a prolonged bovine prothrombin time (Hougie & Twomey, 1967). (viii) de novo-refers to a new mutation originating in mother, or maternal grandmother (MGM)-mother, but not grandmother carrying the mutation, and RFLP analysis indicating the mutant gene is inherited from the grandmother, or maternal grandfather (MGF)-mother but not grandparents carrying the mutation and RFLP analysis indicating the mutant gene is inherited from the grandfather.…”

Section: G-mentioning

confidence: 99%

Haemophilia B: database of point mutations and short additions and deletions—fourth edition, 1993

Giannelli¹,

Green²,

High

et al. 1993

Nucl Acids Res

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HÆMOPHILIA Bm

Cited by 3 publications

References 2 publications

Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994

Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994

Characterization and Blood Coagulation Evaluation of the Water-Soluble Chitooligosaccharides Prepared by a Facile Fractionation Method

Haemophilia B: database of point mutations and short additions and deletions—fourth edition, 1993

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